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Lung cancer is the worldwide leading cause of death from cancer. Epigenetic modifications such as methylation and changes in chromatin accessibility are major gene regulatory mechanisms involved in tumorigenesis and cellular lineage commitment. We aimed to characterize these processes in the context of neuroendocrine (NE) lung cancer. Illumina 450K DNA methylation data were collected for 1407 lung

Seed dressing, i.e., the treatment of crop seeds with insecticides and/or fungicides, aiming to protect seeds from pests and diseases, is widely used in conventional agriculture. During the growing season, those crop fields often receive additional broadband herbicide applications. However, despite this broad utilization, very little is known on potential side effects or interactions between these

Background: Successful preclinical transplantations of porcine hearts into baboon recipients are required before commencing clinical trials. Despite years of research, over half of the orthotopic cardiac xenografts were lost during the first 48 hours after transplantation, primarily caused by perioperative cardiac xenograft dysfunction (PCXD). To decrease the rate of PCXD, we adopted a preservatio

Asymmetry of striatal dopaminergic deficits and motor symptoms is a typical characteristic of idiopathic Parkinson’s disease (PD). This study aims to characterise the trend of asymmetry in moderate-stage PD. We performed a 19-month longitudinal study in 27 patients with PET-CT imaging and appropriate clinical assessments. 11C-PE2I non-displaceable binding potential (BPND) was calculated bilaterall

The purpose of this study was to describe nurses’ experiences of promoting healthy aging in municipalities. A descriptive qualitative research design based on semi-structured interviews with 13 nurses was employed. The nurses described the importance of giving older adults the possibility to live as individuals, but also that the organization matters as too does the nurses’ own desire to work prof

OBJECTIVE: To determine how much people with late effects of polio are bothered by various impairments and their influence on everyday life. DESIGN: A mixed-methods design. SUBJECTS/PATIENTS: Seven women and 7 men (mean age 70 years) with late effects of polio. METHODS: Self-reported Impairments in Persons with late effects of Polio (SIPP) scale and face-to-face interviews. In SIPP, the participan

Climate change is an increasingly urgent, complex problem, with consequences threatening human and non-human lives across the globe. Legislative and citizen-driven responses are valuable but insufficient, and their practical feasibility is unclear. Emerging design research suggests embracing imaginative, creative approaches to support engagement with climate-change issues and inspire collective re

Abstract: In recent decades, increasing numbers of scholars and practitioners have rejected the conventional, “linear” view of economic activity (centered on “take, make, and dispose”) in favor of a “circular economy” perspective, which emphasizes the need for humans to live in harmony with Earth’s ecological system. As a consequence, various contemporary business models claim to draw inspiration

A prototype quasiparasitic thermal neutron beam monitor based on isotropic neutron scattering from a thin natural vanadium foil and standard He3 proportional counters is conceptualized, designed, simulated, calibrated, and commissioned. The European Spallation Source designed to deliver the highest integrated neutron flux originating from a pulsed source is currently under construction in Lund, Sw

DEBATE. Far from everyone who lives in Sweden has a secure housing situation. According to the National Board of Health and Welfare's latest national survey of 2017, there are about 33,000 homeless people in the country. A significant proportion of them are children. Due to the ongoing corona pandemic, many households are now threatened by unemployment and a deteriorating economy. If the state and

Allosteric communication within proteins is a hallmark of biochemical signaling, but the dynamic transmission pathways remain poorly characterized. We combined NMR spectroscopy and surface plasmon resonance to reveal these pathways and quantify their energetics in the glucocorticoid receptor, a transcriptional regulator controlling development, metabolism, and immune response. Our results delineat

In contrast to what is observed in aerobic uplands, microbial biomass and the presence of electron acceptors, such as iron oxides, play a crucial role in regulating soil organic C (SOC) mineralisation in paddy soils. However, the related underlying mechanisms are still poorly explored. We conducted an anaerobic incubation study to investigate changes in CO2 emissions from SOC and acetate (13C-labe

The water sector in Somalia is fragmented and needs coordination to establish a functioning water governance system. Therefore, commitments from all affected stakeholders are needed to support water resources development in Somalia. This paper proposed a water compact for Somalia that can address all water sector challenges to approach sustainability. The paper starts by analyzing water sector sta

Septic shock, a serious consequence of disseminated infection that has a high mortality, is due to a dysregulated, severe immune response triggered by the infection. Acute phase reactants play key roles in sepsis, for example, hepcidin regulating iron metabolism. Reticulocyte haemoglobin (Ret-He) depends on available iron in blood, indirectly regulated by hepcidin. This study aimed at exploring ra

The association between breast cancer risk defined by the Tyrer-Cuzick score (TC) and disease prognosis is not well established. Here, we investigated the relationship between 5-year TC and disease aggressiveness and then characterized underlying molecular processes. In a case-only study (n = 2474), we studied the association of TC with molecular subtypes and tumor characteristics. In a subset of

Purpose: Healthy spinal balance is dependent on spinal sagittal alignment. It is evaluated by several spinopelvic measures. The objective of this study is to investigate the effect of age and body mass index and the bone mineral density on the several vertebral measures and sagittal spinopelvic measurements. Methods: In this cross-sectional study, a total of 89 female patients were grouped accordi

The catalytic oxidation of CO on transition metals, such as Pt, is commonly viewed as a sharp transition from the CO-inhibited surface to the active metal, covered with O. However, we find that minor amounts of O are present in the CO-poisoned layer that explain why, surprisingly, CO desorbs at stepped and flat Pt crystal planes at once, regardless of the reaction conditions. Using near-ambient pr