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Idiopathic pulmonary fibrosis (IPF) and lung cancer represent progressive lung diseases with a poor prognosis. IPF represents a risk factor for the development of lung cancer, and the incidence of lung cancer is increased in patients with IPF. Disease pathogenesis of IPF and lung cancer involves common genetic alterations, dysregulated pathways, and the emergence of hyperplastic and metaplastic ep

Lung cancer and chronic lung diseases impose major disease burdens worldwide and are caused by inhaled noxious agents including tobacco smoke. The cellular origins of environmental-induced lung tumors and of the dysfunctional airway and alveolar epithelial turnover observed with chronic lung diseases are unknown. To address this, we combined mouse models of genetic labeling and ablation of airway

Investigating Romanian radical right populism, I evidence the gendered nature of conceptual metaphors and provide insights on the specific masculinities that they underpin in such political discourses. With the 2004 presidential elections as a backdrop, the analysis focuses on how the radical right populist candidates articulated in their discourses the conceptual metaphor of the "strict father."

This article investigates the discursive opportunities for radical-right populist politics in Hungary and Romania. We argue that it is important to assess whether the discursive activities of radical-right media are reflected and included in the chains of discussion in the public sphere. The involvement and visibility of radical-right media in news coverage is considered a cue for their acceptance

This article employs a two-level analysis to compare the discursive performance of gender on social media in Hungary and Romania; the two countries with the lowest percentage of women in politics in the European Union (EU). First, by revealing the tension between conservative views about gender roles, and social and political specificities in the two countries, the research illustrates how various

This study analyses the populist radical right discourse of the Sweden Democrats (Sverigedemokraterna, SD), examining how Jimmie Åkesson, the SD chairperson, conceptualized gendered social positions in the folkhem ([Swedish] people’s home) in his annual speeches in Almedalen, since the SD entered the Swedish Parliament in 2010 to date. Attention is being paid to whose voices are allowed to come fo

The article scrutinises a version of welfare chauvinism taking shape in Sweden, by concentrating on the concept of folkhem (the [Swedish] people’s home), and examines how it was expressed in the 2010–2014 parliamentary activity of the Sweden Democrats. It offers an analysis of how the welfare chauvinism project is first contextualised in the party documents, and subsequently articulated in the par

The present article investigates the recent history of the Romanian national construct as a matrix for gendered metaphors at the beginning of the twenty-first century, as it is heralded by the main radical-right populist party the Greater Romania Party (Partidul România Mare, PRM). Focusing on the Greater Romania Magazine (Revista România Mare, RRM) - the party's main media outlet - the analysis i

Within barely a year, two school shootings shook Finland. The school shootings shocked Finnish society, forcing media, academics and experts, police and politicians alike to search for reasons behind the violent incidents. Focusing their analysis on the two main Finnish newspapers, Helsingin Sanomat and Hufvudstadsbladet, authoritative sources of information for Finland's two language communities,

Protein Arp, the IgA-binding protein of the group A Streptococcus, has affinity for the Fc-part of IgA. The binding between protein Arp and several different molecular forms of human IgA was characterized. It was found that protein Arp bound with higher affinity to uncomplexed forms of IgA than to complexed forms (secretory IgA, alpha 1-antitrypsin-IgA and alpha 1-microglobulin-IgA). Thus, the aff

alpha 1-Microglobulin, a plasma protein with immunoregulatory properties, and bikunin, the light chain of the proteinase inhibitors inter-alpha-inhibitor and pre-alpha-inhibitor, are translated as a precursor protein from the same mRNA. The cosynthesis of alpha 1-microglobulin and bikunin is unique compared to other proproteins such as procomplement components and prohormones, since alpha 1-microg

Cell surface proteins that bind to the Fc part of Ig are expressed by many strains of group A streptococci, an important human pathogen. Two such bacterial strains, AP4 and AP1, were shown to bind IgA and IgG, respectively, in a temperature-dependent manner. The binding of radiolabeled Ig to the bacterial cells was lower at 37 degrees C than at 22 and 4 degrees C. Similarly, protein Arp, the IgA-b