Background: Tumour necrosis factor (TNF) antagonists have proved effective as treatment against rheumatoid arthritis ( RA), but the unresolved issue of whether the use of anti-TNF therapy increases the already elevated risk of lymphoma in RA remains a concern. Methods: Using the Swedish Biologics Register (ARTIS), the Swedish Cancer Register, pre-existing RA cohorts and cross-linkage with other na

Many studies have been made on the impact of supplemental instruction in supported courses, most show significantly better examination results for students attending supplemental instruction in comparison to those who do not. However, remarkably little attention has been devoted to following up whether the benefits of supplemental instruction reach beyond the course it supports. The present study

Background The Chemotaxis inhibitory protein of Staphylococcus aureus (CHIPS) blocks the Complement fragment C5a receptor (C5aR) and formylated peptide receptor (FPR) and is thereby a potent inhibitor of neutrophil chemotaxis and activation of inflammatory responses. The majority of the healthy human population has antibodies against CHIPS that have been shown to interfere with its function in vit

Purpose: Yttrium-90 (Y-90) is one of the most commonly used radionuclides in targeted radionuclide therapy (TRT). Since it decays with essentially no gamma photon emissions, surrogate radionuclides (e.g., In-111) or imaging agents (e.g., Tc-99m MAA) are typically used for treatment planning. It would, however, be useful to image Y-90 directly in order to confirm that the distributions measured wit

Three studies of the psychological and physiological effects on people of colored room interiors are described. Experiment 1 compared a colorful and a gray room, whereas in experiments 2 and 3 red and blue rooms were compared. The results indicate that the color of an interior space will have effects on many different levels. The perception of the room itself was affected, and the colors also had

When demand is uncertain, manufacturers and retailers often have private information on future demand, and such information asymmetry impacts strategic interaction in distribution channels. In this paper, we investigate a channel consisting of a manufacturer and a downstream retailer facing a product market characterized by short product life, uncertain demand, and price rigidity. Assuming the fir

Background: Although case-control studies have identified numerous single nucleotide polymorphisms (SNPs) associated with prostate cancer, the clinical role of these SNPs remains unclear. Objective: Evaluate previously identified SNPs for association with prostate cancer and accuracy in predicting prostate cancer in a large prospective population-based cohort of unscreened men. Design, setting, an

Background: Dietary supplement use is increasing, but there are few comparable data on supplement intakes and how they affect the nutrition and health of European consumers. The aim of this study was to describe the use of dietary supplements in subsamples of the 10 countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Specific questions on di

The electronic structure of methylene peroxide is a balance between zwitterionic and biradical valence structures. In this work we study how this balance is changed by an aqueous solvent, and what effect this has on the nuclear structure. A combined quantum chemical statistical mechanical method with an explicit representation of the solvent is used. The multiconfigurational quantum chemical metho

This paper draws upon the recent carbon market turmoil to understand how the private realm is imagined in global climate governance. Instead of asking which entities (eg, public or private authorities) govern the carbon economy, we draw attention to the procedures (eg, caps on emissions, techniques of verification, or performance standards) by which carbon markets are made thinkable and governable

For some time it has been argued that cities all over the world have become more entrepreneurial and increasingly competitive. Most research has focused on spectacular events in well-known metropolises, but far less is known about how smaller cities engage in competitive activities. This paper focuses on how, why and what Swedish cities hope to achieve by engaging themselves in hosting the tryouts

In this study, a signal analysis framework based on the Karhunen-Loève expansion and k-means clustering algorithm is proposed for the characterisation of arteriovenous (AV) fistula’s sound recordings. The Karhunen-Loève (KL) coefficients corresponding to the directions of maximum variance were used as classification features, which were clustered applying k-means algorithm. The results showed that

Abstract in UndeterminedFaster-than-Nyquist (FTN) signaling is a method of improving bandwidth efficiency by transmitting information beyond Nyquist's orthogonality limit for interference free transmission. Previously have theoretically established that FTN can provide improved bandwidth efficiency. However, this comes at the cost of higher decoding complexity at the receiver. Our work has evaluat

The inclusive photoproduction of D* mesons and of D*-tagged dijets is investigated with the H1 detector at the ep collider HERA. The kinematic region covers small photon virtualities Q(2) < 2 GeV2 and photon-proton centre-of-mass energies of 100< W-gamma p < 285 GeV. Inclusive D* meson differential cross sections are measured for central rapidities vertical bar eta(D*)vertical bar < 1.5 and transv

Purpose: To assess whether grating-based X-ray dark-field imaging can increase the sensitivity of X-ray projection images in the diagnosis of pulmonary emphysema and allow for a more accurate assessment of emphysema distribution. Materials and Methods: Lungs from three mice with pulmonary emphysema and three healthy mice were imaged ex vivo using a laser-driven compact synchrotron X-ray source. Me

Radial velocities measured from near-infrared (NIR) spectra are a potentially powerful tool to search for planets around cool stars and sub-stellar objects. However, no technique currently exists that yields NIR radial velocity precision comparable to that routinely obtained in the visible. We are carrying out an NIR radial velocity planet search program targeting a sample of the lowest-mass M dwa