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We investigated if bone mineral density was related to testosterone deficiency and/or previous cancer treatment in men who were childhood cancer survivors. Men with untreated testosterone deficiency or previous treatment with cranial irradiation were at increased risk of impaired bone health. Prevention of osteoporosis should be considered in their follow-up. New publication in Osteoporosis Intern

https://www.lupop.lu.se/article/low-bone-mineral-density-associated-hypogonadism-and-cranial-irradiation-male-childhood-cancer - 2025-10-27

This study focuses on two central Scandinavian cities – Copenhagen and Stockholm – that are generally thought to be culturally close but have deviated with respect to cycling policies and infrastructure. Based on a survey including inhabitants of Copenhagen (n = 1110) and Stockholm (n = 1191), this study investigated whether cyclists in Copenhagen and Stockholm experience the transport systems in

https://www.lupop.lu.se/article/comparison-cycling-cultures-stockholm-and-copenhagen - 2025-10-27

To study the prevalence of chronic widespread pain (CWP) and chronic regional pain (CRP), and their association to quality of life, pain, physical function at a 20-year follow-up in a population based cohort with chronic knee pain at inclusion. New publication in BMC Musculoskeletal Disorders

https://www.lupop.lu.se/article/chronic-widespread-pain-and-its-associations-quality-life-and-function-20-year-follow-individuals - 2025-10-27

To estimate inappropriate opioid dispensing in patients with knee or hip osteoarthritis (OA) defined as (1) dispensing of opioids within the first year of diagnosis or (2) long-term opioid use. New publication in Osteoarthritis and Cartilage

https://www.lupop.lu.se/article/inappropriate-opioid-dispensing-patients-knee-and-hip-osteoarthritis-population-based-cohort-study - 2025-10-27

Directed acyclic graphs (DAGs), a prominent tool for expressing assumptions in epidemiologic research, are most useful when the hypothetical data generating structure is correctly encoded. Understanding a study’s data generating structure and translating that data structure into a DAG can be challenging, but these skills are often glossed over in training. New publication in Epidemiology

https://www.lupop.lu.se/article/graphical-catalog-threats-validity-linking-social-science-epidemiology - 2025-10-27

Sonographers have reported a high occurrence of musculoskeletal pain for more than 25 years. Assessments of occupational risk factors have previously been based on cross-sectional surveys. The aim of this longitudinal study was to determine which factors at baseline that were associated with neck/shoulder and elbow/hand pain at follow-up. New publication in BMC Musculoskeletal Disorders

https://www.lupop.lu.se/article/neck-and-upper-extremity-pain-sonographers-longitudinal-study - 2025-10-27

In the 1980s debate intensified over whether there was a protective effect of high-density lipoprotein cholesterol (HDL-C) or an adverse effect of triglycerides on coronary heart disease (CHD) risk. In a 1991 paper reprinted in the IJE we suggested that the high degree of correlation between the two, together with plausible levels of measurement error, made it unlikely that conventional epidemiolo

https://www.lupop.lu.se/article/correlation-without-cause-epidemiological-odyssey - 2025-10-27

Duplicate and salami publication are unethical, but are common practices with substantial consequences for science and society at large. Scientific journals are the ‘gatekeepers’ of the publication process. We investigated journal policies on duplicate and salami publication New publicationin International Journal of Epidemiology

https://www.lupop.lu.se/article/duplicate-and-salami-publication-prevalence-study-journal-policies - 2025-10-27

Directed acyclic graphs (DAGs) are popular tools for identifying appropriate adjustment strategies for epidemiological analysis. However, a lack of direction on how to build them is problematic. As a solution, we propose using a combination of evidence synthesis strategies and causal inference principles to integrate the DAG-building exercise within the review stages of research projects. We demon

https://www.lupop.lu.se/article/evidence-synthesis-constructing-directed-acyclic-graphs-esc-dags-novel-and-systematic-method - 2025-10-27

Exposures to perfluoroalkyl substances (PFAS) have shown positive associations with serum lipids in previous studies. While many studies on lipids investigated associations with perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), there are only a few studies regarding other PFAS, such as perfluorohexane sulfonic acid (PFHxS). The purpose of the current study is to investigate i

https://www.lupop.lu.se/article/associations-between-perfluoroalkyl-substances-and-serum-lipids-swedish-adult-population - 2025-10-27

