Purification of biopharmaceuticals has shifted toward continuous and integrated processes, in turn bringing along a need for monitoring and control to maintain a desired separation between the target pharmaceutical and any impurities it may carry. In this study, a cycle-to-cycle control of the retention volumes of two compounds in a chromatographic, ion exchange purification step was developed, al

Kort efter att hon bevittnat den franska revolutionens fasor i Paris reste den engelska filosofen och feministen Mary Wollstonecraft till ett sömnigt Skandinavien. Kontrasterna kunde inte ha varit större. Ändå var det just i Sverige som hennes sista, stora politiska fråga väcktes: Hur förändrar man ett samhälle? Lena Halldenius följer Wollstonecraft på hennes sista filosofiska resa.Bildningsboxen

Background: The pathogenesis of appendicitis is not understood completely and establishing a correct diagnosis can be clinically challenging. Previous investigations have shown an association between a T helper cell (Th)2-mediated inflammatory response, for example immunoglobulin E (IgE)-mediated allergy, and a decreased risk of complicated appendicitis. The present study aimed to evaluate differe

The majority of studies on internal brand equity examine its various dimensions and relationships between them. While prior research specifies organizational practices relevant for successful internal branding, the insights about the impact of essential organizational factors on internal brand equity are still limited. This study focuses on organizational resilience that is vital for the existenceThe majority of studies on internal brand equity examine its various dimensions and relationships between them. While prior research specifes organizational practices relevant for successful internal branding, the insights about the impact of essential organizational factors on internal brand equity are still limited. This study focuses on organizational resilience that is vital for the existence

Winter warming events (WWE) are abrupt and short-lasting (hours-to-days) events of extraordinarily warm weather occurring during wintertime, sometimes accompanied by rainfall (rain on snow events; ROS). Through direct heat transfer and changes in the snowpack properties, these events cause changes in the below-ground thermal regime that, in turn, controls a suite of ecosystem processes ranging fro

Ambitiösa ideal om tvärvetenskap är välkänt svåra att omsätta i praktiken, delvis beroende på att de motarbetas av hur många universitet är strukturerade. Detta är ett problem för doktorander i tvärvetenskapliga projekt såväl som för deras handledare. Tvärvetenskapliga doktorander har precis som alla doktorander ett forskningsämne i vilket de förväntas utvecklas till självständiga forskare men ockAmbitious ideals about interdisciplinarity are notoriously difficult to put into practice, partly because they are counteracted by how many universities are organised. This is a problem for doctoral students in interdisciplinary projects as well as for their supervisors. Interdisciplinary doctoral students, like all doctoral students, have a research subject in which they are expected to develop i

The theoretical foundation of inflation targeting was laid out by the Swedish economist Knut Wicksell (1851-1926) in his groundbreaking treatise, Interest and Prices, published originally in German in 1898. Here he proposed price stability as the rule for monetary policy. Today, inflation targeting is considered the best-practice approach to monetary policy across the world. It has contributed to

A piece about a just transition to a low-carbon future (contribution to UNESCO Inclusive Policy Lab 'Think pieces' that explores emerging issues in inclusive policies as well as offering cutting edge solutions).

The app-based COVID Symptom Study was launched in Sweden in April 2020 to contribute to real-time COVID-19 surveillance. We enrolled 143,531 study participants (≥18 years) who contributed 10.6 million daily symptom reports between April 29, 2020 and February 10, 2021. Here, we include data from 19,161 self-reported PCR tests to create a symptom-based model to estimate the individual probability of

Cerebral oedema develops after anoxic brain injury. In two models of asphyxial and asystolic cardiac arrest without resuscitation, we found that oedema develops shortly after anoxia secondary to terminal depolarizations and the abnormal entry of CSF. Oedema severity correlated with the availability of CSF with the age-dependent increase in CSF volume worsening the severity of oedema. Oedema was id

One of the key implications of COVID-19 is the adoption of physical distancing provisions to minimise the risk of virus transmission. Physical distancing can have significant consequences on crowd movement both in normal conditions and during emergencies. The impact of physical distancing is discussed in this chapter by first presenting an overview of its implications on crowd dynamics and space u

Electrification of commercial heavy vehicles has led to the offer of different electric drive-based powertrain architectures, most of them with the adaptation of the diesel engine based architecture. Due to the limited driving range possible, optimal configuration of the powertrain becomes a vital task with the battery as the energy source, which also takes a significant portion of payload capacit

ABO3 perovskites display a wide range of phase transitions, which are driven by A/B-site centered polyhedral distortions and/or BO6 octahedral tilting. Since heterogeneous substitutions at the A/B-site can locally alter both polyhedral distortions and/or tilting, they are often used to create phase boundary regions in solid solutions of ABO3, where the functional properties are highly enhanced. Ho

Background: There is an urgent need for effective treatments against glioblastoma (GBM). In this trial, we investigated the efficacy and safety of an adoptive cell-based immunotherapy. Methods: Patients with newly diagnosed GBM were recruited at 4 study sites in Sweden. The patients were randomized 1:2 to receive either radiotherapy (RT), 60 Gy/30 fractions, with concomitant and adjuvant temozolom

Background: Targeted therapeutic mild hypercapnia may attenuate brain injury in comatose adults resuscitated from out-of-hospital cardiac arrest. Objective: To describe the study protocol and statistical analysis plan for the Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) trial. Design, setting, participants and interventions: TAME is a phase 3, multicentre, paralle

Based on the critical velocity model, impact and capture efficiencies in an AGTB turbine cascade are investigated numerically under various inlet angles of mainstream, blowing ratios, particle sizes, and particle densities. The effect of hole configuration on deposition is analyzed based on comparisons of results from combined hole and cylindrical hole. The impact efficiency increases with the inc

This paper presents a detailed sedimentologic data set of minor moraines (heights ≤2.0 m, widths ≤14 m, lengths ≤108 m) that formed beginning near the end of the Little Ice Age by Schwarzensteinkees, a valley glacier in Austria. Sorted sediment and stratified diamict dominate five exposures, and compact massive diamict exists in one exposure. This sediment is interpreted as proglacial outwash and

Gender, being an identity contingency as coined by Claude M. Steele in his book Whistling Vivaldi, is not self-chosen, is virtually impossible to escape, and comes with expectations, prejudice and – most importantly – uneven pre-conditions for our choices in life. Gender inequality is a wide-spread problem, causing much harm on theindividual and societal levels, and the academic world is no exempt