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CONTEXT: When clinically stable, patients with A-β+ Ketosis-Prone Diabetes (KPD) manifest unique markers of amino acid metabolism. Biomarkers differentiating KPD from type 1 (T1D) and type 2 diabetes (T2D) during hyperglycemic crises would accelerate diagnosis and management.OBJECTIVE: Compare serum metabolomics of KPD, T1D and T2D patients during hyperglycemic crises, and utilize Classification a

Background: Hydrophilic polymer embolization (HPE) is a scarcely reported complication associated with endovascular procedures where the hydrophilic coating dislodges and disseminates to more distal vascular beds, leading to ischemic complications. The aim of this study is to assess the clinical outcomes associated with HPE in the literature and try to quantify it in a scoping manner. Methods: All

BackgroundIn the splice variant factor (F)V-Short, 702 residues are deleted from the B domain, resulting in exposure of an acid region (AR2; 1493-1537) that binds TFPIα. FV-Short and protein S serve as synergistic TFPIα cofactors in inhibition of FXa. In the preAR2 region, a hydrophobic patch PLVIVGL (1481-1487) is crucial for synergistic TFPIα-cofactor activity and assembly of FV-Short, TFPIα, anBackgroundIn the splice variant factor (F)V-Short, 702 residues are deleted from the B domain, resulting in exposure of an acid region (AR2; 1493-1537) that binds TFPIα. FV-Short and protein S serve as synergistic TFPIα cofactors in inhibition of FXa. In the preAR2 region, a hydrophobic patch PLVIVGL (1481-1487) is crucial for synergistic TFPIα-cofactor activity and assembly of FV-Short, TFPIα, an

The IFMIF-DONES Facility is a unique first-class scientific infrastructure whose construction is foreseen in Granada, Spain, in the coming years. Strong integration efforts are being made at the current project phase aiming at harmonizing the ongoing design of the different and complex Systems of the facility. The consolidation of the Diagnostics and Instrumentation, transversal across many of the

The European Spallation Source, currently under construction in Lund, Sweden, is a multidisciplinary international laboratory. Once completed to full specifications, it will operate the world’s most powerful pulsed neutron source. Supported by a 3 million Euro Research and Innovation Action within the EU Horizon 2020 program, a design study (HighNESS) has been completed to develop a second neutron

Recent experiments at the Brazilian Synchrotron Ligth Source (LNLS) Ultra Violet and X-Ray beamlines are pushing on the Synchrotron Radiation (SR) beam position stability requirements. In the direction of having photon Beam Position Monitor integrated to the orbit closed loop control system, we developed a staggered blades XR BPM and a four-channel current measurement electronics. The BPM mechanic

At the Istituto Nazionale di Fisica Nucleare – Laboratori Nazionali del Sud (INFN-LNS) the commissioning of the high intensity Proton Source for the European Spallation Source (PS-ESS) started some weeks ago. Beam stability at high current intensity is one of the most important parameter for the first steps of the ongoing commissioning. Commissioning plan and preliminary characterization are also

The surfaces of poly(l-lactic acid) (PLLA) and poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) were modified by oxygen and nitrogen plasma treatments. The physical and chemical surface characteristics were evaluated by contact angle tests, scanning electron microscopy (SEM), atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS). The plasma treatments caused an increase in both

We present the results of the commissioning of the first Elliptically Polarizing Undulator (EPU) to be installed at the 1.37 GeV electron storage ring of the Brazilian Synchrotron Light Source (LNLS). The undulator is designed to provide UV and soft X-ray photons from 100 eV up to 1 keV with full polarization control. It uses the APPLE II design and allows for both parallel and anti-parallel longi

We present the results of the commissioning of a 28-pole 2 T Hybrid Wiggler at the electron storage ring of the Brazilian Synchrotron Light National Laboratory (LNLS). The wiggler will be used mainly for protein crystallography and was optimized for the production of 12 keV photons. We describe the effects of the insertion device on the storage ring lattice, such as the correction of the linear tu

We present the electrical and mechanical design of a button beam position monitor (BPM) recently developed and installed in the UVX electron storage ring at the Brazilian Synchrotron Light Laboratory (LNLS). The first characterization results will also be presented. This development started when we observed strong correlation between false stripline BPM readings and the external temperature of thi

Among several methods used to obtain ultra-high vacuum (UHV) for particles accelerators chambers, it stands out the internal coating with metallic films capable of absorbing gases, called NEG (non-evaporable getter). Usually these materials are constituted by elements of great chemical reactivity and solubility (such as Ti, Zr, and V), at room temperature for oxygen and other gases typically found

The substrate preparation for CVD diamond growth is of basic importance due to several reasons. A new molybdenum substrate preparation method, the aluminum oxide abrasion jetting, is introduced and compared with the traditional ones. Raman Scattering Spectroscopy (RSS) and Scanning Electron Microscopy (SEM) characterize CVD diamond films. CVD diamond films of good quality and uniformity were obtai

Following the upgrade of the LNLS injector system with the addition of a 500 MeV booster synchrotron, the storage ring in vacuum ferrite injection kicker magnets started to show overheating due the interaction with high frequency electromagnetic fields induced by the electron beam in large currents. In this paper, we describe the design of a new ceramic chamber for the kickers, which minimize this

We present the design of the vacuum chamber for the LNLS 2T Hybrid Wiggler. The chamber is a 3m long, 1.2mm thick 316L SS tube, which was mechanically pressed into an elliptical shape from an originally round tube. In order to provide the necessary mechanical tolerances, the rather flexible tube is welded to lateral supports that run the complete length of the chamber. Special care has been given

Proton-γ coincidences from (d,p) reactions between a Ni66 beam and a deuterated polyethylene target have been analyzed with the inverse-Oslo method to find the nuclear level density (NLD) and γ-ray strength function (γSF) of Ni67. The Ni66(n,γ) capture cross section has been calculated using the Hauser-Feshbach model in TALYS using the measured NLD and γSF as constraints. The results confirm that