Partial exchangeability is sufficient for the identification of some causal effects of interest. Here we review the use of common graphical tools and the sufficient component cause model in the context of partial exchangeability. We illustrate the utility of single world intervention graphs (SWIGs) in depicting partial exchangeability and provide an illustrative example of when partial exchangeabi

https://www.lupop.lu.se/article/graphical-description-partial-exchangeability - 2025-10-27

For a significant proportion of the older population, increasing age is associated with health problems and worsening health. Older family caregivers are largely responsible for care of next-of-kin living at home, which impacts their own physical and mental health both positively and negatively. However, evidence is insufficient regarding the health situation of older caregivers. The aim of this s

https://www.lupop.lu.se/article/analyzing-situation-older-family-caregivers-focus-health-related-quality-life-and-pain-cross - 2025-10-27

Analyses of causal mediation are often complicated by treatment-induced confounders of the mediator–outcome relationship. In the presence of such confounders, the natural direct and indirect effects of treatment on the outcome, into which the total effect can be additively decomposed, are not identified. An alternative but similar set of effects, known as randomized intervention analogues to the n

https://www.lupop.lu.se/article/effect-decomposition-presence-treatment-induced-confounding-regression-residuals-approach - 2025-10-27

Heparin is the preferred choice of anticoagulant in percutaneous coronary intervention (PCI) for acute myocardial infarction (MI). An established dosage of heparin has not yet been determined, but treatment may be optimized through monitoring of activated clotting time (ACT).. New publication in Europe PMC

https://www.lupop.lu.se/article/relationship-between-degree-heparin-anticoagulation-and-clinical-outcome-patients-receiving-potent - 2025-10-27

This issue of the Journal contains two articles focusing on how to draw causal conclusions using data from multiple studies that would generally be analyzed via meta-analysis. New publication in Epidemiology.

https://www.lupop.lu.se/article/importance-homogeneous-effect-modification-causal-interpretation-meta-analyses - 2025-10-27

In this population-based study, we compared the incidence of distal radius fracture in 2016 with that in the same region’s adult general population in 2001 using radiographs to identify fracture cases. We showed that the incidence decreased by 24% in 2016 compared with 2001 indicating an important development. New publication in Osteoporosis International

https://www.lupop.lu.se/article/incidence-distal-radius-fracture-general-population-southern-sweden-2016-compared-2001 - 2025-10-27

We recently suggested new statistical metrics for routine reporting in random-effects meta-analyses to convey evidence strength for scientifically meaningful effects under effect heterogeneity. First, given a chosen threshold of meaningful effect size, we suggested reporting the estimated proportion of true population effect sizes above this threshold. Second, we suggested reporting the proportion

https://www.lupop.lu.se/article/robust-metrics-and-sensitivity-analyses-meta-analyses-heterogeneous-effects - 2025-10-27

In this prospectively registered cohort study, we analyzed clinical, pathological, and survival outcomes for patients operated in the period 2008–2015 and compared the two strategies. New publication in World Journal of Surgery

https://www.lupop.lu.se/article/outcomes-simultaneous-resections-and-classical-strategy-synchronous-colorectal-liver-metastases - 2025-10-27

We take steps toward causally interpretable meta-analysis by describing methods for transporting causal inferences from a collection of randomized trials to a new target population, one trial at a time and pooling all trials. We discuss identifiability conditions for average treatment effects in the target population and provide identification results. We show that the assumptions that allow infer

https://www.lupop.lu.se/article/toward-causally-interpretable-meta-analysis-transporting-inferences-multiple-randomized-trials-new - 2025-10-27

Innehåll: DORIS redo för lansering i maj, befolkningsforskning en utmaning när data ska göras tillgängliga, SND lanserar nya webbsidor om datahantering för forskare, RDA-Sweden anordnar workshop om datahanteringsplaner Läs mer här.

https://www.lupop.lu.se/article/natverks-nytt-fran-snd - 2025-10-27