Sökresultat

Droughts are often long-lasting phenomena, without a distinct start or end and with impacts cascading across sectors and systems, creating long-term legacies. Nevertheless, our current perceptions and management of droughts and their impacts are often event-based, which can limit the effective assessment of drought risks and reduction of drought impacts. Here, we advocate for changing this perspec

Background Fidanacogene elaparvovec, an adeno-associated virus (AAV) gene-therapy vector for hemophilia B containing a high-activity human factor IX variant (FIX-R338L/FIX-Padua), was associated with sustained factor IX activity in a phase 1-2a study. Methods We conducted a phase 3 open-label study of fidanacogene elaparvovec at a dose of 5×1011 vector genome copies per kilogram of body weight. Me

Slight modifications to the manufacturer’s protocol (Qiagen #12966-10, now discontinued and replaced with #12988-10) enabled the successful extraction of high-quality DNA and RNA from permafrost peat samples. Integrating the DNA and RNA purification steps immediately after the extraction process helped streamline the workflow, resulting in consistent quality nucleic acids suitable for downstream s

Mid-ocean ridges are unique, tectonically active geographical units on Earth that profoundly control the ocean environment and dynamics at the global scale. However, high-resolution topographic data from mid-ocean ridges are rarely available due to the difficulty in detecting ocean floors, which further limits ocean research at the global scale. Here, we divide the global mid-ocean ridge system in

Blood biomarkers have emerged as accessible, cost-effective, and highly promising tools for advancing the diagnostics of Alzheimer's disease. However, transitioning from cerebrospinal fluid biomarkers to blood biomarkers—eg, to verify amyloid β pathology—requires careful consideration. This Series paper highlights the main challenges in the implementation of blood biomarkers for Alzheimer's diseas

Clinical management and therapeutics development for Alzheimer's disease (AD) have entered a new era, with recent approvals of monoclonal antibody therapies targeting the underlying pathophysiology of the disease and modifying its trajectory. Imaging and fluid biomarkers are becoming increasingly important in the clinical development of AD therapeutics. This review focuses on the evidence of fluid

Objective: The National Penile Cancer Register (NPECR) in Sweden was initiated in year 2000 and currently contains more than 3,900 men diagnosed with penile cancer. The aim of this study was to evaluate data quality in the NPECR in terms of completeness, timeliness, comparability, and validity. Material and methods: Completeness was assessed by cross-linkage to the Swedish Cancer Register. Timelin

Soil microorganisms are pivotal in the global carbon cycle, but the viruses that affect them and their impact on ecosystems are less understood. In this study, we explored the diversity, dynamics, and ecology of soil viruses through 379 metagenomes collected annually from 2010 to 2017. These samples spanned the seasonally thawed active layer of a permafrost thaw gradient, which included palsa, bog

The IPCC holds the gold standard for climate change scientific knowledge and authority at the science–policy interface. Here we reflect on our experience of the IPCC Sixth Assessment Report and discuss how diversity in authorship and inclusion of different disciplinary backgrounds can be improved.

The Drawing of Our Lives in Berlin 2007-2022 (2022) and Narrating our Lines (2010) for the group exhibition 'The infinite body' at Ramat Gan Museum of Israeli Art, plan b are showing an installation combining two existing works - a large scale drawing and a video work.

The advances in highly automated and autonomous transportation systems over the last decade have generated great interest in topics in the safe navigation of land vehicles. With distributed control strategies employed in the majority of applications of autonomous vehicles, such as traffic and formation control, the much-required resilience takes the form of fault-tolerance with respect to informat

South Korea is attempting to deal with the now-universal issue of disinformation. So why did its draft bill attract such fierce criticism?

The left lateralization of language has been attributed to hemispheric specialization for processing rapidly changing information. While interhemispheric differences in auditory cortex organization support this view, the macrostructure of the entire cerebral cortex has not been thoroughly examined from this perspective. This study investigated hemispheric asymmetries in cortical surface area and t

This study aimed at evaluating the effects of non-fermented and fermented pseudocereal flours, quinoa and canihua, on iron and zinc bioavailability in Wistar rats. Two diets prepared with 92% fermented quinoa or 79.5% fermented canihua were compared with diets prepared with the same amount of non-fermented pseudocereals. Other two quinoa diets were prepared with 60% non-fermented or fermented quin

Introduction: Grey pea is a largely overlooked legume in the Nordic countries, and its potential uses in various food products remain unexplored. It is a nutrient-rich crop with low environmental impact, making it an attractive option for sustainable and nutritious plant-based alternatives. Objectives: To investigate the impact of dehulling, germination, and fermentation on the bioactive (poly

The entanglement of domestic and geopolitical dynamics with the evolution of the aid strategies of the Gulf States is particularly evident in the Horn of Africa (HOA), where the regional competition for exercising influence has affected the modalities of humanitarian and development interventions. A comparison of the foreign aid given by Qatar and the United Arab Emirates (UAE) to Sudan in the con