A radical view of haemoglobin - protein engineering and characterisation
In recent years shortages of donated blood have become a growing problem for health care systems world-wide. Blood substitutes based on human haemoglobin (Hb) could potentially ameliorate this situation. However, clinical trials have indicated problems due to e.g. oxidative stress. This thesis describes ways to detoxify the Hb by modulating radical reactions or by reducing radical toxicity using a