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In this article I examine the methodological and ethical rigor of a geographic profiling study and resulting article, published in 2016 in "Journal of Spatial Science", which identifies by name a candidate for being the artist known as Banksy.I demonstrate that the article is characterized by a number of methodological flaws which fundamentally undermine the researchers’ basis for determining Bank
This paper applied an ecocritical perspective on street art to expand on the notion that street art can have an impact on how we relate to urban public space. In doing so, it argued that street art is particularly well positioned to affect the way we think and act with regard to the environment.
Agricultural residues, such as wheat straw, are feasible substrates for ethanol fermentation provided that pentoses and hexoses can be converted efficiently. Separate hydrolysis and cofermentation (SHCF) constitute a framework for improvement of conversion efficiency, because it permits independent optimization of the enzymatic hydrolysis and cofermentation steps. A drawback is that the high gluco
The health among men and women with same-sex sexuality experience, i.e. attraction to and/or sexual relations with someone of the same sex, in Sub-Saharan Africa is an increasing public health concern. Prior research on men who have sex with men (MSM) has demonstrated that their healthcare utilisation is limited due to stigma and discrimination. However, little is known about the extent to which t
Second-generation ethanol from lignocellulose is a sustainable alternative that can partially replace fossil fuels. To be competitive with first generation ethanol from sugar and starch crops and fossil fuels, the conversion efficiency and ethanol yields of second-generation ethanol conversion processes must be improved. Improving the performance of the fermenting microorganism and efficiently con
Although genotype-by-environment interaction has long been used to unveil the genetic variation that affects Darwinian fitness, the mechanisms underlying the interaction usually remain unknown. Genetic variation at the dimeric glycolytic enzyme phosphoglucoisomerase (Pgi) has been observed to interact with temperature to explain the variation in the individual performance of the butterfly Melitaea
This article presents some results from a large monitoring campaign performed in 22 buildings around the world as part of International Energy Agency (IEA) Task 50 “Advanced lighting solutions for retrofitting buildings”. This article mainly addresses the work of Subtask D, which aims to demonstrate sound lighting retrofit solutions in a selection of representative, typical Case Studies. In order
In whey ultrafiltration (UF) production, two main problems are whey protein recovery and membrane fouling. In this study, membrane coupling protein transglutaminase (TG) catalysis protein cross-linking was investigated under different conditions to find out the best treatment. We found that the optimal conditions for protein recovery involved catalyzing whey protein cross-linking with TG (40 U/g w
Successful optimization of a given lead scaffold requires thorough binding-site mapping of the target protein particular in regions remote from the catalytic center where high conservation across protein families is given. We screened a 361-entry fragment library for binding to the aspartic protease endothiapepsin by crystallography. This enzyme is frequently used as surrogate for the design of re
Crystallographic screening of the binding of small organic compounds (termed fragments) to proteins is increasingly important for medicinal chemistry-oriented drug discovery. To enable such experiments in a widespread manner, an affordable 96-compound library has been assembled for fragment screening in both academia and industry. The library is selected from already existing protein-ligand struct
Today the identification of lead structures for drug development often starts from small fragment-like molecules raising the chances to find compounds that successfully pass clinical trials. At the heart of the screening for fragments binding to a specific target, crystallography delivers structural information essential for subsequent drug design. While it is common to search for bound ligands in
Fragment-based lead discovery (FBLD) has become a pillar in drug development. Typical applications of this method comprise at least two biophysical screens as prefilter and a follow-up crystallographic experiment on a subset of fragments. Clearly, structural information is pivotal in FBLD, but a key question is whether such a screening cascade strategy will retrieve the majority of fragment-bound
Denna artikel diskuterar en ny form av snabbt expanderande praktiker från tidigt 2000-tal och som erbjuds av privata företag eller entreprenörer (lekmannaterapeuter). I fokus står självförverkligande och helande. Jag har med hjälp av verktyg från Ritual Studies valt att analysera dessa praktiker som en form av individ-centrerade riter som designas för att lindra smärta och lågt självförtroende förThis article discusses a new form of practices which are offered by private companies or entrepreneurs (layman therapists) whose practices focusing on self-development and healing rapidly expanded in the early 2000s in Sweden. I have chosen to analyze these practices from a Ritual Studies perspective as individual-centered rites designed to remedy ill health and low self-esteem and to build new, p
Protein-lipid complexes have broad and specific effects against cancers of different origins. HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a complex of partially unfolded α-lactalbumin and oleic acid that kills a wide range of tumor cells but leaves healthy differentiated cells unaffected. Therapeutic efficacy of HAMLET has been demonstrated in several animal models, without appa
This paper explores the context, problems, quality, and challenges of local governance in four Central Asian countries: Kazakhstan, Kyrgyzstan, Tajikistan, and Uzbekistan. The prime focus is on the question of whether local governments in this region perform their functions in an effective and efficient way. It looks at the four conditions – contextual, structural, institutional and human resource
This thesis analyses how the capital structures of financial and non-financial firms affect each other and how shocks in the financial sector affect investments in non-financial firms. The thesis consists of three self-contained essays.The first essay provides new evidence on the capital structure determinants of non-financial firms and contributes to the discussion concerning the effect of a regu
We propose an end-to-end approach to describe the energy usage of video delivery within a content delivery framework, and use this to investigate the energy usage behavior of two popular coding schemes, namely, H.264/AVC and H.265/HEVC. Our study based on the proposed model is backed up by measurements of encoding and decoding energy usage of a sample video and shows that, from an end-to-end persp
