Global production rates of metals vary from iron at 1.4 billion ton per year to platinum with 200 ton per year. Resource scarcity starts to manifest itself in rising prices and supply limitations, and metal substitution has been a major argument among economists when putting considerations of resource scarcity aside. Here we investigate the potential limits to metal substitution. Present consumpti

The total resources form copper, zinc and lead was estimated from a reworking of the literature. The data was used as input to the integrated systems dynamics model BRONZE, and used to estimate the global supply of these metals and the by-products antimony, indium, germanium, tellurium, cadmium, bismuth and selenium. The runs show that copper, zinc and lead go through peak production around 2050 a

The global supply of cobalt was simulated by combining 3 different system dynamics models; BRONZE, PGM and STEEL. The present use of cobalt shows a low degree of recycling and systemic losses are significant. The reserves of cobalt are not very large (20-25 million ton extractable) as compared to metals like copper, zinc or iron, and after 2170 cobalt will have run out under a business-as-usual sc

The complement system is an ancient part of the innate immune system important for both tissue homeostasis and host defense. However, bacteria like Staphylococcus aureus (SA) possess elaborative mechanisms for evading both the complement system and other parts of the immune system. One of these evasive mechanisms-important in causing chronic and therapy resistant infections-is the intracellular pe

Innovations in urban governance such as Urban Living Labs (ULL) are expected to accelerate the transition towards more sustainable and climate-resilient cities. This article reviews different ULL across Europe and explores the role and potential capacity of municipalities in the development of and/or facilitation of ULL as a form of experimental governance. It focuses on the role of the public sec

Ribonucleotide reductases (RNRs) are key enzymes in DNA metabolism, with allosteric mechanisms controlling substrate specificity and overall activity. In RNRs, the activity master- switch, the ATP-cone, has been found exclusively in the catalytic subunit. In two class I RNR subclasses whose catalytic subunit lacks the ATP-cone, we discovered ATP-cones in the radical- generating subunit. The ATP-co

J Thromb Haemostas 2009;7(Suppl2):abstract 428. DOI: 10.1111/j.1538-7836.2009.03473_2.x

Silicon (Si) is the second most abundant element in the Earth’s crust and is an important nutrient in the ocean. The global Si cycle plays a critical role in regulating primary productivity and carbon cycling on the continents and in the oceans. Development of the analytical tools used to study the sources, sinks, and fluxes of the global Si cycle (e.g., elemental and stable isotope ratio data for

J Thromb Haemostas 2009;7(Suppl2) abstract 695. DOI: 10.1111/j.1538-7836.2009.03473_2.x

Breast tumors of the basal-like, hormone receptor-negative subtype remain an unmet clinical challenge, as there is high rate of recurrence and poor survival in patients following treatment. Coevolution of the malignant mammary epithelium and its underlying stroma instigates cancer-associated fibroblasts (CAFs) to support most, if not all, hallmarks of cancer progression. Here we delineate a previo

Measurements of ZZ production in the +-′+′- channel in proton-proton collisions at 13 TeV center-of-mass energy at the Large Hadron Collider are presented. The data correspond to 36.1 fb-1 of collisions collected by the ATLAS experiment in 2015 and 2016. Here and ′ stand for electrons or muons. Integrated and differential ZZ→+-′+′- cross sections with Z→+- candidate masses in the range of 66 GeV t

When using fluorescence microscope techniques to study cells, it is essential that the cell structure and contents are preserved after preparation of the samples, and that the preparation method employed does not create artefacts that can be perceived as cellular structure/components. γ-Tubulin forms filaments that in some cases are immunostained with an anti-γ-tubulin antibody, but this immunosta

Purpose: The purpose of this paper is to explore how the notion of “relevance” is produced, distributed and consumed in the field of management research by applying a critical discourse analysis (CDA) as a theoretical lens. A CDA perspective offers a way to scrutinize the power relations that emerge with journal rankings and how these influence how the relevance discourse develops. Design/methodol

We investigated the pragmatic effects of gesture-speech lag by asking participants to reconstruct formations of geometric shapes based on instructional films in four conditions: sync, video or audio lag (±1,500 ms), audio only. All three video groups rated the task as less difficult compared to the audio-only group and performed better. The scores were slightly lower when sound preceded gestures (

This paper studies the role of imported inputs in explaining firms’ export behaviour. Unlike most of the existing literature we are also able to control for the participation of domestic firms to multinational networks. This allows us to test to what extent the recurrent evidence that importing foster exporting activity is instead a figment of the fact that importers are also part of multinational

Bacterial strains were isolated from the sediments of the Baltic Sea using ferulic acid, guaiacol or a lignin-rich softwood waste stream as substrate. In total nine isolates were obtained, five on ferulic acid, two on guaiacol and two on a lignin-rich softwood stream as a carbon source. Three of the isolates were found to be Pseudomonas sp. based on 16S rRNA sequencing. Among them, isolate 9.1, wh

Mantle cell lymphoma (MCL) is associated with poor prognosis due to an aggressive clinical course. Being a raredisease, there are few randomized trials in MCL and there is no defined golden standard in primary treatment.This works aimed to (I) investigate outcome in relation to primary treatment in MCL based on population-basedregistry data, (II) to evaluate tolerability and efficacy of lenalidomiMantle cell lymphoma (MCL) is associated with poor prognosis due to an aggressive clinical course. Being a rare disease, there are few randomized trials in MCL and there is no defined golden standard in primary treatment. This works aimed to (I) investigate outcome in relation to primary treatment in MCL based on population-based registry data, (II) to evaluate tolerability and efficacy of lenalid