Sökresultat

Filtyp

Din sökning på "*" gav 557508 sökträffar

The GARDpotency Assay for Potency-Associated Subclassification of Chemical Skin Sensitizers—Rationale, Method Development, and Ring Trial Results of Predictive Performance and Reproducibility

Proactive identification and characterization of hazards attributable to chemicals are central aspects of risk assessments. Current legislations and trends in predictive toxicology advocate a transition from in vivo methods to nonanimal alternatives. For skin sensitization assessment, several OECD validated alternatives exist for hazard identification, but nonanimal methods capable of accurately c

Validation of the GARD™skin Assay for Assessment of Chemical Skin Sensitizers : Ring Trial Results of Predictive Performance and Reproducibility

Proactive identification of chemicals with skin sensitizing properties is a key toxicological endpoint within chemical safety assessment, as required by legislation for registration of chemicals. In order to meet demands of increased animal welfare and facilitate increased testing efficiency also in nonregulatory settings, considerable efforts have been made to develop nonanimal approaches to repl

GARD : An in vitro platform for toxicological assay development

Life in modern society is intricately intertwined with the results of continuous technological advances. Thishas given rise to daily routines where people are frequently exposed to a wide variety of chemicals.Though many of the chemicals do not generally induce adverse health effects upon normal exposure,several of them has the potential to negatively impact health. Indeed, in order to create prod

Assessing glacier retreat and its impact on water resources in a headwater of Yangtze River based on CMIP6 projections

Glacier retreat caused by global warming alters the hydrological regime and poses far-reaching challenges to water resources and nature conservation of the headwater of Yangtze River, and its vast downstream regions with dense population. However, there is still lack of a robust modeling framework of the “climate-glacier-streamflow” in this water tower region, to project the future changes of glac

Message Sent, Now What? A Critical Analysis of the Heat Action Plan in Ahmedabad, India

To protect public health, heat-related policies are increasingly being adopted by city authorities to address the unequal impact of heatwaves. Ahmedabad’s Heat Action Plan (HAP) is an acclaimed and successful policy response in India and beyond. While the pilot evaluation of the initiative suggests that almost a thousand deaths were avoided annually after its implementation, it is not yet clear wh

Multi-camera platform calibration using multi-linear constraints

We present a novel calibration method for multi-camera platforms, based on multi-linear constraints. The calibration method can recover the relative orientation between the different cameras on the platform, even when there are no corresponding feature points between the cameras, i.e. there are no overlaps between the cameras. It is shown that two translational motions in different directions are

Factorization with erroneous data

Factorization algorithms for recovering structure and motion from an image stream have many advantages, but traditionally requires a set of well tracked feature points. This limits the usability since, correctly tracked feature points are not available in general. There is thus a need to make factorization algorithms deal successfully with incorrectly tracked feature points. We propose a new compu

Resonant X-ray Raman scattering involving avoided crossings in the final-state potential-energy curves

The effect of avoided crossings on the spectral profiles of resonant X-ray Raman scattering was investigated. The theory was also applied to nitrogen molecule in the core-excited level to analyze the electron decay process. The dependence of internuclear distance on electron transition amplitude was considered important with respect to the breakdown process of the transition. The correlation betwe

Bond-distance-dependent decay probability of the N 1s→π* core-excited state in N2

We report the observation of the unusually weak decay of the N 1s→π* core-excited N2 molecule to the B 2Σu+ final state of N2+, which is only detectable in an experiment with high sensitivity. The resonant Auger spectra exhibit an unexpected dependence on the selected vibrational level of the intermediate state. Theoretical calculations show that the interference between direct and resonant photoe

I Could Visit Her Blog Just Because She’s so Stupid : A Study of how Gendered Norms and Discourses Surrounding Girls’ Blogging Habits are Created and how the Girls’ Negotiate Around Them

General introduction This publication is the end product of the Invisible Girl project, an international, Swedish­based and multi­disciplinary research project in which the interplay of power relations, gender, and age was the primary object of study. The project was global in its scope and included researchers and artists from Australia, Canada, Croatia, The Czech Republic, Estonia, India, Israel

Effects of scale on multimodal deixis : Evidence from Quiahije Chatino

As humans interact in the world, they often orient one another's attention to objects through the use of spoken demonstrative expressions and head and/or hand movements to point to the objects. Although indicating behaviors have frequently been studied in lab settings, we know surprisingly little about how demonstratives and pointing are used to coordinate attention in large-scale space and in nat

Rate differences between first and second primary cancers may outline immune dysfunction as a key risk factor

Background: Many cancers are increased in immunosuppressed patients and evidence is accumulating that immune dysfunction may be a contributing risk factor for second primary cancers (SPCs). The aim of this study was to explore the potential influence of immune mechanisms in SPC. Methods: We used the Swedish Cancer Registry (1990-2015) to select 13 male and 14 female first primary cancers (FPCs) th

Microbiomes in a manganese oxide producing ecosystem in the Ytterby mine, Sweden : impact on metal mobility

Microbe-mediated precipitation of Mn-oxides enriched in rare earth elements (REE) and other trace elements was discovered in tunnels leading to the main shaft of the Ytterby mine, Sweden. Defining the spatial distribution of microorganisms and elements in this ecosystem provide a better understanding of specific niches and parameters driving the emergence of these communities and associated minera

The power of empirical data; lessons from the clinical registry initiatives in Scandinavian cancer care

Background: In Scandinavia, there is a strong tradition for research and quality monitoring based on registry data. In Denmark, Norway and Sweden, 63 clinical registries collect data on disease characteristics, treatment and outcome of various cancer diagnoses and groups based on process-related and outcome-related variables. Aim: We describe the cancer-related clinical registries, compare organiz

Challenging conceptualisations of work : Revisiting contemporary experiences of return to work and unemployment

This article draws on empirically derived illustrations of return to work and unemployment to critically explore how a narrow understanding of work pervades contemporary social policies and programmes. This is particularly relevant in economic and labour market transitions aligned with neoliberalism that individualise the social problem of unemployment and thus restrict occupational possibilities