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Environmental and physiological controls on diurnal and seasonal patterns of biogenic volatile organic compound emissions from five dominant woody species under field conditions

Biogenic volatile organic compounds (BVOCs) play essential roles in tropospheric chemistry, on both regional and global scales. The emissions of large quantities of species-specific BVOC depend not only on environmental (temperature, T; photosynthetically active radiation, PAR), but also physiological parameters (i.e. net photosynthetic rate, Pn; transpiration rate, Tr; stomatal conductance, gs an

Germaine de Staël’s Réflexions sur le procès de la reine : An act of compassion?

In the foreword to the Mercure de France edition of Réflexions sur le procès de la reine, (1996 [1820, 1793]), Chantal Thomas, French historian and writer, writes that this apology in favour of Marie-Antoinette did not help the queen nor the author herself; on the contrary it only made the latter more unpopular. So why did Germaine de Staël write it? Mme de Staël and Marie-Antoinette did not shareIn the foreword to the Mercure de France edition of de Staël. (1996 [1793]. Réflexions sur le procès de la reine. Paris: Mercure de France), Chantal Thomas, French historian and writer, writes that this apology in favor of Marie-Antoinette did not help the queen nor the author herself; on the contrary it only made the latter more unpopular. So why did Germaine de Staël write it? Mme de Staël and M

Comprehensive transcriptomic profiling identifies breast cancer patients who may be spared adjuvant systemic therapy

Purpose: There is currently no molecular signature in clinical use for adjuvant endocrine therapy omission in breast cancer. Given the unique trial design of SweBCG91-RT, where adjuvant endocrine and chemotherapy were largely unadministered, we sought to evaluate the potential of transcriptomic profiling for identifying patients who may be spared adjuvant endocrine therapy. Experimental Design: We

A dual-action peptide-containing hydrogel targets wound infection and inflammation

There is a clinical need for improved wound treatments that prevent both infection and excessive inflammation. TCP-25, a thrombin-derived peptide, is antibacterial and scavenges pathogen-associated molecular patterns (PAMPs), such as lipopolysaccharide, thereby preventing CD14 interaction and Toll-like receptor dimerization, leading to reduced downstream immune activation. Here, we describe the de

Potential and limits of a colloid approach to protein solutions

Looking at globular proteins with the eyes of a colloid scientist has a long tradition, in fact a significant part of the early colloid literature was focused on protein solutions. However, it has also been recognized that proteins are much more complex than the typical hard sphere-like synthetic model colloids. Proteins are not perfect spheres, their interaction potentials are in general not isot

Recognition of personality disorder and anxiety disorder comorbidity in patients treated for depression in secondary psychiatric care

Objectives Depression is a common illness with substantial economic consequences for society and a great burden for affected individuals. About 30% of patients with depression do not respond to repeated treatments. Psychiatric comorbidity is known to affect duration, recurrence and treatment outcome of depression. However, there is a lack of knowledge on the extent to which psychiatric comorbidity

How fast can raptors see?

Birds, and especially raptors, are highly visual animals. Some of them have the highest spatial resolving power known in the animal kingdom, allowing prey detection at distance. While many raptors visually track fast-moving and manoeuvrable prey, requiring high temporal resolution, this aspect of their visual system has never been studied before. In this study, we estimated how fast raptors can se

Integrative discovery of treatments for high-risk neuroblastoma

Despite advances in the molecular exploration of paediatric cancers, approximately 50% of children with high-risk neuroblastoma lack effective treatment. To identify therapeutic options for this group of high-risk patients, we combine predictive data mining with experimental evaluation in patient-derived xenograft cells. Our proposed algorithm, TargetTranslator, integrates data from tumour biobank

Convection-enhanced delivery of temozolomide and whole cell tumor immunizations in GL261 and KR158 experimental mouse gliomas

BACKGROUND: Glioblastomas (GBM) are therapy-resistant tumors with a profoundly immunosuppressive tumor microenvironment. Chemotherapy has shown limited efficacy against GBM. Systemic delivery of chemotherapeutic drugs is hampered by the difficulty of achieving intratumoral levels as systemic toxicity is a dose-limiting factor. Although some of its effects might be mediated by immune reactivity, sy

Respiratory adenovirus infections in immunocompetent and immunocompromised adult patients

Adenovirus (AdV) can cause severe respiratory infections in children and immunocompromised patients, but less is known about severe AdV pneumonia in immunocompetent adults. In this retrospective study, we compared respiratory tract infections and pneumonia caused by AdV in immunocompromised and immunocompetent adult patients regarding clinical presentation and severity of infection. The results sh

Beta-blocker therapy and risk of vascular dementia : A population-based prospective study

There are a few studies that report cognitive impairment as a complication of treatment with beta- blockers. We aimed to evaluate the longitudinal association between use of beta-blockers, as a class, and incident risk of all-cause dementia, vascular dementia, Alzheimer's and mixed dementia in the prospective population-based Malmö Preventive Project. We included 18,063 individuals (mean age 68.2,