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Pharmacodynamics of moxifloxacin against Streptococcus pyogenes in an in vitro kinetic model

The aim of the present study was to investigate the pharmacodynamics of moxifloxacin against strains of Streptococcus pyogenes with different susceptibilities to erythromycin by using an in vitro kinetic model simulating human pharmacokinetics of moxifloxacin at oral doses of 400 and 200 mg, respectively. When the different strains of S. pyogenes were exposed to the higher dose, the number of bact

Epidemiology, clinical presentation, and pathophysiology of atypical and recurrent hemolytic uremic syndrome

Hemolytic uremic syndrome (HUS) includes a heterogeneous group of hemolytic disorders. Among the identified causes of HUS are infections, particularly infections with Shiga toxin-producing ESCHERICHIA COLI (STEC), complement disorders, and disorders interfering with the degradation of von Willebrand factor (VWF). Other causes for atypical HUS include the cobalamin metabolism; pregnancy/hemolysis,

The Littorina transgression in southeastern Sweden and its relation to mid-Holocene climate variability

Popular Abstract in Swedish Den senglaciala och Holocena strandförskjutningen i Östersjön har sin grund i samspelet mellan den isostatiska landhöjningen och den eustatiska havsyteförändringen, vilka är orsakade av den senaste inlandsisens tillväxt och avsmältning. Detta samspel ledde till relativa förändringar av vattenytan i världshaven och har medfört att den nuvarande Östersjön tidvis varit isoLateglacial and Holocene shoreline displacement along the Baltic coast resulted from both the isostatic land uplift and the ice-volume-equivalent sea-level rise. Relative changes of these two components led to alternating contact/isolation of the Baltic Basin with the North Sea during the Holocene. The Littorina transgression was a significant palaeoceanographic change that took place during the m

Interchain photoluminescence in substituted polyfluorenes

We have characterised the interchain emitting states of two substituted polyfluorenes with steady-state and time-resolved photoluminescence (PL). Site selective excitation of the interchain state shows that physical dimers are formed in the film. These dimers have low concentration in the films but exciton diffusion to the dimers is reducing the intrachain exciton lifetime. With asymmetrical subst

Retinal neurospheres prepared as tissue for transplantation

The present work was conducted to study the cellular composition and developmental capacity of retinal neurospheres. Furthermore, the ability of grafted neurospheres to integrate into adult retinal tissue was studied in an in vitro model. Retinal progenitor cells isolated from rat embryos were expanded into neurospheres in vitro in the presence of basic fibroblast growth factor (bFGF), epidermal g

Closing the Information Loop in Recipe-Based Batch Production

In addition to the basic regulatory functions, a batch control system must support production planning and scheduling, recipe management, resource allocation, batch report generation, unit supervision and exception handling. A closed-loop framework is presented in this work that integrates decision support tools required at the different levels of a decision-making hierarchical batch control syste

Exploring the "Culture of Non-Payment" in the post-apartheid South Africa

”Residents are refusing to pay until an effort is made to clean up, while authorities are refusing to remove refuse until residents pay”. This is the front-page headline of a prominent morning newspaper in Cape Town, South Africa that strikes to the core of what this research seeks to explore. For somewhere between this deadlock lurks a social phenomenon, the “culture of non-payment” borne as a re

Rotational CARS thermometry at high temperature (1800 K) and high pressure (0.1-1.55 MPa)

Dual-broadband rotational CARS (DB-RCARS) thermometry has been investigated at high temperature and high pressure. Single-shot measurements were performed at 1800 K, in air and nitrogen at pressures up to 1.55 MPa and in oxygen at pressures up to 0.5 MPa. For all conditions, the resonant signal contribution to the spectra clearly dominated over the non-resonant one, implying the high potential for

IN-BEAM SPECTROSCOPY AT THE PROTON-DRIP LINE - FIRST OBSERVATION OF EXCITED-STATES IN SB-106 AND SB-107

Neutron deficient nuclei close to Sn-100 have been investigated in-beam using the NORDBALL detector array. A target of Fe-54 was bombarded with a beam of Ni-58 at 270 MeV. Evaporation residues were identified by detecting protons and alpha particles in a 4 pi charged particle multi-detector set-up and neutrons in a 1 pi neutron detector wall in coincidence with gamma rays. Excited states of the pr

Robust factorization

Factorization algorithms for recovering structure and motion from an image stream have many advantages, but they usually require a set of well-tracked features. Such a set is in generally not available in practical applications. There is thus a need for making factorization algorithms deal effectively with errors in the tracked features. We propose a new and computationally efficient algorithm for

Peripheral bone mineral density and different intensities of physical activity in children 6-8 years old: The Copenhagen School Child Intervention Study

This study aimed to evaluate the association between objectively measured habitual physical activity and calcaneal and forearm bone mineral density (BMD, g/cm(2)), one mechanically more loaded and one less loaded skeletal region, in children aged 6-8 years. BMD was measured in 297 boys and 265 girls by peripheral dual-energy X-ray absorptiometry in the forearm and calcaneus. An accelerometer regis

Perinatal factors associated with cerebral palsy in children born in Sweden.

OBJECTIVE: To identify perinatal factors associated with cerebral palsy (CP). METHODS: This was a case-control study based on the Swedish Medical Birth Registry and the Swedish Hospital Discharge Registry, including 2,303 infants born in Sweden 1984-1998 with a diagnosis of CP and 1.6 million infants without this diagnosis. Odds ratios (ORs) with 95% confidence intervals (Cis) were calculated. RES