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Climate researcher Kevin Anderson visits Lund April 10 and 11

Professor Kevin Anderson is one of the leading experts in the world on climate change and has written a number of articles on the urgency for action. On April 10 & 11 he is visiting Lund. On Monday April 10, Kevin Anderson will hold a lecture at the public library in Lund from 18.00 to 19.30: Mitigation – but how fast?Politicians and negotiators always seem to use yesterdays requirements for the r

https://www.cec.lu.se/article/climate-researcher-kevin-anderson-visits-lund-april-10-and-11 - 2025-10-05

Lundaloppet predictive challenge 2017

Guess your time in Lundaloppet 2017 and express your uncertainty in your running time in which way you want! After the race on May 13th and the actual running times are known, we will evaluate the performances of all predictions. The results will be presented in June, where we will hand out several awards.Guess your time in Lundaloppet 2017 and express your uncertainty in your running time in whic

https://www.cec.lu.se/article/lundaloppet-predictive-challenge-2017 - 2025-10-05

National poisoning registers and toxicovigilance in different countries as models for Germany

As of 2019, Germany has still not been able to provide a national poisoning register and toxicovigilance for sufficient and reliable information on human exposure for the purpose of identification and assessment of toxic risk to the public. In particular, the USA acts as a special model, but France, the Netherlands, Switzerland, and Sweden also have efficient poisoning registers and toxicovigilanc

https://www.lupop.lu.se/article/national-poisoning-registers-and-toxicovigilance-different-countries-models-germany - 2025-10-05

Prediction of Lymph Node Metastasis in Breast Cancer by Gene Expression and Clinicopathological Models: Development and Validation within a Population-Based Cohort

More than 70% of patients with breast cancer present with node-negative disease, yet all undergo surgical axillary staging. We aimed to define predictors of nodal metastasis using clinicopathological characteristics (CLINICAL), gene expression data (GEX), and mixed features (MIXED) and to identify patients at low risk of metastasis who might be spared sentinel lymph node biopsy (SLNB). New publica

https://www.lupop.lu.se/article/prediction-lymph-node-metastasis-breast-cancer-gene-expression-and-clinicopathological-models - 2025-10-05

Developing and Launching a Research Participant Registry

A major challenge in clinical research today is the difficulty that studies have in meeting recruitment goals. Up to 48% of studies do not meet accrual goals within the specified timeframe, significantly delaying the progress of projects and the dissemination of findings. This pervasive problem is a recruitment crisis. We developed a representative, ethnically and racially diverse research partici

https://www.lupop.lu.se/article/developing-and-launching-research-participant-registry - 2025-10-05

National Spinal Cord Injury Registry of Iran (NSCIR-IR) – a critical appraisal of its strengths and weaknesses

The National Spinal Cord Injury Registry of Iran (NSCIR-IR) is a not-for-profit, hospital-based, and prospective observational registry that appraises the quality of care, long-term outcomes and the personal and psychological burden of traumatic spinal cord injury in Iran. Benchmarking validity in every registry includes rigorous attention to data quality. New publication in Chinese Journal of Tra

https://www.lupop.lu.se/article/national-spinal-cord-injury-registry-iran-nscir-ir-critical-appraisal-its-strengths-and-weaknesses - 2025-10-05

International Validation of the Danish Vascular Registry Karbase: A Vascunet Report

Vascunet has previously published an international comparison of registry data within vascular surgery. Data validity and completeness in participating registries is essential for a meaningful interpretation of differences between countries. The Vascunet collaboration has therefore developed a methodology for validation of international vascular registry data, previously used for validation of two

https://www.lupop.lu.se/article/international-validation-danish-vascular-registry-karbase-vascunet-report - 2025-10-05

Cause of death and significant disease found at autopsy

The use of clinical autopsy has been in decline for many years throughout healthcare systems of developed countries despite studies showing substantial discrepancies between autopsy results and pre-mortal clinical diagnoses. We conducted a study to evaluate over time the use and results of clinical autopsies in Sweden. We reviewed the autopsy reports and autopsy referrals of 2410 adult (age > 17)

https://www.lupop.lu.se/article/cause-death-and-significant-disease-found-autopsy - 2025-10-05

