Filtyp
PI Christer Larsson Our researchOur aims are to identify and understand mechanisms regulating breast cancer cell death and how inflammatory signaling can be induced and influence breast cancer progression. We specifically study Smac mimetics, small molecules mimicking the effect of the pro-apoptotic protein Smac. We investigate determinants of Smac-responsiveness and ways to circumvent resistance
https://www.tcr.lu.se/research-groups/tumor-cell-biology - 2025-10-03
PI Charlotte Rolny ResearchOur research primarily focuses on tumor immunology, with a particular emphasis on understanding the behavior of Tumor-Associated Macrophages (TAMs) and is dedicated to finding novel targets that reprogram immunosuppressive and pro-metastatic Tumor-Associated Macrophages into an anti-tumor phenotype. Our lab employs state-of-the-art molecular biology techniques, mouse mod
https://www.tcr.lu.se/research-groups/immuno-oncology-group - 2025-10-03
Swedish Research Council (VR)Swedish Cancer SocietyWenner-Gren foundationsThe Swedish Childhood Cancer FoundationFru Berta Kamprads stiftelse
https://www.tcr.lu.se/research-groups/immuno-oncology-group/funding - 2025-10-03
VEGF-C-expressing TAMs rewire the metastatic fate of breast cancer cells.Banerjee K, Kerzel T, Bekkhus T, Ferreira de Souza S, Wallmann T, Wallerius M, Landwehr LS, Agardy DA, Schauer N, Malmerfeldt A, Bergh J, Bartish M, Hartman J, Östman A, Squadrito ML and Rolny C. Cell Reports. 2023 Dec 1;42(12):113507. doi: 10.1016/j.celrep.2023.113507 MNK2 governs the macrophage antiinflammatory phenotype.B
https://www.tcr.lu.se/research-groups/charlotte-rolny/selected-publications - 2025-10-03
PI Daniel Bexell Our researchOur research is about childhood cancer neuroblastoma. We work to understand the mechanisms leading to metastasis and treatment resistant relapse, and to test new treatment against aggressive neuroblastoma. Our projects encompass studies on basic tumor biology as well as preclinical and translational studies with the aim to find novel treatments. We perform molecular an
https://www.tcr.lu.se/research-groups/molecular-pediatric-oncology - 2025-10-03
Team members
https://www.tcr.lu.se/research-groups/medical-molecular-biology/ceder-lab - 2025-10-03
PI Ramin Massoumi Our researchThe overall goal of our research is to characterize the function of certain genes in development biology and immunology. In addition, we try to identify driver genes that are defined as being linked to human diseases such as cancer and fibrosis. Dissecting the signalling pathway with the focus on the post-translational modifications, will allow us to identify potentia
https://www.tcr.lu.se/research-groups/molecular-tumor-pathology - 2025-10-03
PI Alexander Pietras BackgroundGlioblastoma multiforme (GBM) the highest-grade glioma and deadliest brain tumor occurs in pediatric as well as adult patients. Despite aggressive treatment with surgery, irradiation and sometimes chemotherapy, tumors invariably recur as incurable lesions. Tumor cells with stem cell characteristics are thought to be responsible for therapeutic resistance in brain tum
https://www.tcr.lu.se/research-groups/brain-tumor-biology - 2025-10-03
Our research
https://www.tcr.lu.se/development-biology - 2025-10-03
PI Kristian Pietras Our researchOur aim is to molecularly map support functions performed by the various cell types comprising the tumor microenvironment. We believe that decisive treatment benefit can only be achieved by targeting several of the cell types that collectively sustain tumor growth. Importantly, the cellular networks within tumors cannot be studied in isolation. Thus, our work ranges
https://www.tcr.lu.se/research-groups/experimental-oncology - 2025-10-03
PI Lars Rönnstrand BackgroundThe receptor tyrosine kinases KIT and FLT3 are both important regulators of development and maintenance of a number of different cell types. Deregulation of these receptors by mutations has been implicated in various human malignancies, including akut myeloid leukemia and melanoma. The signaling pathways activated by the oncogenic mutants are to some extent unique and
https://www.tcr.lu.se/research-groups/molecular-cancer-research - 2025-10-03
