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Cartilage Oligomeric Matrix Protein initiates cancer stem cells through activation of Jagged1-Notch3 signaling

Cancer stem cell populations are important for the initiation, progression and metastasis of tumors. The mechanisms governing cancer stem cell control are only partially understood, but activation of the Notch3 pathway plays a crucial role in the maintenance of breast cancer stem cells. Expression of Cartilage Oligomeric Matrix Protein (COMP) in breast cancer cells is correlated with poor survival

Association between semen parameters and chance of fatherhood - a long-term follow-up study

Background: Evaluation of male fertility includes standard semen analysis; however, there is uncertainty about the value of sperm parameters in predicting fertility. Objective: To evaluate the association between semen parameters and fatherhood during a long-time period. Materials and methods: Semen parameters (total sperm count, concentration, motility, and morphology) and sperm DNA fragmentation

The impact of lecture recordings on he student approaches to learning

The impact of lecture recordings on HE student approaches to learning Note-taking as a study-skill amongst students in Higher Education (HE) is acknowledged as a fundamental component of academic success. Intrinsic factors such as cognitive capacity, motivation and epistemological beliefs effect note-taking quantity and quality (e.g. Kiewra, 1985). However, this study looks at the extrinsic influe

High risk of permanent stoma after anastomotic leakage in anterior resection for rectal cancer

Aim: This study investigates how often bowel continuity was restored after anastomotic leakage in anterior resection for rectal cancer and assesses the clinical factors associated with permanent stoma. Method: The Swedish Colorectal Cancer Registry was used to identify cases of anastomotic leakage registered in southern Sweden between January 2001 and December 2011. Patient characteristics, surgic

BENCHOP–SLV : the BENCHmarking project in Option Pricing–Stochastic and Local Volatility problems

In the recent project BENCHOP–the BENCHmarking project in Option Pricing we found that Stochastic and Local Volatility problems were particularly challenging. Here we continue the effort by introducing a set of benchmark problems for this type of problems. Eight different methods targeted for the Stochastic Differential Equation (SDE) formulation and the Partial Differential Equation (PDE) formula