Syftet med avhandlingen var att undersöka och utvärdera bindningen av molekyler mot ett målprotein som är involverad i tillväxten av cancerceller. Undersökning genomfördes på Red Glead Discovery med WAC (weak affinity chromotography) som är en kromatografisk separationsmetod, där molekyler med olika vikt pumpas genom olika kolonner och retentionstiden för molekylerna i kolonnen detekteras. MolekylThe drug discovery and development process has changed dramatically during the last decades and the growth of more efficient techniques as high throughput screening combined with combinatorial synthesis using amino acids and carboxylic acids on solid support makes it possible to investigate the affinity of molecules towards a biological target. Fragment based drug discovery (FBDD) has been impleme

The aim of this master thesis is to examine how institutional rules and demands, present in cultural politics, affects the work with digitalisation in local museums. According to narrative trends in Sweden’s national cultural politics, digitalisation has the potential to encourage and increase democracy by enabling participation and wider access. Therefore, digitisation practices in cultural insti

This thesis aims to deconstruct the manner in which cultural differences are perceived and dealt with in international and multicultural school in Sweden by combining postcolonial and poststructuralist theories. Applying Bhabha’s theoretical turn from cultural diversity to cultural differences, ethnographic methods were used to examine parents’ and staff member’s relationship with these difference

The goal of this thesis is to construct p-harmonic functions on the Lie groups U(n), SU(n), U(p,q) and SU(p,q) equipped with the semi-Riemannian metric g(Z,W) = Re trace ( Z W^t ). To do this we present a method which relies on the notion of eigenfunctions. We define these functions and find examples of them defined on the relevant groups. To our knowledge, these eigenfunctions have not been p

The Defunctionalization of carbonyl functionality into methylene by metal-catalyzed hydrosilylation is very important in organic synthesis. But very less work is done in literature because of the need for a large amount of energy for C-O bond dissociation. Metal-catalyzed defunctionalization of carbonyl compounds in the presence of silanes as a mild reducing agent is studied because of its presenc

Befolkningen i Sverige står inför en demografisk utveckling och en allt större andel av Sveriges befolkning kommer vara äldre. År 2018 estimerades att andelen personer äldre än 80 år kommer öka med upp till hela 50 procent i Sverige under de närmaste tio åren Det leder i sin tur till en större påfrestning på landets vård och omsorg och det kommer behövas fler äldreboenden för att möta den ökande eThe Swedish population is facing a demographic development that will result in a larger proportion of the population being older than it is today. This will lead to a greater strain on the country’s health- and elderly care systems. In 2018, it was estimated that the proportion of people older than 80 years will increase by as much as 50 % in Sweden over the next ten years. With an increased numbe

Syftet med den aktuella studien var att, med kvalitativ och explorativ ansats, undersöka förutsättningarna för föräldrar till barn med autismspektrumtillstånd (AST) att skapa trygg anknytning för sina barn, utifrån en förståelse för deras tankar och känslor om sin relation med sitt barn, och sitt föräldraskap – så kallade omvårdnadsrepresentationer. Vidare syftade studien till att undersöka huruvi

Förpackningar är viktigare än vad man kan tro! De skyddar den värdefulla produkten från oönskade bakterier som kan göra att den blir dålig. För att drycken ska hålla längre så måste förpackningen behandlas för att ta bort allt som kanske kan skada personen som dricker innehållet. Man ser också till att bakterier utanför förpackningen inte kan ta sig in. Detta innebär att förpackningen är aseptisk.Sealing of the transverse seal (TS) represents a fundamental step in the assembling of aseptic packages. To prevent the package from being penetrated by gases and pathogens the TS must be tightly sealed. An understanding of the conditions that influence the flow and deformation of polymers is instrumental to designing sealing systems that are reliable and effective. This thesis was focused on cons

This study is an exploratory qualitative case study that seeks to capture nuanced and personal perspectives on the experiences of the Tunisian democratization process. The aim of this study is to examine what the expectations of the regime change was and how these expectations relate to the perceived reality. In doing so, it utilizes a theoretical framework based on elements from the works of Seym