PI Kazi Julhash Uddin BackgroundDespite incredible progress in the treatment of cancer, the cure rate remains low due to the fact that almost all cancer patients develop resistance to anticancer therapies. This results in as many as 90% of cancer-related deaths in various types of cancer. Consequently, identification of the factors that drive the development of therapy resistance is a pressing is
https://www.tcr.lu.se/research-groups/molecular-cancer-medicine - 2025-10-03
For many double stranded (ds) DNA viruses the viral genome is actively packaged into the virus capsid by a powerful molecular motor. This results in an energetically unfavorable state of the packaged genome, creating tens of atmospheres internal pressure inside the virion. Using a new calorimetric assay to determine the activation energy barriers associated with genome loss in response to elevated
https://www.virus-biophysics.lu.se/covers-highlights-0 - 2025-10-03
For many double stranded (ds) DNA viruses the viral genome is actively packaged into the virus capsid by a powerful molecular motor. This results in an energetically unfavorable state of the packaged genome, creating tens of atmospheres internal pressure inside the virion. Using a new calorimetric assay to determine the activation energy barriers associated with genome loss in response to elevate
https://www.virus-biophysics.lu.se/covers-movies-and-highlights - 2025-10-03
ALEX EVILEVITCH RESEARCH GROUP We are always interested in reviewing applications from MSc students, prospective PhD students and postdocs. Project description Herpesviruses are a leading cause of human viral disease. Herpesviruses consist of a double-stranded DNA genome contained within a protein shell, termed the capsid, that is surrounded by an unstructured protein layer and a lipid-envelo
https://www.virus-biophysics.lu.se/open-positions-0 - 2025-10-03
Virus Biophysics Virus Biophysics is a rather new field that seeks to define the physical mechanisms controlling virus development. This knowledge can provide information essential to the rational design of new antiviral strategies with less specificity for a limited number of viruses. Furthermore, biological and physical simplicity relative to other biological systems have made viruses an attract
https://www.virus-biophysics.lu.se/research-overview - 2025-10-03
News and Events January 9, 2024 , Physics World "Viruses change structure at the temperature of the human body to better infect us". If you want to know in simple words a possible mechanism of viral genome delivery, read more in this link (it opens a new webpage).November 8, 2023, Lund University press release on our pioneering study published in PNAS showing how temperature triggers release of v
https://www.virus-biophysics.lu.se/node/137 - 2025-10-03
Herpes Simplex 1 pressurized DNA release into a cell nucleus. DNA packaging and capsid reinforcement Illustration and poem inspired by graduate student Krista Freeman's contributions to “The Invisible Jazz Experimental Laboratories”, hosted by The Space Upstairs in Pittsburgh, PA."I've optimized my eyes to fill my brain with dissonance in a balance. The information is a bomb, every fact a potenti
https://www.virus-biophysics.lu.se/movies-artwork - 2025-10-03
Our Biophysical ToolsOur research group investigates mechanics of viral replication, virus-host interactions, virus assembly and disassembly within the host. Specifically, we investigate energetics, structure and mobility of the intra-capsid genome as well as mechanical properties of viral capsids, influenced by changes in physiological environment that are important for viral replication. Main to
https://www.virus-biophysics.lu.se/methods-and-techniques - 2025-10-03
Principal Investigator: Alex Evilevitch, PhDProfessor of Cell Biology Email: Alex [dot] Evilevitch [at] med [dot] lu [dot] se Lab photos Postdocs José Ramón Villanueva Valencia, PhDEmail: jose_ramon [dot] villanueva-valencia [at] med [dot] lu [dot] se (jose_ramon[dot]villanueva-valencia[at]med[dot]lu[dot]se) Santosh Gawali, PhD Email: santosh [dot] gawali [at] med [dot] lu [dot] se G
https://www.virus-biophysics.lu.se/people - 2025-10-03
