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Cationic surfactants with one alkyl chain have offered a particularly efficient control of the properties of DNA-based particles. However, most transfection lipids do not form micelles as single-chain surfactants. In this work, the formation of DNA gel particles mixing DNA (either single- (ssDNA) or double-stranded (dsDNA)) with the vesicle-forming double chain surfactant didodecyldimethylammonium

This paper investigates practical aspects associated to the adoption of dynamic spectrum management (DSM) in existing digital subscriber lines (DSL) access networks. A standard-compliant crosstalk estimation method is utilized in order to retrieve the crosstalk channel information needed by, e.g., a DSM level 2 system. A DSM application framework was developed to help testing DSM in practice and i

To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2.9 x 10(-6)) mapped 188 kb downstream of MC4R (melanocortin-4 receptor), mutations of which are the leading cause of monogenic severe childhood-onset obesity

Differences in the expression of non-motor symptoms (NMS) by Parkinson's disease (PD) patients may have important implications for their management and prognosis. Gender is a basic epidemiological variable that could influence such expression. The present study evaluated the prevalence and severity of NMS by gender in an international sample of 951 PD patients, 62.63% males, using the non-motor sy

Climate change and disasters pose a serious risk to sustainable development. In the South local coping strategies are an important element of adaptation to climate and disaster risk. Such strategies have arisen because of the limited assistance provided by urban actors and associated social security and governance systems. In contrast, in the North local coping strategies are comparatively poorly

We review some recent results on the exact asymptotics of the components in the inhomogeneous random graph models of rank 1. We discuss the relevance of these results to the analysis of random walk on random graphs.

In this paper, we present a new modular approach to immobilize boronic acid ligands that can offer effective separation of glycoproteins. A new "clickable" boronic acid ligand was synthesized by introducing a terminal acetylene group into commercially available 3-aminophenyl boronic acid. The clickable ligand, 3-(prop-2-ynyloxycarbonylamino)phenylboronic acid (2) could be easily coupled to azide-f

A mild, efficient, Lewis acid promoted addition of C3-substituted 1,3-bis(silyl)propenes to aldehydes to provide the corresponding 2,3,4,5-tetrasubstituted tetrahydrofurans in excellent stereoselectivity is reported. (C) 2013 Elsevier Ltd. All rights reserved.

B-cell leukemia 3 (Bcl-3) is a member of the inhibitor of κB family, which regulates a wide range of biological processes by functioning as a transcriptional activator or as a repressor of target genes. Elevated expression, sustained nuclear accumulation, and uncontrolled activation of Bcl-3 causes increased cellular proliferation or survival, dependent on the tissue and type of stimuli.

Partial preferences may occur due to differences in profitability and encounter probability between food types within a patch. In the expanding specialist diet strategy, a forager goes from being partially selective on the preferred, most profitable food, to being opportunistic, after the preferred food has been depleted to a certain critical level. We studied the diet selection strategies of bird

In recent years the use of repetition rate multiplication (RRM) on direct geometry neutron spectrometers has been established and is the common mode of operation on a growing number of instruments. However, the chopper configurations are not ideally optimised for RRM with a resultant 100 fold flux difference across a broad wavelength band. This paper presents chopper configurations that will produ

An improved synthetic route to the bicyclo[2.2.2]octane-2,6-diol ligands (2,6-BODOLS) allowed an increased structural variation of the ligand side-arm. The addition of aromatic or vinylic Grignard reagents to hydroxyketone 1 was highly selective and ligands 3f-3I were isolated in 84-97% yield. The addition of alkyl Grignard reagents containing beta-hydrogens resulted in lower yields (13-71%) due t

Background: Stroke is a major cause of mortality and morbidity across the world. Air pollution has become an acknowledged risk factor for stroke, especially for acute effects. There is less support for effects by chronic exposure due to the methodological challenges inherent in such studies. Such challenges can regard missing individual level data or residual confounding and can partly be overcome

Background: Breast cancer is the most common malignancy afflicting women, and the most common cancer overall in Jordan. A woman's decision to go for screening is influenced by her social support network. This study aims to explore Jordanian men's individual and contextual perspectives on women's breast cancer and their own role in the breast health of the females within their families. Methods: An

This article presents how food consumption has become an important part of modern football and the way in which commercialization of football clubs is perceived by supporters. Taking the Swedish club Malmö FF as an example, the article explores how the straightforward pattern of consumerism is problematized as fans are able to express a strong feeling of co-creation and even ownership of their bel

Little in general is known about how heme proteins are assembled from their constituents in cells. The Gram-positive bacterium Enterococcus faecalis cannot synthesize heme and does not depend on it for growth. However, when supplied with heme in the growth medium the cells can synthesize two heme proteins; catalase (KatA) and cytochrome bd (CydAB). To identify novel factors important for catalase

Electron transfer (ET) reactions of truncated hemoglobin from Bacillus subtilis (trHb-Bs) are suggested to be implicated in biological redox signalling and actuating processes that may be used in artificial environment-sensing bioelectronic devices. Here, kinetics of ET in trHb-Bs covalently attached via its surface amino acid residues either to COOH- or NH2-terminated (CH2)(2-16) alkanethiol SAM