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An eternally grateful refugee? : Silences in Swedish public discourse and the (de)historicization of Polish-Swedish activist Ludwika Broel-Plater

This chapter examines how the history and legacy of Polish-Swedish activist Ludwika Broel-Plater have been obscured in Swedish public discourse, in which she is recognized mainly as a passive and grateful recipient of Swedish humanitarianism. The first part of the chapter examines silences that have entered narrative constructions in Swedish public discourse about survivors who came to Sweden as r

Infections, antigen-presenting cells, T cells, and immune tolerance : their role in the pathogenesis of immune thrombocytopenia

In the last 20 years, many publications have shed new light on the complex immunopathogenesis of immune thrombocytopenic purpura. They are associated with 3 interrelated areas of environmental autoimmunity, for example, infectious influences, antigen-presenting cell (APC) function, and T-cell abnormalities, particularly tolerance induction. This article highlights the recent literature and argues

Management of acute mesenteric ischaemia in adult patients : a systematic review and meta-analysis

Background: Guidance on managing acute mesenteric ischaemia (AMI) is largely based on expert opinion and retrospective studies pooling different subtypes of AMI. In clinical practice, management strategy is often selected based on the patient’s severity of illness, whereas randomized controlled trials or even adjusted analyses comparing different strategies are rarely available. We aimed to perfor

Validation of POD24 as a robust early clinical indicator of poor survival in mantle cell lymphoma from 1280 patients on clinical trials, a LYSA study

In mantle cell lymphoma, early progression of disease has been associated with short overall survival. The impact of clinical, pathological, and treatment strategies on the risk of early relapse has not been assessed in a large cohort of patients. We performed a pooled analysis of patients recruited in France from six randomized first-line MCL trials. Among 1386 treated MCL patients, 1280 were eva

Flexible fabrication of aligned multi-nanowire circuits for on-chip prototyping

Circuits of multiple deterministically positioned semiconductor nanowires (NWs) is the basis of many devices for photonic, quantum, or conventional transistor applications. To explore and iterate on the design of larger circuits, the means to quickly place and electrically evaluate NWs at target locations must be developed. We propose and demonstrate a multi-NW circuit building concept on SiO2/Si

Simulating mismatch between calibration and target population in AI for mammography the retrospective VAIB study

AI cancer detection models require calibration to attain the desired balance between cancer detection rate (CDR) and false positive rate. In this study, we simulate the impact of six types of mismatches between the calibration population and the clinical target population, by creating purposefully non-representative datasets to calibrate AI for clinical settings. Mismatching the acquisition year b

Meta-analysis of uveal melanoma genome-wide association studies identifies novel risk loci and population effect size heterogeneity

Uveal melanoma (UM) is a rare but frequently metastasizing cancer. Genome-wide association studies have identified three common genome-wide significant germline risk loci. Here, we perform a genome-wide association study on 401 new cases and conduct a meta-analysis with three independent previously published cohorts for a total sample size of 2,426 cases. We confirm the three previously identified

Evaluation of timed dexamethasone eye drops to prevent proliferative retinopathy of prematurity : a study protocol for a randomized intervention, multi-centre, double-blinded trial (DROPROP)

Background: As the survival rate of preterm infants continues to rise worldwide, more infants are at risk of developing sight-threatening retinopathy of prematurity (ROP). Destructive retinal laser treatment and intravitreal injections of anti-vascular endothelial growth factor (VEGF), factor, which have potential systemic side effects, are necessary to prevent blindness in severe cases of ROP. Of

Platelet transfusion practice in the intensive care unit : the Nine-I international platelet transfusion survey

BACKGROUND: Platelet transfusions are frequent in the Intensive Care Unit (ICU), either as prophylaxis against bleeding complications or as treatment for bleeding. The European Society of Intensive Care Medicine guidelines for ICU patients generally recommend not using prophylactic platelet transfusions unless the platelet count falls below 10 × 10 9 cells/L in non-bleeding patients and make no re

Heterogeneity in ice sheets- vs. monsoon rainfall-induced silicate weathering from high to low latitudes

One of the most challenging problems in paleoclimate research is how orbital cyclicities forced Earth’s climate variations during the late Quaternary. To address this issue, we investigated the differences in silicate weathering, a sensitive climate indicator, at different latitudes on orbital timescales by examining geochemical and clay mineral data from the mid-latitude Sea of Okhotsk and integr

A non-genotoxic stem cell therapy boosts lymphopoiesis and averts age-related blood diseases in mice

Hematopoietic stem cell (HSC) transplantation offers a cure for a variety of blood disorders, predominantly affecting the elderly; however, its application, especially in this demographic, is limited by treatment toxicity. In response, we employ a murine transplantation model based on low-intensity conditioning protocols using antibody-mediated HSC depletion. While aging presents a significant bar

Angiotensin converting enzyme 2 in patients with sepsis associate with comorbidities but neither with mortality nor with organ failure

High levels of circulating angiotensin converting enzyme 2 (ACE2) are associated with several chronic diseases and mortality risk. Less is known about the prognostic value of ACE2 in patients with sepsis. In the present study, we aimed to investigate the association between plasma ACE2 levels on admission to the ED and 28-day mortality, organ failure, and level of care in a prospectively recruited

Röster från ett riskområde. En studie om synen på, tankarna om och upplevelsen av Södra Sofielund i ögonen på de som bor, som har bott och som är ideellt verksamma i området

This study aims to investigate how people who are living in, who have lived or who are currently working at a non-profit organization in Södra Sofielund in Malmö, Sweden, experience the area through different aspects such as feelings of safety and belonging. This study also aims to discover what resources they wish to see implemented in Södra Sofielund as well as to investigate what resources are

Twin pair analysis uncovers links between DNA methylation, mitochondrial DNA quantity and obesity

Alterations in mitochondrial metabolism in obesity may indicate disrupted communication between mitochondria and nucleus, and DNA methylation may influence this interplay. Here, we leverage data from the Finnish Twin Cohort study subcohort (n = 173; 86 full twin pairs, 1 singleton), including comprehensive measurements of obesity-related outcomes, mitochondrial DNA quantity and nuclear DNA methyla