The objective of this study was to develop a population pharmacokinetic–pharmacodynamic model of subcutaneously administered bupivacaine in a novel extended-release microparticle formulation for postoperative pain management. Bupivacaine was administered subcutaneously in the lower leg to 28 healthy male subjects in doses from 150 to 600 mg in a phase 1 randomized, placebo-controlled, double-blind

Electrical resistivity tomography (ERT) is a potential-based method for detecting internal erosion in the core of embankment dams using the electrodes installed outside. This study aims at evaluating the practical capability of ERT monitoring for detecting internal defects in embankment dams. A test embankment dam with in-built well-defined defects was built in Älvkarleby, Sweden, to assess differ

Glioblastoma multiforme (GBM) IDH-wildtype is the most prevalent brain malignancy in adults. However, molecular mechanisms, which leads to GBM have not been completely elucidated. Granulocyte colony-stimulating factor (GCSF), Granulocyte colony-stimulating factor receptor GCSFR, and Signal transducers and activators of transcription 3 (STAT3) have been involved in the occurrence and development of

This paper introduces the MinCan database that presents mine-level estimates for the Canadian mining industry with a persistent annual coverage between 1950 and 2022. These estimates are based on archival maps and a selection of historical sources, which follows a hierarchy of criteria-based credibility and standardization. The information contained in MinCan covers 947 mines and provides informat

AimTo describe the aetiology and clinical characteristics of acute peripheral facial palsy (PFP) in children and investigate the utility of the European Federation of Neurological Societies (EFNS) criteria for diagnosing Borrelia-related PFP (BPFP) based on cerebrospinal fluid (CSF) testing and the Centers for Disease Control and Prevention (CDC) criteria based on serology.MethodsWe retrospectivel

Texten är en essä utifrån nya översättningar av Ciceros De fato och Senecas De providentia, utgivna på Augusti bokförlag. På svenska heter boken Om ödet/Om försynen. Översättare är Lars Nyberg. I essän berättar jag även om den nya teknik som gjort det möjligt att avkoda de förkolnade bokrullarna i Herculaneum.

For the past months, Finland has been shaken by recurring strike waves, involving hundreds of thousands of workers in all sectors of the economy. The strikes are political, not directed at any particular company or related to bargaining demands. Instead, the primary target is the conservative Finnish government, and its plan to implement a wide set of policies aimed at improving the manufacturing

As of 2023, Human Rights is one of Lund University’s five profile areas. One aim of the Human Rights profile area is to strengthen interlinkages between research and education in the field of human rights and to facilitate collaboration between courses and education programmes at Lund University that explicitly or implicitly focus on human rights. This report is concerned with the latter of those As of 2023, Human Rights is one of Lund University’s five profile areas. One aim of the Human Rights profile area is to strengthen interlinkages between research and education in the field of human rights and to facilitate collaboration between courses and education programmes at Lund University that explicitly orimplicitly focus on human rights. This report is concerned with the latter of those t

InledningSverige lyfts ofta fram som ett av världens mest jämställda länder, samtidigt som forskning visar att det finns betydande skillnader mellan mäns och kvinnors livsvillkor. Sedan mitten av 1990-talet har jämställdhetsintegrering varit den rådande strategin inom svenska myndigheter och svensk förvaltning för att öka jämställdheten i samhället. Förenklat innebär detta att ett jämställdhetsper

Background: Intra-individual variability (IIV), a measure of variance within an individual's performance, has been demonstrated as metrics of brain responses for neural functionality. However, how mental fatigue modulates IIV remains unclear. Consequently, the development of robust mental fatigue detection methods at the single-trial level is challenging. New methods: Based on a long-duration flan

This paper presents a novel methodological approach, multi-dimensional measure of resource stratifcation in civil society (MMRSC). The method aims at mapping civil society organisations based on diferent types of resources for studying resource stratifcation in civil society. The approach is based on six indicators consisting of economic, political, and media resources, internal and external to ci