Flertalet nya läkemedel tas fram av universitet och undervisningssjukhus, ofta med betydande offentliga subsidier, för att därefter tas över av läkemedelsindustrin, vars främsta uppgift är att utföra de kliniska prövningarna. Det är viktigt nog, men betydligt mindre innovativt än vad industrin vill få oss att tro, skriver Anders Jeppsson i polemik mot ett tidigare inlägg av Pierre Lafolie.

The difference in length of breast feeding between women with a BRCA 1 mutation and their unaffected relatives was investigated. Fifty women belonging to a family with a known BRCA1 mutation had themselves undergone testing and each had given birth to at least one child. Women with BRCA1 mutation breast-fed their first infant for a significantly shorter period (P = 0.048) and the second and third

Introduction: We investigated whether there were any differences in the frequency and severity of pin site infections by performing pin site care daily or once a week. We studied patients operated on for gonarthrosis by the hemicallotasis technique, using hydroxyapatite-coated pins in the metaphyseal bone and standard pins in the diaphyseal bone. Patients and methods: 50 patients were prospectivel

Spatially and spectrally resolved cathodoluminescence in the scanning electron microscope is a very powerful technique for studying the optical properties of semiconductor structures, especially low-dimensional structures (structures with nanometre-sized features). The technique is generally nondestructive and can be combined with the normal imaging capabilities and analysis possibilities of the s

Objective.. To describe the diversity in dietary patterns existing across centres/regions participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). Design and setting.. Single 24-hour dietary recall measurements were obtained by means of standardised face-to-face interviews using the EPIC-SOFT software. These have been used to present a graphic multi-dimensional com

Aims: Objectives were (a) to estimate healthcare cost and productivity losses due to smoking in Sweden 2001 and (b) to compare the results with studies for Sweden 1980, Canada 1991, Germany 1996, and the USA 1998. Methods: Published estimates on relative risks and Swedish smoking patterns were used to calculate attributable risks for smokers and former smokers. These were applied to cost estimates

The purpose of the present study was to develop a new model of the initial part of an evacuation process, i.e., the pre-movement phase. A new method for estimating the pre-movement time was also going to be proposed. In the initial part of the study an inventory of existing models of human behaviour during fire evacuation was performed. This was followed by a literature review about helping behavi

The COST/IWA benchmark simulation model has been available for seven years. Its primary purpose has been to create a platform for control strategy benchmarking of activated sludge processes. The fact that the benchmark has resulted in more than 100 publications, not only in Europe but also worldwide, demonstrates the interest in such a tool within the research community In this paper, an extension

Increased production of reactive oxygen species (ROS) has been suggested as a cause of diabetic complications. Uncoupling proteins (UCPs) have been ascribed a role in reducing the formation of ROS, and genetic variation in genes encoding for UCPs could thus be putative candidate genes for diabetic nephropathy. To test this hypothesis we searched for association between the A→G (−3862) variant in U

Objective To determine the effect of ONO-8815Ly on uterine contractions. Design A randomised, double-blind, placebo-controlled, dose-ascending, cross-over study. Setting Department of Obstetrics and Gynaecology, University Hospital of Lund, Sweden. Population Seventeen, healthy, parous and permanently sterilised women. Methods Intrauterine pressure was recorded on days 1-3 of bleeding of two m

Correlations between p and (p) over bar at transverse momenta typical of enhanced baryon production in Au + Au collisions are reported. The PHENIX experiment has measured same and opposite sign baryon pairs in Au + Au collisions at root s(NN) = 200 GeV. Correlated production of p and p with the trigger particle from the range 2.5 < p(T) < 4.0 GeV/c and the associated particle with 1.8 < p(T) < 2.5

Recent experimental findings and theoretical approaches to the electric dipole (El) strength distribution below the particle emission threshold at shell closures are revisited. Results from photon scattering experiments are discussed and compared to predictions within the quasiparticle-phonon nuclear model. An analysis of the fine structure of the El strength is presented. Recent studies of the E1

A laboratory experiment was performed to estimate the elemental composition of rhizomorphs of an ectomycorrhizal (EM) fungus growing in a patchy environment. Successive samples of Rhizopogon rhizomorphs, located adjacent to patches with organic matter or patches with acid-washed sand, were taken over a period of 45 d. The mass per unit area was analyzed with scanning transmission ion microscopy (S