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Background: Particle exposure is a risk factor for cardiovascular diseases. Mitochondrial DNA (mtDNA) is a primary target for oxidative stress generated by particle exposure. We aimed to elucidate the effects of occupational exposure to particle-containing welding fumes on different biomarkers of mtDNA function, and in turn, explore if they modify the association between particle exposure and card
Background: Intracerebral transplantation of human induced pluripotent stem cells (iPSCs) can ameliorate behavioral deficits in animal models of stroke. How the ischemic lesion affects the survival of the transplanted cells, their proliferation, migration, differentiation, and function is only partly understood. Methods: Here we have assessed the influence of the stroke-induced injury on grafts of
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess and compare the effects and complication rates of licensed bioengineered nerve conduits or wraps for surgical repair of traumatic peripheral nerve injuries of the upper limb. To compare effects and complications against the current gold surgical standard (nerve autograft).
In this paper the mechanical response of single-crystal nano-sized Cu beams of different sizes, loaded in displacement controlled tension under constant strain rate is investigated through 3D molecular dynamic simulations using the free-ware LAMMPS. The effects from pure geometric scaling are determined for two different crystallographic orientations of the lattice. Stress-strain curves were recor
For the International Large Detector concept at the planned International Linear Collider, the use of time projection chambers (TPC) with micro-pattern gas detector readout as the main tracking detector is investigated. In this paper, results from a prototype TPC, placed in a 1. T solenoidal field and read out with three independent Gas Electron Multiplier (GEM) based readout modules, are reported
An increase of the magnetic moment in superconductor/ferromagnet (S/F) bilayers V(40 nm)/F (, Co(3 nm), Ni(3 nm)) was observed using SQUID magnetometry upon cooling below the superconducting transition temperature T C in magnetic fields of 10 Oe to 50 Oe applied parallel to the sample surface. A similar increase, often called the paramagnetic Meissner effect (PME), was observed before in various s
Distributed computing infrastructures have a long history, starting with pools of PCs and clusters three decades ago, briefly passing a stage of HPC Grids, and now converging to fully virtualised facilities. The Nordic Tier-1, prototype of which was launched back in 2003 to serve CERN needs, is a small-scale model of a distributed infrastructure, and thus an interesting case for studying experienc
This article analyses the selection of person reference expressions in narratives in Umpila/Kuuku Ya'u, a Pama-Nyungan language of Cape York Peninsula (Australia). The analysis takes the principle of topic-fittedness, one of a set of design principles proposed to account for the interactional conditioning of person reference formulation, and applies it to Umpila/Kuuku Ya'u narration. The ensuing a
Background: Smoking is reported to affect the risk of a number of chronic disorders, including rheumatic diseases. Previous cross-sectional studies have shown a lower frequency of smoking in patients with primary Sjögren's syndrome (pSS). The aim of this study was to investigate the impact of smoking and socioeconomic status on the risk of subsequent diagnosis of pSS in a nested case-control study
Objective: To determine if blood neurofilament light chain (NfL) protein can discriminate between Parkinson disease (PD) and atypical parkinsonian disorders (APD) with equally high diagnostic accuracy as CSF NfL, and can therefore improve the diagnostic workup of parkinsonian disorders. Methods: The study included 3 independent prospective cohorts: the Lund (n = 278) and London (n = 117) cohorts,
It is generally accepted that China will be a great competitor to the Western industrialized countries in the twenty-first century. Is this a reasonable opinion? Is it true that China’s size and growth rate are important in measuring its potential as a competitor? Two questions should be considered. First, is the growth rate of the Chinese economy based on productivity gains? If economic growth is
Stars in open clusters are expected to share an identical abundance pattern. Establishing the level of chemical homogeneity in a given open cluster deserves further study as it is the basis of the concept of chemical tagging to unravel the history of theMilkyWay.M67 is particularly interesting given its solar metallicity and age as well as being a dense cluster environment.We conducted a strictly
Simulation results for future measurements of electromagnetic proton form factors at P ¯ ANDA (FAIR) within the PandaRoot software framework are reported. The statistical precision with which the proton form factors can be determined is estimated. The signal channel p¯ p→ e+e- is studied on the basis of two different but consistent procedures. The suppression of the main background channel, i.e.p¯
In 2014 a small fire started in a forest in central Sweden. Within a few days it developed into the largest wildfire in Sweden in the last 50 years. As the scale of the fire increased, so did the need for direction and coordination of the resources engaged in the response operation. Both official investigators and the research community have studied the challenges and come up with recommendations
The Fourier dimension is not, in general, stable under finite unions of sets. Moreover, the stability of the Fourier dimension on particular pairs of sets is independent from the stability of the compact Fourier dimension.
These European Board of Anaesthesiology (EBA) recommendations for safe medication practice replace the first edition of the EBA recommendations published in 2011. They were updated because evidence from critical incident reporting systems continues to show that medication errors remain a major safety issue in anaesthesia, intensive care, emergency medicine and pain medicine, and there is an ongoin
Introduction: We aimed to determine the added value of cerebrospinal fluid (CSF) to clinical and imaging tests to predict progression from mild cognitive impairment (MCI) to any type of dementia. Methods: The risk of progression to dementia was estimated using two logistic regression models based on 250 MCI participants: the first included standard clinical measures (demographic, clinical, and ima
III-V compound semiconductors are used in, among many other things, high-frequency electronics. They are also considered as a replacement for silicon in CMOS technology. Yet, a III-V transistor outperforming state-of-the-art silicon devices in VLSI-relevant metrics has not yet decisively been demonstrated. In this work, the limits of III-V FET performance, for both RF and VLSI applications, are ex
In humans, the non-gastric H+/K+ ATPase (ATP1AL1) has previously been shown to be expressed in the epithelia of skin, kidney and colon. In this study we tested the hypothesis that the non-gastric H+/K+ ATPase is localized to the syncytiotrophoblast, the transporting epithelium of the human placenta. Microvillous (MVM) and basal plasma membranes (BM) of the syncytiotrophoblast were isolated from te
