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A novel synthesizing procedure is introduced and employed to extract locally-optimal cloaking devices. Their performance is compared with fundamental bounds found using a convex optimization approach. The optimization method is based on a method-of-moments paradigm utilizing rank-1 updates of the structure iteratively performed based on a greedy algorithm. This approach produces locally optimal sh
The contribution of germline copy number variants (CNVs) to risk of developing cancer in individuals with pathogenic BRCA1 or BRCA2 variants remains relatively unknown. We conducted the largest genome-wide analysis of CNVs in 15,342 BRCA1 and 10,740 BRCA2 pathogenic variant carriers. We used these results to prioritise a candidate breast cancer risk-modifier gene for laboratory analysis and biolog
This abstract presents the versatility and computational effectiveness of characteristic mode decomposition based on the transition matrix. The described treatment is valid for all lossless and linear material distributions and is independent of the numerical method used to resolve a particular scattering scenario.
Glaucoma is a leading cause of blindness. Current glaucoma medications work by lowering intraocular pressure (IOP), a risk factor for glaucoma, but most treatments do not directly target the pathological changes leading to increased IOP, which can manifest as medication resistance as disease progresses. To identify physiological modulators of IOP, we performed genome- and exome-wide association an
