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The lack of methods to evaluate mechanical function of donated hearts in the context of transplantation imposes large precautionary margins, translating into a low utilization rate of donor organs. This has spawned research into cyber-physical models constituting artificial afterloads (arterial trees), that can serve to evaluate the contractile capacity of the donor heart. The Windkessel model is
Charge transfer states in blends of organic semiconductors have significant importance for the functioning of organic optoelectronic devices, but are also interesting from the perspective of fundamental research as many of their properties as well as their influence on the photophysics of the material are not yet completely understood. We report on a time-resolved photoluminescence study of the ph
NRAS and its effector BRAF are frequently mutated in melanoma. Paradoxically, CRAF but not BRAF was shown to be critical for various RAS-driven cancers, raising the question of the role of RAF proteins in NRAS-induced melanoma. Here, using conditional ablation of Raf genes in NRAS-induced mouse melanoma models, we investigate their contribution in tumour progression, from the onset of benign tumou
The trend for the design of the magnet system for modern synchrotron light sources is moving towards smaller magnet apertures with a reduction of the magnet dimensions as a consequence. There are several reasons for this: to increase the number of focusing cells in a given ring circumpherence to increase the multipole field strengths to reduce the total cost of the magnet and vacuum-systems. This
X-ray parametric amplification is a high order parametric process with the capability to amplify ultrashort laser pulses with broad spectrum ranging from the extreme ultraviolet to the soft x-ray. In this contribution, the dynamics of this broadband amplification schema is studied with sub-20-as temporal resolution by seeding the amplifier with a train of 200-as-long pulses at 11 nm central wavele
The MITF transcription factor and the RAS/RAF/MEK/ERK pathway are two interconnected main players in melanoma. Understanding how MITF activity is regulated represents a key question since its dynamic modulation is involved in the phenotypic plasticity of melanoma cells and their resistance to therapy. By investigating the role of ARAF in NRAS-driven mouse melanoma through mass spectrometry experim
Because global sea level during the last interglacial (LIG; 130–115 ka) was higher than today, the LIG is a useful analogue for improving predictions of future sea level rise. Here, we synthesize sea level proxies for the LIG in the glaciated Northern Hemisphere for inclusion in the World Atlas of Last Interglacial Shorelines (WALIS) database. We describe 82 sites from Russia, northern Europe, Gre
Perfluoroalkyl substances (PFASs) are widespread synthetic substances with various adverse health effects. A potential mechanism of toxicity for PFASs is via epigenetic changes, such as DNA methylation. Previous studies have evaluated associations between PFAS exposure and DNA methylation among newborns and adults. However, no study has evaluated how PFASs influence DNA methylation among children
Preventing the immune escape of tumor cells by blocking inhibitory checkpoints, such as the interaction between programmed death ligand-1 (PD-L1) and programmed death-1 (PD-1) receptor, is a powerful anticancer approach. However, many patients do not respond to checkpoint blockade. Tumor PD-L1 expression is a potential efficacy biomarker, but the complex mechanisms underlying its regulation are no
The production of prompt charmed mesons D0, D+ and D∗+, and their antiparticles, was measured with the ALICE detector in Pb-Pb collisions at the centre-of-mass energy per nucleon pair, (Formula presented.) , of 2.76 TeV. The production yields for rapidity |y| < 0.5 are presented as a function of transverse momentum, pT, in the interval 1–36 GeV/c for the centrality class 0–10% and in the interval
Multi-particle azimuthal cumulants are measured as a function of centrality and transverse momentum using 470 μb−1 of Pb+Pb collisions at sNN = 5.02 TeV with the ATLAS detector at the LHC. These cumulants provide information on the event-by-event fluctuations of harmonic flow coefficients vn and correlated fluctuations between two harmonics vn and vm. For the first time, a non-zero four-particle c
The production of prompt Ds+ mesons was measured for the first time in collisions of heavy nuclei with the ALICE detector at the LHC. The analysis was performed on a data sample of Pb-Pb collisions at a centre-of-mass energy per nucleon pair, (Formula presented.) , of 2.76 TeV in two different centrality classes, namely 0–10% and 20–50%. Ds+ mesons and their antiparticles were reconstructed at mid
