Low-dose tamoxifen treatment reduces collagen organisation indicative of tissue stiffness in the normal breast : results from the KARISMA randomised controlled trial
Background: Tissue stiffness, dictated by organisation of interstitial fibrillar collagens, increases breast cancer risk and contributes to cancer progression. Tamoxifen is a standard treatment for receptor-positive breast cancer and is also aproved for primary prevention. We investigated the effect of tamoxifen and its main metabolites on the breast tissue collagen organisation as a proxy for sti