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Background: Childhood cancer survivors (CCS) are at an increased risk for cardiovascular diseases (CVD). It was the primary aim of this study to determine different measures of cardiac, carotid, lipid, and apolipoprotein status in young adult CCS and in healthy controls. Methods: Cardiac and common carotid artery (CCA) structure and function were measured by ultrasonography. Lipids and apolipoprot
I sitt tidiga verk Om empatins problem (Zum Problem der Einfühlung) försöker Edith Stein ”specificera empatins speciellt intentionella karaktär” (Zahavi 2001,158). Ett övergripande mål för Stein är att finna de element som konstituerar en individ som en ”annan” för oss. Ett liknande syfte återfinns i skrifter som koncipierades delvis under samma tid på ett annat kunskapsområde, skådespelarkonstensIn her early work On the problem of empathy, (Zum Problem der Einfühlung), Edith Stein attempts to ´specify the particular intentional character of empathy´ (Zahavi 2001, 158). An overall aim for Stein is to find out the elements of what constitutes an individual as an ´other´ for us. A similar aim is present in writings that were conceived partly at the same time within another field of knowledge
One of the challenges of genetic testing in patients with hemophilia A is the interpretation of sequence variants. Here we report a silent variant found in exon 2 in the F8 gene in a 47-year-old patient with a previous von Willebrand disease (VWD) type 1 diagnosis. Clinically he had mild bleeding symptoms restricted to prolonged bleeding from minor wounds. Sanger sequencing of F8 gene using genomi
Support for developing a work identity hasbeen shown to be essential for the recovery process ofyoung adults with mental health problems. Sinceresearch shows that the development of a student roleduring the educational years for these young adultsmay be interrupted, this time period may be relevant toexplore in order to support career development and thecritical transition to adulthood for this ta
The current threats of climate change connected to the unsustainable consumption of fossil resources paired with an increasing world population demands the exploration of alternative raw materials for the production of food, fuel and specialty chemicals. Agricultural waste streams present suitable sources due to their availability in large quantities at low costs without competing with current foo
Heparin-binding protein (HBP) is a promising biomarker for the development and severity of sepsis. To guide its use, it is important to understand the factors that could lead to false-positive or negative results, such as inappropriate release and inadequate clearance of HBP. HBP is presumably released only by neutrophils, and the organs responsible for its elimination are unknown. In this study,
BACKGROUND: The mechanisms of association between diabetes and inner ear dysfunction are unknown, although endolymphatic hydrops may be involved. We have previously shown that insulin signaling components are expressed in human saccule and that insulin signaling takes place in HEI-OC1 auditory cells.AIM: To explore Nedd4-2 as a target for insulin signaling.MATERIALS AND METHODS: Effects of insulin
Electromagnetic form factors serve to explore the intrinsic structure of nucleons and their strangeness partners. For the decay S0 ? ?e+e-, due to limited phase space, the effects caused by the Sigma-to-Lambda transition form factors compete with the QED radiative corrections. These corrections are addressed in the present work, evaluated beyond the soft-photon approximation, i.e., over the whole
Within the Standard Model Effective Field Theory framework, with operators up to dimension 6, we perform a model-independent analysis of the lepton-flavour-violating processes involving tau leptons. Namely, we study hadronic tau decays and l-t conversion in nuclei (l = e, µ). Based on available experimental limits, we establish constraints on the Wilson coefficients of the operators contributing t
T. Larspers har presenterat en väl genomarbetad presentation utifrån flera aspekter av det kristna livet kring Siljansbygden vid sekelskiftet 1800-1900. Han har visat att lokalhistoria inte bara handlar om beskrivningar av det lokala utan är både informationsberikande och har en förklaringspotential som förutsätter både resultat från kvalificerad forskning och fördjupande reflektion.
Molekylär kunskap om tumörutveckling leder till allt fler målinriktade cancerbehandlingar.Heltäckande molekylär tumörkarakterisering ger möjlighet att undersöka samtliga behandlingsalternativ med en analys.Arbetsutskottet för solida tumörer inom Genomic Medicine Sweden samarbetar för att etablera regional och nationell infrastruktur för storskalig tumörsekvensering och kopplad dataanalys i sjukvårRapidly expanding knowledge of the molecular landscape of cancers has resulted in the implementation of an increasing number of specific therapies targeted at tumors with specific molecular aberrations. In response to this development, new tools for predictive testing for molecular targets need to be implemented in routine health care. To achieve robust future molecular diagnostic pathology, and e
