Apolipoprotein A-I (apoA-I) is the main protein involved in the formation of high-density lipoprotein (HDL), it is the principal mediator of the reverse cholesterol transfer (RCT) pathway and provides cardio-protection. In addition to functional wild-type apoA-I, several variants have been shown to associate with hereditary amyloidosis. In this study we have performed biophysical and biochemical a

This paper analyses data on occupants׳ movement on stair landings collected during an evacuation drill performed in a six-storey office building in the United States. A total of 215 occupant travel path trajectories were filmed and time on the stair landings and egress behaviours were analysed. Data were analysed using a probabilistic approach, i.e., the probability of different occupant travel pa

Väl fungerande bytespunkter är viktiga för kollektivtrafikens konkurrenskraft. Själva bytet, som är en del av varje resa, kan upplevas som en stor del av reskedjan, varför det är viktigt att bytestiden minimeras men även att bytespunkten erbjuder så hög komfort- och servicenivå som möjligt. Våra kunskaper om vilka kvaliteter som är viktiga i bytespunkter samt hur viktiga dessa är i förhållande til

Internationally comparable quality assurance of Human Papillomavirus (HPV) DNA detection and typing methods is essential for evaluation of HPV vaccines and effective monitoring and implementation of HPV vaccination programs. Therefore, the World Health Organisation (WHO) HPV Laboratory Network (LabNet) designed an international proficiency study. Following announcement at the WHO website, respondi

There are two theories that attempt to explain how attention is deployed when lines are traced. Initially, it was believed that a covert zoom lens moved along the line. Recent evidence has, however, suggested that attention spreads along the line, rather than moving along it, perhaps as part of an effortful object-parsing process. Three experiments tested the spreading and moving accounts of line

This study describes for the first time the expression levels of genes encoding membrane transporters and drug-metabolizing enzymes in the lungs of ex-smoking patients with chronic obstructive pulmonary disease (COPD). Membrane transporters and drug-metabolizing enzymes are key determinants of drug uptake, metabolism, and elimination for systemically administered as well as inhaled drugs, with con

The Centre party weathered what amounted to an almost existential mid-term public opinion crisis, to end up outperforming its coalition partners in the 2014 general election. Although it too fell back, it shed a notable proportion of tactical support voters, and actually increased its share of genuine, first-preference, voters. The Centre party has revisited and refreshed its ideological foundatio

In vivo gene transfer using viral vectors is an emerging therapy for neurodegenerative diseases with a clinical impact recently demonstrated in Parkinson's disease patients. Recombinant adeno-associated viral (rAAV) vectors, in particular, provide an excellent tool for long-term expression of therapeutic genes in the brain. Here we used the [C-11] raclopride [(S)-(-)-3,5-dichloro-N-((1-ethyl-2-pyr

Purpose: To investigate the characteristics and change in use among very old Swedish users and non-users of assistive devices (ADs) for mobility and personal care, over a six-year period, and to investigate factors predicting AD use over a six-year period. Method: Descriptive statistics and logistic regression were used to analyse quantitative data from a subsample from the Swedish part of the

The introduction, establishment and spread of alien species is a major threat to biodiversity and the provision of ecosystem services for human wellbeing. In order to reduce further loss of biodiversity and maintain productive and sustainable ecosystems, understanding the ecological mechanisms underlying species invasions and avoiding potentially harmful effects on native communities is urgently n

Studies to date on ferromagnet/d-wave superconductor heterostructures focus mainly on the effects at or near the interfaces while the response of bulk properties to heterostructuring is overlooked. Here we use resonant soft x-ray scattering spectroscopy to reveal a novel c-axis ferromagnetic coupling between the in-plane Cu spins in YBa2Cu3O7-x (YBCO) superconductor when it is grown on top of ferr

We demonstrate InGaAs multigate MOSFETs, so-called FinFETs. The lateral nanowires constituting the channel in these devices have been formed using selective area regrowth, where the surfaces of the nanowires are crystallographic planes. L-g = 32 nm devices exhibit peak transconductance of 1.8 mS/mu m at V-ds = 0.5 V. We also report on RF characterization of these devices. A small-signal hybrid-p m

The aim of this thesis was to analyze the genetic and epigenetic characteristics of pediatric high hyperdiploid acute lymphoblastic leukemia (HeH ALL), the most common type of childhood malignancy. The three original articles presented in this thesis have addressed three major questions regarding HeH ALL: what are the genetic characteristics of the most common structural abnormality – dup(1q)? Are

Previous research has shown a male bias in the media. This study tests this statement by examining how the pronouns She and He are used in a news media context. More specifically, the study tests whether He occurs more often and in more positive semantic contexts than She, as well as whether She is associated with more stereotypically and essential labels than He is. Latent semantic analysis (LSA)

We have temporally characterized, dispersion compensated and carrier-envelope phase stabilized 1.4-cycle pulses (3.2 fs) with 160 mu J of energy at 722 nm using a minimal and convenient dispersion-scan setup. The setup is all inline, does not require interferometric beamsplitting, and uses components available in most laser laboratories. Broadband minimization of third-order dispersion using propa

The fragmentation of a 550MeV/u primary beam of Ni-58 on a Be-9 target has been used to measure time-and energy-correlated gamma decays following the implantation of event-by-event discriminated secondary fragments into a Be-9 stopper plate. A new isomeric gamma decay with T-1/2 = 14(6 4) ns and E-gamma = 646.2(2) keV is observed and attributed to the decay of the yrast 3/2-state in Co-53(27)26. T

Elastic scattering of photons from C-12 has been investigated using quasimonoenergetic tagged photons with energies in the range 65-115 MeV at laboratory angles of 60 degrees, 120 degrees, and 150 degrees. at the Tagged-Photon Facility at the MAX IV Laboratory in Lund, Sweden. A phenomenological model was employed to provide an estimate of the sensitivity of the C-12(gamma,gamma)C-12 cross section

Zircon in five samples of variably comminuted, melted, and hydrothermally altered orthogneiss from the Maniitsoq structure of southern West Greenland yield a weighted mean 207Pb/206Pb age of 3000.9 +/- 1.9Ma (ion probe data, n=37). The age data constitute a rare example of pervasive and nearly complete isotopic resetting of zircon during a regional hydrothermal event. Many zircon grains are homoge

Background: Primary intracardiac tumours are rare, there are however several entities that can mimic tumours. Contrast echocardiography has been suggested to aid the differentiation of various suspected masses. We present a case where transthoracic echocardiography completely misdiagnosed a left atrial mass, partly due to use of echo contrast. Case presentation: An 80 year-old woman was referred f