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Allosteric communication within proteins is a hallmark of biochemical signaling, but the dynamic transmission pathways remain poorly characterized. We combined NMR spectroscopy and surface plasmon resonance to reveal these pathways and quantify their energetics in the glucocorticoid receptor, a transcriptional regulator controlling development, metabolism, and immune response. Our results delineat

In contrast to what is observed in aerobic uplands, microbial biomass and the presence of electron acceptors, such as iron oxides, play a crucial role in regulating soil organic C (SOC) mineralisation in paddy soils. However, the related underlying mechanisms are still poorly explored. We conducted an anaerobic incubation study to investigate changes in CO2 emissions from SOC and acetate (13C-labe

The water sector in Somalia is fragmented and needs coordination to establish a functioning water governance system. Therefore, commitments from all affected stakeholders are needed to support water resources development in Somalia. This paper proposed a water compact for Somalia that can address all water sector challenges to approach sustainability. The paper starts by analyzing water sector sta

Septic shock, a serious consequence of disseminated infection that has a high mortality, is due to a dysregulated, severe immune response triggered by the infection. Acute phase reactants play key roles in sepsis, for example, hepcidin regulating iron metabolism. Reticulocyte haemoglobin (Ret-He) depends on available iron in blood, indirectly regulated by hepcidin. This study aimed at exploring ra

The association between breast cancer risk defined by the Tyrer-Cuzick score (TC) and disease prognosis is not well established. Here, we investigated the relationship between 5-year TC and disease aggressiveness and then characterized underlying molecular processes. In a case-only study (n = 2474), we studied the association of TC with molecular subtypes and tumor characteristics. In a subset of

Purpose: Healthy spinal balance is dependent on spinal sagittal alignment. It is evaluated by several spinopelvic measures. The objective of this study is to investigate the effect of age and body mass index and the bone mineral density on the several vertebral measures and sagittal spinopelvic measurements. Methods: In this cross-sectional study, a total of 89 female patients were grouped accordi

The catalytic oxidation of CO on transition metals, such as Pt, is commonly viewed as a sharp transition from the CO-inhibited surface to the active metal, covered with O. However, we find that minor amounts of O are present in the CO-poisoned layer that explain why, surprisingly, CO desorbs at stepped and flat Pt crystal planes at once, regardless of the reaction conditions. Using near-ambient pr

Two of Cassian’s works, the Institutiones and the Collationes, are preserved in both Latin and Greek, and almost all scholars have taken it for granted that he wrote exclusively in Latin. This paper examines two passages from Cassian’s writings, one from the Institutiones (which has a parallel in an Evagrian florilegium) and the other from the Collationes. Arguing against the prevailing view, the Two of Cassian’s works, the Institutiones and the Collationes, are preserved in both Latin and Greek, and almost all scholars have taken it for granted that he wrote exclusively in Latin. This paper examines two passages from Cassian’s writings, one from the Institutiones (which has a parallel in an Evagrian florilegium) and the other from the Collationes. Arguing against the prevailing view, the

The natural organic matter (NOM) and color content of surface waters are increasingly becoming an issue for artificial groundwater recharge plants. Water from Lake Bolmen, in southern Sweden, had in 2017 an annual average NOM and color content of 8.6 mg/L total organic carbon (TOC) and 57 mg Pt/L respectively, and values ranging from 7.8 to 9.6 mg/L TOC and 50-70 mg Pt/L. Since water from Lake Bol

Low rank approximation is a commonly occurring problem in many computer vision and machine learning applications. There are two common ways of optimizing the resulting models. Either the set of matrices with a given rank can be explicitly parametrized using a bilinear factorization, or low rank can be implicitly enforced using regularization terms penalizing non-zero singular values. While the for

The damping ratio is a key performance measure in systems that can be modelled as networks of masses and springs. We derive a lower bound on this quantity that applies to such networks when the masses are subject to viscous damping. The result allows the size of the damping ratio to be understood as a function of the system parameters. We use this to derive a decentralised criterion which, if sati

Spins in solids are an ideal candidate to act as a memory and interface with superconducting qubits due to their long coherence times. We spectroscopically investigate erbium-167-doped yttrium orthosilicate as a possible microwave-addressed memory employing its microwave frequency transitions that occur without applying an external magnetic field. We obtain coherence times of 380 ?s in a ground st

Large igneous provinces and associated silicic magmatism can have a significant global climatic effect, so we explored the relationship between the large igneous province record and the ca. 580 Ma Gaskiers glaciation. The late Ediacaran glaciation exists on at least 14 different paleocontinental blocks, and assuming synchroneity, this Gaskiers glaciation was likely of short duration, with estimate

An efficient synthetic route to the mono-endo-6- and bis-endo,endo-6,12-N,N-diethylcarbamoyl derivatives of Tröger’s base (TB), endo-7 and endo-8, is reported. Studies of reaction time, proton source, and additive allowed establishment of optimized conditions for the conversion of exo-7 into the corresponding isomer endo-7. With a longer reaction time, the exo,exo-6,12 bis-carbamoyl derivative exo

Iridium(iii) half-sandwich complexes containing 7-chloroquinoline-1,2,3-triazole hybrid ligands were synthesised and their inhibitory activities evaluated against the Plasmodium falciparum malaria parasite. Supporting computational analysis revealed that metal coordination to the quinoline nitrogen occurs first, forming a kinetic product that, upon heating over time, forms a more stable cyclometal

Purpose: Onyx® embolization causes severe artifacts on subsequent CT-examinations, thereby seriously limiting the diagnostic quality. The purpose of this work was to compare the diagnostic quality of the tailored metal artifact reducing algorithms iMAR to standard reconstructions of CTA in patients treated with Onyx® embolization. Method: Twelve consecutive patients examined with Dual Energy CTA a

Objectives: To evaluate the potential of artificial intelligence (AI) to identify normal mammograms in a screening population. Methods: In this retrospective study, 9581 double-read mammography screening exams including 68 screen-detected cancers and 187 false positives, a subcohort of the prospective population-based Malmö Breast Tomosynthesis Screening Trial, were analysed with a deep learning–b