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As the highest level of cloud computing delivery model, Software-as-a-Service (SaaS) has gained considerable popularity in the industry as a new way of deploying IT solutions, due to its low cost and high elasticity. However, the new business model associated with SaaS highlights the importance for SaaS vendors to understand how to retain customers in a hyper-competitive market. In particular, inc
Today’s healthcare workers, specifically nurses, are experiencing technostress associated with the use of healthcare information technology (HIT). Technostress is often characterized by IS researchers as negative, or as being on the “dark side” of technology. However, a broader reading of the stress literature suggests that technostress may be both positive and negative, and can therefore have a “
As organizations continue to adapt and evolve to meet the challenges related to globalization and working with new collaboration technologies to bridge time and space, demands on employees’ time and attention continue to increase. Recognizing this problem and its implications, such as increased employee turnover, many companies are seeking ways to help their employees maintain a healthy balance be
Biochemical signaling is mediated by complexes between macromolecular receptors and their ligands, with the duration of the signal being directly related to the lifetime of the ligand-receptor complex. In the field of drug design, the recognition that drug efficacy in vivo depends on the lifetime of the drug-protein complex has spawned the concept of designing drugs with particular binding kinetic
Specific features of white matter microstructure can be investigated by using biophysical models to interpret relaxation-diffusion MRI brain data. Although more intricate models have the potential to reveal more details of the tissue, they also incur time-consuming parameter estimation that may converge to inaccurate solutions due to a prevalence of local minima in a degenerate fitting landscape.
In the past decades, transcriptomic studies have revolutionized cancer treatment and diagnosis. However, tumor sequencing strategies typically result in loss of spatial information, critical to understand cell interactions and their functional relevance. To address this, we investigate spatial gene expression in HER2-positive breast tumors using Spatial Transcriptomics technology. We show that exp
Studien syftade till att undersöka hur kvinnor från Irak och f.d. Jugoslavien, diagnostiserade med bröstcancer och boende i Sverige, upplever sin vardag under strålbehandling. En kvalitativ forskningsdesign användes som bestod av intervjuer med tio kvinnor, fem med ursprung i Irak och fem från f.d. Jugoslavien. Strävan för att överleva medförde att kvinnorna upplevde sin vardag under strålbehandliThis study aimed at exploring how women from Iraq and the former Yugoslavia, diagnosed with breast cancer and living in Sweden, experience their everyday life during radiation therapy. A qualitative research design was used comprising interviews with ten women, five originating from Iraq and five from the former Yugoslavia. Striving to survive, the women experienced their everyday life during radi
Bokkapitel i Handbook of Nuclear Medicine and Molecular Imaging for Physicistsutoradiography is defined as technologies and methods used to produce a two-dimensional image of the distribution of activity in, or on, a thin and solid sample that is in close proximity to the detector. The images are usually formed by charged particles (α or β±), and image characteristics are determined both by the detector and the properties of the particles detected. This method is not widely
The competition between a spherical macroion and a polyelectrolyte in complexation with an oppositely charged flexible polyelectrolyte has been studied by means of Monte Carlo simulations. A simple model system with focus on the electrostatic interactions has been used to investigate under what conditions the macroion in a polyelectrolyte-macroion complex (excess of polyelectrolyte charges) is exc
The structural properties of the salivary proteins, acidic proline rich PRP-1 and statherin, adsorbed onto negatively charged surfaces have been studied by Monte Carlo simulations and ellipsometry. It is shown that both proteins adsorb to negatively charged surfaces, although their net charges are negative. Experimentally, an initial fast mass-controlled film build-up was detected for both protein
The structural properties of the salivary protein statherin upon adsorption have been examined using a coarse-grained model and Monte Carlo simulation. A simple model system with focus on electrostatic interactions and short-ranged attractions among the uncharged amino acids has been used. To mimic hydrophobically modified surfaces, an extra short-ranged interaction was implemented between the ami
Historical data are valuable resources for providing insights into general patterns in the past. However, these data often inform us at the macro-level of analysis but not about the role of individuals’ behaviours in the emergence of long-term patterns. Therefore, it is difficult to infer ‘how’ and ‘why’ certain patterns emerged in the past. Historians use various methods to draw hypotheses about
Fire regimes across the world are expected to be altered by continuing variations in socio-economic conditions and climate. Current global fire-vegetation models are able to represent the present-day fire activity, but it is unclear how well they can simulate past or future scenarios. Here we use sedimentary charcoal-based biomass burning reconstructions to evaluate fire probability and total carb
BackgroundA concussion is a common injury in many sports, including para sport. Aside from a more comprehensive need for concussion education, clinicians face difficulties applying concussion assessment and management guidelines to para athletes.1 At present, there is a lack of para-sport concussion research, and prior International Concussion in Sport (CIS) consensus papers have not addressed thi
