Parkinson’s Disease (PD) is the most prevalent neurodegenerative movement disorder. Despite investigative efforts into the pathogenesis of the disease, the aetiology and mechanism of PD remains unknown, with multiple factors and cellular pathways known to play a part. But the genetic component of the disease, as well as enhanced vulnerability of the midbrain dopaminergic neurons of the Substantia

Many items of culture which are conveyed from one culture to another may take verbal form, and then constitute what Jakobson called "translation proper." If such diffusions involve a co-occurrent change of semiotic systems, they are of such a different nature, that we better reserve another term for it: transposition. Whether or not accompanied by transpositions, such as pictures, translational ev

Cerebral autoregulation is crucial for maintaining cerebral blood flow and perfusion. In recent years, the importance of cerebral oxygenation in syncope and orthostatic intolerance (OI) has received increased attention. Cerebral tissue oxygenation can be measured by using near-infrared spectroscopy (NIRS), which determines the ratio of oxygenated hemoglobin to total hemoglobin in cerebral tissue.

The importance of effective facility management in enabling organizations to function efficiently is widely recognized. Total Facility Management offers a comprehensive treatment of what facility management means to owners, operators, tenants, facility managers and professional advisors, as well as containing advice on how facilities can be better managed from a number of perspectives. It consolid

The alarming rates of extinction and degrading ecosystems call for new means of understanding and accounting for how people depend on nature. Ecosystem services (ES) is a contested but widely applied concept aiming to connect ecosystem functions to human wellbeing and to assess and account for how nature matters in decision-making. More diverse frameworks and ideas of value intended for assessment

Bastin et al (Reports, 5 July 2019, p. 76) claim that 205 gigatonnes of carbon can be globally sequestered by restoring 0.9 billion hectares of forest and woodland canopy cover. Reinterpreting the data from Bastin et al, we show that the global land area actually required to sequester human-emitted CO2 is at least a factor of 3 higher, representing an unrealistically large area.

Background: In 2001, the EU nickel directive was introduced to prevent contact allergy to nickel. Contact allergy to palladium and/or cobalt is often seen together with contact allergy to nickel. Objectives: To compare the contact allergy prevalence of nickel, palladium, and cobalt allergy before and after the introduction of the EU nickel directive in consecutive patients with dermatitis. Methods

Biomass is an essential sustainable and carbon-neutral energy source. Through thermochemical conversion processes, such as combustion and gasification, biomass can generally be used in boilers to provide heat and/or power. Biomass fuels contain varying amounts of potassium, chlorine and sulfur. The release of these elements, especially in the form of potassium chloride (KCl), in the thermal conver

In this paper, the authors examine how cultural background informs human-computer-interactions, particularly as pertaining to user experience (UX) and user interface design (UI). Prior studies suggest that East Asians are more likely to process information holistically while Westerners tend to engage with visual stimuli analytically. It is believed that such differences in information processing m

Objective: To investigate whether midlife atherosclerosis is associated with different dementia subtypes and related underlying pathologies. Methods: Participants comprised the cardiovascular cohort of the Swedish prospective population-based Malmö Diet and Cancer Study (N = 6,103). Carotid plaques and intima media thickness (IMT) were measured at baseline (1991–1994). Dementia incidence until 201

Introduction. This paper presents a theory-driven discussion on the role of facts in society, couched between a brief historical overview and a discussion of the contemporary situation, exemplified in particular by openly available web-based fact services. Implications for the conceptualisation of information literacy – and in particular information literacy in relation to today’s dominant algorit

This study presents an approach for partitioned fluid-structure interaction (FSI) applied to large structural deformations, where an incompressible turbulent solver is combined with a structural solver. The implementation is based upon two different open-source libraries by using MPI as a parallel communication protocol, the packages and OpenFOAM. FSI is achieved through a strongly-coupled scheme.

Nature-based solutions (NBS) focus on the material functioning of ecosystems as part of a transformative response to societal challenges. NBS represent a growing response to climate change with a range of interventions emerging across the world to address the causes and effects of climate change. The adoption of NBS is claimed to address a range of Sustainable Development Goals, including empowerm

BAKGRUND: Intresset för parasport har vuxit det senaste årtiondet. Andelen paraidrottare som elitsatsar ökar ochmånga prestationer går att jämföra med idrottare utan funktionsnedsättning. Deltagande i idrott innebär dock en ökadrisk för att drabbas av en idrottsrelaterad skada eller sjukdom (IRSS). IRSS är ett bekymmer inom flertalet idrotter,vilket kan leda till förlorad träningstid samt negativa