Swedish Inflammatory Bowel Disease Register (SWIBREG) – a nationwide quality register

Inflammatory bowel disease (IBD) is a chronic, inflammatory relapsing disease with increasing incidence. IBD research and long-term follow-up of patients have, however, been hampered by lack of detailed data on disease phenotype, patient-reported outcome measures, Physician Global Assessment, disease activity, and hospital-administered drugs. New publication in Scandinavian Journal of Gastroentero

https://www.lupop.lu.se/article/swedish-inflammatory-bowel-disease-register-swibreg-nationwide-quality-register - 2025-10-05

A colorectal cancer diet quality index is inversely associated with colorectal cancer in the Malmö diet and cancer study

The World Cancer Research Fund International has concluded strong evidence for that high intake of dairy products and foods containing dietary fiber and low intake of processed meat are associated with decreased risk of colorectal cancer (CRC). As food items are consumed together, it is important to study dietary patterns. New publication in European Journal of Cancer Prevention

https://www.lupop.lu.se/article/colorectal-cancer-diet-quality-index-inversely-associated-colorectal-cancer-malmo-diet-and-cancer - 2025-10-05

Role of healthcare databases and registries for surveillance of orphan drugs in the real-world setting: the Italian case study

Orphan drugs are medicines intended to treat, prevent, or diagnose a rare and serious condition. The collection of pre-marketing safety and efficacy data for orphan drugs is very challenging for several reasons related to the rarity of the diseases. This highlights the need for robust post-marketing evidence generation. Real-world data sources, such as claims databases, electronic healthcare recor

https://www.lupop.lu.se/article/role-healthcare-databases-and-registries-surveillance-orphan-drugs-real-world-setting-italian-case - 2025-10-05

Agreement between molecular subtyping and surrogate subtype classification: a contemporary population-based study of ER-positive/HER2-negative primary breast cancer

Oestrogen receptor-positive (ER+) and human epidermal receptor 2-negative (HER2–) breast cancers are classified as Luminal A or B based on gene expression, but immunohistochemical markers are used for surrogate subtyping. The aims of this study were to examine the agreement between molecular subtyping (MS) and surrogate subtyping and to identify subgroups consisting mainly of Luminal A or B tumour

https://www.lupop.lu.se/article/agreement-between-molecular-subtyping-and-surrogate-subtype-classification-contemporary-population - 2025-10-05

Patient Registries: An Underused Resource for Medicines Evaluation

Patient registries, ‘organised systems that use observational methods to collect uniform data on a population defined by a particular disease, condition, or exposure, and that is followed over time’, are potentially valuable sources of data for supporting regulatory decision-making, especially for products to treat rare diseases. Nevertheless, patient registries are greatly underused in regulatory

https://www.lupop.lu.se/article/patient-registries-underused-resource-medicines-evaluation - 2025-10-05

Methods for constructing treatment episodes and impact on exposure-outcome associations

To assess the impact on exposure time and outcome misclassifications, and consequent impact on exposure-outcome associations from treatment episode construction. We investigated the dosage assumptions of 1 unit per day, and 1 DDD per day, versus actual prescribed dosage under different handling of gaps and overlaps of prescriptions. New publication in European Journal of Clinical Pharmacology

https://www.lupop.lu.se/article/methods-constructing-treatment-episodes-and-impact-exposure-outcome-associations - 2025-10-05

What Is the Causal Interpretation of Sibling Comparison Designs?

Sibling comparison designs have long been used to assess causal effects of exposures for which randomized studies are impossible and measurement of all relevant confounding is unobtainable. The idea is to utilize the fact that siblings often share a lot of unobserved variables. Therefore, it is proposed that in certain cases, comparing siblings is equivalent to comparing exchangeable individuals,

https://www.lupop.lu.se/article/what-causal-interpretation-sibling-comparison-designs - 2025-10-05