As Europe witnesses a rise in support of the far-right, more attention is being paid to why nationalistic sentiment is gaining popularity, particularly amongst rural populations. However, less known is how nationalism interacts with pressing ecological issues, even less so with agricultural matters. Given that a large proportion of farmers in the UK are said to have supported Brexit, it is importa

It is generally agreed upon that social trust is strongly associated with income inequality. However, this conclusion is mainly drawn from cross-country studies, which most likely suffer from endogeneity issues due to unobserved cultural, social and political variables affecting both trust and inequality. In this paper we collect trust data from six different surveys and make them comparable throu

Sustainability issues within the fashion market is frequently debated. Especially, whether fast fashion can be considered as sustainable. This bachelor thesis draws on the discussion about fast fashion and sustainability, and how different discourses is being reproduced within different media outlets. By comparing journalistic articles about fast fashion and sustainability from the news media outl

Here a lung-on-a-chip device was developed and fabricated using 3D-printing of molds. The lung-on-a-chip device was used as a lung injury model by overstretching of murine lung epithelial cells (MLE-12) monolayers, resembling the injury during mechanical ventilation. The cells were exposed to 25% strain, representing pathological conditions seen in ventilator induced lung injury of patients with

A key process in a manufacturing system with assembly lines, is the assembly line feeding, i.e. how material needed in the assembly process is supplied at the assembly lines. This has been formulized as the assembly line feeding problem. The purpose of the thesis project is to give insights into the impact the choice of line feeding method has on production downtime. Moreover, the impact the produ

Health achievements are central to human happiness and well-being. Yet, disagreement immerse on how to best create them. Health policy analyses have been seen as one way to gain insights and to identify factors that generate health outcomes. The aim of this study is to contribute to this task through a comparative case study in Rwanda and South Africa. Indeed, both countries diverge in terms of hi

This thesis concerns Flettner rotors, a wind propulsion technology for commercial shipping which has recently gained momentum due to its ability to reduce fuel consumption, and consequently CO2 emissions, in a polluting sector of industry. Flettner rotors are able to reduce average fuel consumption by up to 20% and can be operated on a wide variety of ship types and sizes through both retrofit and

The success of energy transitions in India depends on the feasibility of rapid expansion of solar power. How fast solar power can be expanded depends on its profitability, which has not been systematically analysed in prior literature. This paper answers three questions – (i) What is the profitability of utility scale solar power in six selected states in India (Karnataka, Tamil Nadu, Maharashtra,

Costa Rica is one of Latin America’s pioneers in terms of steady economic growth, environmental protection, and educational spending. Yet behind this general perception, the country faces structural problems, like high inequality levels and sky-rocketing youth unemployment, indicating rather exclusive development pattern. In order to tackle these challenges, the government places high hopes in the

Denna uppsats behandlar hur vårt språk påverkar vår förståelse av verkligheten, och hur detta i sin tur kan tänkas påverka människor med funktionsskillnader. Analysen utgår ifrån en korpusundersökning av olika benämningar för människor med funktionsskillnader, detta för att se i vilka kontexter de olika orden används. Orden som analyseras är: handikappad, funktionsnedsättning, funktionshinder och

Studiens syfte är att undersöka fyra trumlärares syn på hur de undervisar sina elever vid det Estetiska programmet i att öva på sitt instrument och hur de ser på elevernas motivation. Studien syftar också till att undersöka hur trumlärarna ser på att undervisa sina elever i att utveckla det specifika övningsområdet spelteknik på trumset. Utifrån litteratur och tidigare forskning kring temat övningThe purpose of this study is to examine four drum teachers' views on how they teach their students at the aesthetic program how to practice as well as how they look at their students' motivation. The study also specifically aims to examine how the drum teachers approach teaching their students how to develop their playing technique on the drum kit. Based on the literature and previous rese