The relationship between inflammation and proteolytic activation in pancreatitis is an unresolved issue in pancreatology. The purpose of this study was to define the influence of neutrophils on trypsinogen activation in severe AP. Pancreatitis was induced by infusion of taurocholate into the pancreatic duct in C57BL/6 mice. For neutrophil depletion, an anti-Gr-1 antibody was administered before pa

AIMS: Adult mammalian cardiomyocytes are traditionally viewed as being permanently withdrawn from the cell cycle. While some groups have reported none, others have reported extensive mitosis in adult myocardium under steady state conditions. Recently, a highly specific assay of (14)C dating in humans has suggested a continuous generation of cardiomyocytes in the adult, albeit at a very low rate. M

Trabecular bone score (TBS) is a grey-level textural index of bone microarchitecture derived from lumbar spine dual-energy X-ray absorptiometry (DXA) images. TBS is a BMD-independent predictor of fracture risk. The objective of this meta-analysis was to determine whether TBS predicted fracture risk independently of FRAX probability and to examine their combined performance by adjusting the FRAX pr

BACKGROUND: Iron deficiency may impair aerobic performance. This study aimed to determine whether treatment with intravenous iron (ferric carboxymaltose) would improve symptoms in patients who had heart failure, reduced left ventricular ejection fraction, and iron deficiency, either with or without anemia. METHODS: We enrolled 459 patients with chronic heart failure of New York Heart Association (

The 4th generation of district heating systems face a potential problem where lowered water temperatures lead to higher flow rates, which requires higher hydraulic capacity in terms of pipe and pump sizes. This increases the effect of the already existing issue of hydraulic bottlenecks, causing peripheral units (customers) to experience reduced flow rates. A coordinating control strategy is presen

Aims: Mineralocorticoid receptor antagonists (MRAs) improve outcomes in heart failure with reduced ejection fraction (HFrEF) but remain underused and are often discontinued especially in patients with chronic kidney disease (CKD) due to concerns on renal safety. Therefore, in a real-world HFrEF population we investigated the safety of MRA use, in terms of risk of renal events, any mortality and an

Lignocellulosic biomass represents the most abundant renewable carbon source on earth and is already used for energy and biofuel production. The pivotal step in the conversion process involving lignocellulosic biomass is pretreatment, which aims to disrupt the lignocellulose matrix. For effective pretreatment, a comprehensive understanding of the intricate structure of lignocellulose and its compo

The food industry is vital manufacturing sector globally, with an ever-increasing reliance on digitalisation and technology-driven processes. However, this advancement introduces inherent cyberattack risks, encompassing data breaches and system disruptions, which can severely impact production and disrupt the entire food chain. Consequently, cyber threats can evoke fear and mistrust among consumer

AIMS: Heart failure (HF) patients with anaemia tend to have a worse outcome, with increased hospitalization rates, decreased exercise tolerance, and higher mortality compared to those without anaemia. Limited research exists on the association between selenium deficiency and anaemia specifically in HF patients, despite previous findings of a correlation in different populations. The BIOSTAT-CHF st

Background: In image processing for activity quantification, the end goal is to produce a metric that is independent of the measurement geometry. Photon attenuation needs to be accounted for and can be accomplished utilizing spectral information, avoiding the need of additional image acquisitions. The aim of this work is to investigate the feasibility of 177Lu activity quantification with a small

Transport electrification in Sweden is moving at a fast pace. Grid impact studies from EVs predominantly consider low-voltage grids. However, as the share of electric cars is rapidly increasing, potential grid impact at higher voltage levels needs to be considered. This paper presents a probabilistic approach to generate aggregated charging profiles for home charging at a sub-transmission grid lev

This paper deals with the performance evaluation of a high speed axial flux switched reluctance motor for automotive traction applications. The motor makes use of a novel axial flux segmented rotor topology. The main aim of the design is to push the continuous power density as high as possible. The high speed nature of the design and the resulting high electrical frequency, as well as the machine

Conductive electric road systems are charging in-frastructures that allow electric vehicles to charge while driving. Similar to that of trolleybuses, trams and metro trains conductive electric roads use a physical sliding contact to facilitate the energy transfer between vehicle and road supply. However, as conductive electric roads introduce a new application for the sliding contact, knowledge is