The genomic inventory of a permafrost soil can be obtained through genomic characterization of the whole community (metagenomics) and/or an organism isolated from permafrost through culture or single-cell based methods. While there is often debate among the scientific community over whether genomic, transcriptomic, proteomic, or culture-based methods are best, the most promising current work combi

Mesenchymal stem cells (MSCs) have been studied for their potential benefits in treating acute respiratory distress syndrome (ARDS) and have reported mild effects when trialed within human clinical trials. MSCs have been investigated in preclinical models with efficacy when administered at the time of lung injury. Human integrin α10β1-selected adipose tissue-derived MSCs (integrin α10β1-MSCs) have

Aims: Estimation of prognosis in pulmonary arterial hypertension (PAH) has been influenced by that various risk stratification models use different numbers of prognostic parameters, as well as the lack of a comprehensive and time-saving risk assessment calculator. We therefore evaluated the various European Society of Cardiology (ESC)-/European Respiratory Society (ERS)-based three-and four-strata

AIMS: Heart failure (HF) is a frequent condition in the elderly, further complicated by associated pulmonary hypertension (PH), with impact on morbidity and mortality. Plasma proteins associated with cardiovascular disease, related to inflammation, neurohormonal changes, and myocyte stress, pathways recognized in the pathophysiology of HF, may provide information on disease severity and prognosis.

Introduction: Left heart failure (LHF) is commonly complicated by pulmonary hypertension (PH), increasing morbidity and mortality. The present study aimed to evaluate the prognostic value of inflammatory proteins in LHF with PH (LHF-PH). Materials and methods: The levels of 65 plasma proteins, analysed with proximity extension assay, were compared between healthy controls (n = 20), patients with L

This research report presents empirical findings from an ethnographic study of the role of informal social norms in reducing corruption in public and private schools in Hanoi. The study begins by building a theoretical framework that inculcates the significance of local informal social norms in analysing/understanding corruption and designing counteraction strategies, especially at the sub-nationa

Background and aimsPrior studies have suggested that the benefit from primary preventive defibrillator treatment for patients with non-ischemic cardiomyopathy primarily, treated with cardiac resynchronization therapy, may be age-dependent. We aimed to compare age-stratified mortality rates and mode of death in patients with non-ischemic cardiomyopathy who are treated with either primary preventive

Metal-halide perovskites (MHPs) are promising as active optoelectronic materials for a diverse range of devices. Anion exchange is a post-growth modification of MHP materials that allows tuning of the band gap and crystal structure by exposure to alternative halides, normally using solution methods. Here, low temperature gas-phase anion exchange for the conversion of CsPbBr3 nanowires (NW) into Cs

Vascular dysfunction is a hallmark of systemic inflammatory responses such as bacterial sepsis. The luminal surface of the blood vessels is coated with a dense layer of glycans and proteoglycans, collectively known as the glycocalyx. Surface associated glycoproteins of endothelial origin, or derived from pericytes, intravascular leukocytes, and plasma, are other important components of the glycoca

Most pathobionts of the respiratory tract form biofilms during asymptomatic colonization to survive and persist in this niche. Environmental changes of the host niche, often resulting from infection with respiratory viruses, changes of the microbiota composition, or other host assaults, can result in biofilm dispersion and spread of bacteria to other host niches, resulting in infections, such as o

Scientists have deemed existing protected areas in European forests insufficient to halt and reverse biodiversity loss resulting from ongoing intensification of management. In Sweden, protected areas are therefore complemented with the so-called areas of high conservation value (AHCVs), that is, landscapes encompassing both protected and assumed biodiversity-valuable areas as well as surrounding l

BACKGROUND: Cerebral palsy (CP) is an umbrella term where an injury to the immature brain affects muscle tone and motor control, posture, and at times, the ability to walk and stand. Orthoses can be used to improve or maintain function. Ankle-foot orthoses (AFOs) are the most frequently used orthoses in children with CP. However, how commonly AFOs are used by children and adolescents with CP is st

This paper proposes a ‘tool for thinking with’: that we can describe the interaction between people and computers, and especially people and developer tools, as a form of conversation. We outline this perspective, construct a work in progress analytical frame, and use it to talk about a couple of different examples and draw implications for future work.

Disinformation re-emerged in the 21st century as a public concern and professional challenge for actors seeking to navigate the new political and information landscape. This has led to a growing discussion among researchers on how disinformation relates to PD theory and practice. This chapter argues that disinformation comes with a set of opportunities for PD that open new perspectives to unresolv

Chemically sensitive diagnostics are indispensable to unravel reactive processes in combustion and beyond, to understand their development in time and space and to monitor the reaction progress under the conditions of interest. A multitude of techniques is available that may provide species composition together with other process-controlling variables as a function of the reaction environment. Ana