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Identification of Asthma Phenotypes in the Spanish MEGA Cohort Study Using Cluster Analysis

Introduction: The definition of asthma phenotypes has not been fully established, neither there are cluster studies showing homogeneous results to solidly establish clear phenotypes. The purpose of this study was to develop a classification algorithm based on unsupervised cluster analysis, identifying clusters that represent clinically relevant asthma phenotypes that may share asthma-related outco

Obesity and the risk of cardiometabolic diseases

The prevalence of obesity has reached pandemic proportions, and now approximately 25% of adults in Westernized countries have obesity. Recognized as a major health concern, obesity is associated with multiple comorbidities, particularly cardiometabolic disorders. In this Review, we present obesity as an evolutionarily novel condition, summarize the epidemiological evidence on its detrimental cardi

Ecology, Agents, and the Causes of Selection : A Reply to Shuker

Shuker points to some inconsistencies in my terminology about consequence laws in evolutionary biology, specifically that gene flow and recombination are not as easily classified as one gets the impression of after reading Sober (1984). I agree, and I also emphasize that evolutionary biology should not only focus on consequence laws, but also source laws arising from the ecological selective envir

Promoting responsible practices in international research collaboration in a multipolar landscape

Over the last few years, just as the COVID-19 pandemic has illustrated the growing need for open international collaboration, increasing geopolitical tensions and politicization of research are leading to higher barriers for transnational scientific cooperation. These deteriorating conditions for inclusive cooperation may hamper both the general advancement of knowledge and, more pointedly, our ab