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Purpose: Proteases have been implicated in cancer progression and invasiveness. We have investigated the activities, as opposed to simple protein levels, of selected aminopeptidases in urine specimens to serve as potential novel biomarkers for urothelial cancer. Experimental design: The unique urinary proteomes of males and females were profiled to establish the presence of a gender-independent se
Background Biomarkers based on detecting prostate cancer (PCa)-specific transcripts in blood are associated with inferior outcomes, but their validation in a clinical context is lacking. Objective To determine whether detecting enhanced transcripts for PCa in whole blood using an analytically valid assay has prognostic significance relative to circulating tumor cell (CTC) enumeration. Design, sett
Denna avhandling undersöker den svenska befolkningens attityder i förhållande till en ekosocial agenda utifrån ett hållbart välfärdsperspektiv. Forskare har länge angripit frågor om miljö och välfärd som två separata fält. De aktuella miljö- och klimatförändringarna visar dock att dessa två fält måste förstås i samklang med varandra om vi ska kunna ställa om till ett klimatneutralt samhälle där håThis thesis explores Swedish residents’ attitudes related to an eco-social agenda from a sustainable welfare perspective. It investigates public support for general policy goals related to an eco-social agenda as well as for specific eco-social policies. The thesis also analyses the significance of the individuals’ socioeconomic characteristics, their values, and the context they are situated in r
Objectives: To assess the applicability of the Prostate Cancer Prevention Trial High Grade (Gleason grade ≥ 7) Risk Calculator (PCPTHG) in ten international cohorts, representing a range of populations. Methods: A total of 25,512 biopsies from 10 cohorts (6 European, 1 UK and 3 US) were included; 4 implemented 6-core biopsies, and the remaining had 10 or higher schemes; 8 were screening cohorts, a
Background: Previous studies evaluating the association between leisure activities and cognitive function produced conflicting results. Different types of leisure activities may have different effects on cognition, and very few studies have explored their bidirectional associations. Our study aimed to explore whether intellectual and social activities had bidirectional associations with cognitive
This article updates advances in prostate cancer screening based on prostate-specific antigen, its derivatives, and human kallikrein markers. Many men are diagnosed with indolent disease not requiring treatment. Although there is evidence of a survival benefit from screening, the numbers needed to screen and treat remain high. There is risk of exposing men to the side effects of treatment for nont
Heroes and villains, idealists and mercenaries, freedom fighters and religiousfanatics. Foreign fighters tend to defy easy classification. Good andbad images of the foreign combatant epitomize different conceptions offreedom and are used to characterize the rightness or wrongness of thisactor in civil wars. This book traces the history of these figures and theirafterlife. It does so through an int
Leadership is as an integral part of organisational practice that relates to individual or collectivistic forms of decision-making and action that include strategic decision-making, such as how issues are communicated or ‘framed’, and how risk is managed. This article applies a systematic scoping review approach to understand the scope of scholarly literature on human rights leadership and assess
Kallikreins are a family of serine proteases with a range of tissue-specific and essential proteolytic functions. Among the best studied are the prostate tissue-specific KLK2 and KLK3 genes and their secreted protease products, human kallikrein 2, hk2, and prostate-specific antigen (PSA). Members of the so-called classic kallikreins, these highly active trypsin-like serine proteases play establish
Objective: Asthma is divided into various distinct phenotypes on the basis of clinical characteristics, physiological findings, and triggers, and phenotyping is usually performed in a hypothesis-driven univariate manner. However, phenotyping can also be performed using computer algorithms to evaluate hypotheses-free relationships among many clinical and biological characteristics. We aimed to iden
Background: Quality control materials with minimal inter-assay differences and clinically relevant proportions of different molecular forms of the analyte are needed to optimize intra- and inter-laboratory accuracy and precision. Methods: We assessed if clinically relevant total prostate- specific antigen (tPSA) levels were present in seven commercially available Multi Constituent Tumor Marker Con
This work aims to make three-dimensional (3D) tomographic techniques more flexible and accessible to in-situ measurements in practical apparatus by allowing arbitrary camera placements that benefit applications with more restrictive optical access. A highly customizable, in-house developed tomographic method is presented, applying smoothness priors through Laplacian matrices and hull constraints b
Large-scale high-quality van der Waals CoPS3single crystals are synthesized using a chemical vapor transport (CVT) method. The crystallographic structure and electronic properties of this layered material are systematically studied using different spectroscopic methods (XPS, NEXAFS, and resonant photoelectron spectroscopy) accompanied by density functional theory (DFT) calculations. All experiment
Denna avhandling riktar sig mot tre viktiga problem inom kognitiv sjukdom:1) Vi saknar idag kliniska verktyg för att med säkerhet kunna ge en korrekt demensdiagnos. Det enda sättet man med 100 % säkerhet kan avgöra vilken specifik kognitiv sjukdom en person lidit av är genom obduktion och efterföljande undersökning av hjärnan. Endast en liten andel av forskningen inom detta fält rör individer som The first aim of this thesis was to evaluate the prevalence of cardiovascular disease (CaVD), hypertension (HT), and type 2 diabetes mellitus (T2DM) in the neurodegenerative disorders Alzheimer’s disease (AD) and Lewy body disease (LBD). These conditions are considered modifiable risk factors for vascular dementia (VaD), and recent research has proposed its association with AD. The field is consid
Background: Abiraterone acetate (AA) is an androgen biosynthesis inhibitor shown to prolong life in patients with castration-resistant prostate cancer (CRPC) already treated with chemotherapy. AA treatment results in dramatic declines in prostate-specific antigen (PSA) in some patients and no declines in others, suggesting the presence of molecular determinants of sensitivity in tumors. Objective:
Cyclopropane, c-C3H6, the simplest cycloalkane, is seldom included in detailed kinetic mechanisms for hydrocarbons, though it may exhibit unusual kinetic features yet to be analysed due to a lack of studies of its combustion characteristics. In this work, laminar burning velocities of cyclopropane flames have been determined using the heat flux method at atmospheric pressure and an initial gas mix
