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Aim: MicroRNAs (miRNAs) regulate β-cell function, and β-cell mitochondria and insulin secretion are perturbed in diabetes. We aimed to identify key miRNAs regulating β-cell mitochondrial metabolism and novel β-cell miRNA-mitochondrial pathways. Methods: TargetScan (http://www.targetscan.org/) was used to predict if 16 miRNAs implicated in β-cell function target 27 cis-eGenes implicated in mitochon

Background and purpose: Recent progress in diagnostics and treatment of metastatic cancer patients have improved survival substantially. These developments also affect local therapies, with treatment aims shifting from short-term palliation to long-term symptom or disease control. There is consequently a need to better define the value of stereotactic body radiotherapy (SBRT) for the treatment of

Boreal forests play a crucial role in global carbon sequestration and storage, yet their vulnerability to climate change remains a significant concern. We present results from simulations with the process-based dynamic global vegetation model LPJ-GUESS of the combined effects of climate change and forest management on the carbon sink capacity of a boreal forest in southern Sweden. We compared two

Aim: To conduct the first revision of the World Health Organization International Classification of Functioning, Disability and Health (ICF) Core Sets for attention-deficit/hyperactivity disorder (ADHD). Method: A Delphi-like method was used, integrating evidence from stakeholder feedback and developing and piloting the ADHD ICF Core Set platform to inform revisions to the ADHD Core Sets. Results:

Previous research notes difficulties in functioning and low quality of life (QoL) among transition-age youth on the autism spectrum, and poor mental health may contribute to these difficulties. This study examined the role of autism symptom severity and mental health problems on self-reported functioning and QoL in treatment-seeking transition-age autistic youth. The study included 140 autistic yo

Chemical signals are known to influence interactions within and among species of aquatic organisms, including gastropods. However, despite the indispensable roles of chemical signals in species interactions, little is known about their effectiveness, especially in gastropods. The rapa whelk Rapana venosa (Valenciennes, 1846) is an ecologically and economically important gastropod, but it has also

Cerebrospinal fluid (CSF) biomarkers reflect brain pathophysiology and are used extensively in translational research as well as in clinical practice for diagnosis of neurological diseases, e.g., Alzheimer’s disease (AD). However, CSF biomarker concentrations may be influenced by non-disease related inter-individual variability. Here we use a data-driven approach to demonstrate the existence of in

INTRODUCTION: Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype. METHODS: Retrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial

Accelerated brain ageing has been observed in multiple psychiatric disorders. This study examined whether relationships between age and plasma neurofilament light (NfL) protein differed in individuals with psychiatric disorders (major depressive disorder (n = 42), bipolar affective disorder (n = 121), treatment-resistant schizophrenia (TRS, n = 82)) compared to two healthy control (HC) groups (n =

I denne bog forsøger forfatteren at afmontere de benspænd (krokben), som den svensktalende typisk oplever i mødet med dansktalende. Det drejer sig først og fremmest om den største sten i sprogforståelsen, nemlig den danske udtale, og den lidt mindre sten, det lumske ordforråd. Mange ord deler vi allerede, men der er også ord og vendinger, der komplicerer kommunikationen danskere og svenskere imell

Consumers’ ethical efforts are capped by unethical market forces. A longitudinal study of anti-consumers shows that when systemic support was removed, consumers previously fully committed to ethical lifestyles, exhibited symptoms of an ethical consumption gap, suggesting the problem lies not with the individual (gap) but with the context (cap).

Over-indebtedness—a situation in which individuals are unable to pay their expenses and debts get out of control—is increasing among young adults in Sweden, and predictions suggest that the problem will escalate after the COVID-19 pandemic. In this chapter we draw on our experience of initiating an ethnographic study of over-indebtedness among young adults during the COVID-19 pandemic, when opport

This technical report gives an overview of our submission to task 3 of the DCASE 2024 challenge. We present a sound event localization and detection (SELD) system using input features based on trainable neural generalized cross-correlations with phase transform (NGCC-PHAT). With these features together with spectrograms as input to a Transformer-based network, we achieve significant improvements o

Introduction: This article explores how sexuality is conceptualised and managed in a Spanish residential care unit for recently injured people. The institution operates under the banner of independent living, a key belief of the international disabled people’s movement, which champions self-determination, autonomy, and control over their support. Methods: A focused ethnography was conducted betwee

Functioning is a construct capturing how an individual’s engagement in everyday life emerges from the interaction between the individual and their environment. The World Health Organization’s International Classification of Functioning, Disability and Health (ICF) provides a biopsychosocial framework of functioning. Previously, the ICF was adapted for use in autism by developing Core Sets, a selec

PURPOSE: We investigated time trends of the obesity-mortality association, accounting for age, sex, and cause-specific deaths.METHODS: We analysed pooled nationwide data in Sweden for 3,472,310 individuals aged 17-39 years at baseline in 1963-2016. Cox regression and flexible parametric survival models investigated BMI-mortality associations in sub-groups of sex and baseline calendar years (men: <

PURPOSE: The Obesity and Disease Development Sweden (ODDS) study was designed to create a large cohort to study body mass index (BMI), waist circumference (WC) and changes in weight and WC, in relation to morbidity and mortality.PARTICIPANTS: ODDS includes 4 295 859 individuals, 2 165 048 men and 2 130 811 women, in Swedish cohorts and national registers with information on weight assessed once (2

Neuroblastoma is a childhood developmental cancer; however, its embryonic origins remain poorly understood. Moreover, in-depth studies of early tumor-driving events are limited because of the lack of appropriate models. Herein, we analyzed RNA sequencing data obtained from human neuroblastoma samples and found that loss of expression of trunk neural crest–enriched gene MOXD1 associates with advanc