Despite recent progress, therapy for metastatic clear cell renal cell carcinoma (CCRCC) is still inadequate. Dysregulated Notch signaling in CCRCC contributes to tumor growth, but the full spectrum of downstream processes regulated by Notch in this tumor form is unknown.

ABSTRACT: BACKGROUND: Medical emigration from developing to developed countries is a well established phenomenon of substantial importance. Though Libya is classified as an upper-middle income country, it has been affected by this trend. This study was undertaken to identify some of the possible reasons behind the emigration of Libyan doctors and factors that might motivate them to return. FINDING

Since their introduction to the toad-free Australian continent cane toads (Bufo marinus) have caused a dramatic increase in naïve varanid mortality when these large lizards attempt to feed on this toxic amphibian. In contrast Asian-African varanids, which have coevolved with toads, are resistant to toad toxin. Toad toxins, such as Bufalin target the H1-H2 domain of the α(1) subunit of the sodium-p

The development of Graves' disease (GD) after subacute thyroiditis (SAT) is very rare and only a limited number of cases have been reported.

Popular Abstract in Swedish Svenska räkneord behandlas här ur olika synvinklar. Boken är inte tänkt som en lärobok om svenska räkneord, även om man kan lära sig en hel del om systemet här - mer än språkanvändaren i allmänhet känner till. Fonologi, morfologi, syntax och semantik får alla sin del av uppmärksamheten. Jag undersöker räkneordssystemet som en synkron helhet, men de historiska förhållandSwedish numerals are here treated from different points of view. The book is however not intended to be a textbook of Swedish numerals, though one may learn a great deal about the system herein - more than the general user of the language knows. Phonology, morphology, syntax and semantics all get their fair share of attention. I am investigating the numeral system as a synchronic whole (and simila

A critical note on the responsibility of the environment at a department.

Bruton's agammaglobulinemia tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase important in B-lymphocyte development, differentiation, and signaling. Btk is a member of the Tec family of kinases. Mutations in the Btk gene lead to X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (Xid) in mice. Activation of Btk triggers a cascade of signaling events that culminates in t

Uppsatsen presenterar utförligt den grönbok kommissionen utfärdade 1995 inför den framtida revideringen av vertikala avtal och analyserar effekterna av de fyra alternativa förslag som grönboken innehåller. Uppsatsen pekar på att den strikt formella hållning som gemenskapspraxis dittills utvecklat inte befrämjar en sund ekonomisk utveckling. Inte minst är den ensidiga betoningen av integrationsaspe

The fact that Sweden has been spared from war on its soil for almost 200 years, has not stopped Swedish citizens from participating in conflicts worldwide during this period. This has been described, especially from the soldiers perspective. The contribution of Swedish physicians has not been written about to the same extent. When Mussolini's Italy in October 1935 invaded the poor and underdevelop

For the working muscle there are a number of fuels available for oxidative metabolism, including glycogen, glucose and non-esterified fatty acids. Non-esterified fatty acids originate from lipolysis in white adipose tissue, from hydrolysis of VLDL-triglycerides or from hydrolysis of intramyocellular triglyceride stores. A key enzyme in the mobilization of fatty acids from intracellular lipid store

Two neonates with proximal dorsal swelling and skin necrosis had median, ulnar, and particularly radial nerve palsies after birth, which was interpreted as compartment syndrome in the forearm. The swelling in case 1 disappeared, the skin lesion in case 2 healed, and the functions of nerves recovered almost completely in both cases, although the forearm and hand in the second patient were shorter a

BACKGROUND: Several animal studies have raised concern about the risk for obstructive azoospermia owing to vasal fibrosis caused by the use of alloplastic mesh prosthesis in inguinal hernia repair. The aim of this study was to determine the prevalence of male infertility after bilateral mesh repair. METHODS: In a prospective study, a questionnaire inquiring about involuntary childlessness, investi

Relationen mellan de levande och döda kroppar är tvetydig bland svenskar i allmänhet. Å ena sidan fins ett avståndstaagande till den döda kroppen. Den tas om hand av specialister i speciella lokaler för döda. Å andra sidan ger många uttryck för en närhet till den döda kroppen. Den avlidnes identitet hör nära samman med det liv som just levts på jorden, och inte med ett himmelskt liv efter döden. K