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Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence : analysis within EPIC-InterAct across eight European countries

Aims/hypothesis: Gene–macronutrient interactions may contribute to the development of type 2 diabetes but research evidence to date is inconclusive. We aimed to increase our understanding of the aetiology of type 2 diabetes by investigating potential interactions between genes and macronutrient intake and their association with the incidence of type 2 diabetes. Methods: We investigated the influen

The intracranial pressure curve correlates to the pulsatile component of cerebral blood flow

Current methods to measure cerebral blood flow (CBF) in the neuro critical care setting cannot monitor the CBF continuously. In contrast, continuous measurement of intracranial pressure (ICP) is readily accomplished, and there is a component of ICP that correlates with arterial inflow of blood into the cranial cavity. This property may have utility in using continuous ICP curve analysis to continu

Autonomic Neuropathy-a prospective cohort study of symptoms and E/I Ratio in normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes

Background: Autonomic neuropathy in diabetes, in addition to causing a range of symptoms originating from the autonomic nervous system, may increase cardiovascular morbidity. Our aim was to study the progression of autonomic neuropathy, based on symptom score and evaluation of an autonomic test, in persons with normal and impaired glucose tolerance and in patients with type 2 diabetes (T2D). Metho

Incidence of scoliosis in cerebral palsy : A population-based study of 962 young individuals

Background and purpose — Surveillance of scoliosis in individuals with cerebral palsy (CP) is important for ensuring timely diagnosis and identification of curve progression. We analyzed the incidence of scoliosis in relation to age, sex, and gross motor function in a population-based cohort of individuals with CP. Patients and methods — This was a prospective register study of all 1,025 individua

Economic evaluation of primrose-a trial-based analysis of an early childhood intervention to prevent obesity

Background: Childhood obesity is a major clinical and economic health concern. Alongside the clinical understanding of obesity, there is a growing interest in designing and implementing interventions that are worth their money given the scarce resources in the health care sector. This study is one of the first efforts to provide evidence by assessing the effects and costs of a population-based pri

Protozoan parasites in drinking water : A system approach for improved water, sanitation and hygiene in developing countries

Improved water, sanitation and hygiene (WASH) are significant in preventing diarrhea morbidity and mortality caused by protozoa in low- and middle-income countries. Due to the intimate and complex relationships between the different WASH components, it is often necessary to improve not just one but all of these components to have sustainable results. The objective of this paper was to review the c

Differences in unmet healthcare needs between public and private primary care providers : A population-based study

Aims: To investigate if any differences in unmet healthcare needs between persons registered at public and private primary care providers exist in Skåne (southernmost Sweden). Methods:The 2012 public health survey in Skåne was conducted with a postal questionnaire and included 28,029 respondents aged between 18 and 80 years. The study was cross-sectional. If the responder in the last three months

Impact of a multifactorial treatment programme on clinical outcomes and cardiovascular risk estimates : A retrospective cohort study from a specialised diabetes centre in Denmark

Objectives To investigate the impact of a multifactorial treatment programme in a real-life setting on clinical outcomes and estimated cardiovascular disease (CVD) risk. Design A retrospective observational cohort study, using data from the electronic medical records and national registers. Setting Tertiary diabetes centre in Denmark. Participants Patients with type 2 diabetes (n=4299) referred to

Addictive behaviors, social and psychosocial factors, and electronic cigarette use among adolescents : a population-based study

Objectives: The aim was to investigate associations between e-cigarette use and social and psychosocial factors and cigarette smoking, alcohol consumption, and narcotics use among adolescents attending 9th grade in primary school and 2nd grade in secondary school. Study design: Cross-sectional study. Methods: The public health survey among adolescents in Scania in 2016 includes pupils in grades 9

Decision support for bridge condition assessment

The paper presents the first steps of the development of a theoretical framework for a rational yet practical decision making process concerning the condition assessment of existing bridges in Sweden. The main focus is on how to choose the appropriate level of enhanced conditions assessment considering aspects of model sophistication, uncertainty consideration and knowledge content utilisation. A

Local civil society regimes: liberal, corporatist and social democratic civil society regimes in Swedish metropolitan cities

Academic debates on the role and position of civil society organisations (CSOs) in welfare states largely refer to policies and practices outlined at the national level. They therefore fail to recognise variations within nations. Based on a comparative case study of three Swedish metropolitan cities, this article illustrates the importance of local, contextualised analyses. Through the concept of Academic debates on the role and position of civil society organisations (CSOs) in welfare states largely refer to policies and practices outlined at the national level. They therefore fail to recognise variations within nations. Based on a comparative case study of three Swedish metropolitan cities, this article illustrates the importance of local, contextualised analyses. Through the concept of

Långsiktig kompetensförsörjning behövs i vården

Läkares utbildning har tre faser med skilda uppdrag och ansvar – från grundutbildning och vidareutbildning till specialistutbildning och sedan fortbildning. Grundutbildningen, men även vidareutbildningen, har ett särskilt ansvar för kompetensförsörjning baserat på hälso- och sjukvårdens långsiktiga behov, nationellt och internationellt [1]. Det förutsätter en analys av de arbetsuppgifter som läkar

Too Sharp for its Own Good – Tool Edge Deformation Mechanisms in the Initial Stages of Metal Cutting

© 2017 Metal cutting simulations have become an important part of cutting tool design and the research in the field in general. One of the most important aspects of modeling is the accuracy of the tool geometry. 3D microscopy is used for measuring the tool edge radius with good accuracy. However, especially with sharp tools, i.e. small tool edge radii, the measurements, no matter how accurate, are

Heat matters when matter heats – The effect of temperature-dependent material properties on metal cutting simulations

The goal of metal cutting research is to predict process conditions accurately with a model or a simulation, in order to optimize and develop the processes. Development of such a model requires understanding of multiple branches of physics and engineering such as continuum mechanics, thermodynamics, tribology and materials science. For an accurate model, each aspect of the process must be modelled

Dull punch line is not a joke – Worn cutting edge causes higher iron losses in electrical steel piercing

© 2018 Elsevier Ltd Electrical steel is used for the active parts in electrical machinery that form the magnetic circuits because the material experiences low iron loss, and thus, has superior magnetizing properties. A typical electrical sheet has a thickness of 0.5 mm and is punched into its final shape via a piercing process. Piercing causes large deformations and residual stresses in the narrow