BACKGROUND:: There is a large interindividual variability in thiopurine metabolism. High concentrations of methylthioinosine-5'-monophosphate (meTIMP) and low concentrations of 6-thioguanine nucleotides (6-TGNs) have been associated with a lower response rate and an increased risk of adverse events. In this study, the role of inosine-5'-monophosphate dehydrogenase (IMPDH) for differences in metabo

The objective of this nationwide prospective cohort study is to find out the risk of breast cancer (BC) in relatives of patients with multiple BCs by laterality and age at diagnosis of first BC. Having family history of single (HR 1.8; 95 % CI 1.8-1.9) or multiple (HR 2.7; 95 % CI 2.6-2.9) BC was associated with higher risk of BC. Those with an FDR with contralateral BC at any age had the highest

Denna artikel handlar om vad som sker i mötet mellan straffrätt och socialrätt vid interorganisatorisk samverkan i en kontext av barnahus - där socialtjänst, hälso- och sjukvård samt polis- och åklagarmyndigheter samverkar under ett gemensamt tak kring utredningar av misstänkta brott mot barn. Utifrån ett rättssociologiskt institutionellt perspektiv presenteras och vidareutvecklas förståelsen för

Yoga can reduce blood pressure and has also been suggested to reduce inflammatory biomarkers and metabolic risk factors for cardiovascular diseases (CVDs). We aimed to assess the benefit of two yoga interventions on inflammatory biomarkers and metabolic risk factors in a high risk population in primary care.

In 2009, the European Paediatric Study Group for Haemolytic Uraemic Syndrome (HUS) published a clinical practice guideline for the investigation and initial therapy of diarrhea-negative HUS (now more widely referred to as atypical HUS, aHUS). The therapeutic component of the guideline (comprising early, high-volume plasmapheresis) was derived from anecdotal evidence and expert consensus, and the a

Background and purpose The Artelon CMC spacer is designed for surgical treatment of osteoarthritis (OA) in the carpometacarpal joint of the thumb (CMC-I). Good results using this degradable device were previously presented in a pilot study. We now present results from a larger randomized, controlled, multicenter study. Patients and methods 109 patients (94 females) with a mean age of 60 (42-83) ye

Studies of aquatic environments exposed to 17α-ethinylestradiol (EE2) have demonstrated detrimental effects on fish communities. However, much less is known about effects on macro-invertebrates and especially how long-term exposure may affect critical life stages and ultimately population dynamics. We studied the effects of EE2 on relevant endpoints for population growth in two common freshwater g

We report measurements of the primary charged-particle pseudorapidity density and transverse momentum distributions in p-Pb collisions at root s(NN) = 5.02 TeV and investigate their correlation with experimental observables sensitive to the centrality of the collision. Centrality classes are defined by using different event-activity estimators, i.e., charged-particle multiplicities measured in thr

Gasoline partially premixed combustion showed the potential of very high efficiency, emissions of nitrogen oxides (NOx) and soot below future emission regulations, and acceptable acoustic noise from idle up to 26 bar gross indicated mean effective pressure. For instance, gross indicated efficiencies in the range of 53 to 55 per cent were achieved in the whole load range keeping NOx below 0.30 g/kW

Low-dimensional, many-body systems are often characterized by ultraslow dynamics. We study a labelled particle in a generic system of identical particles with hard-core interactions in a strongly disordered environment. The disorder is manifested through intermittent motion with scale-free sticking times at the single particle level. While for a non-interacting particle we find anomalous diffusion

This paper studies a single product setting in which a firm can source from multiple suppliers. One supplier has unreliable capacity while other suppliers are reliable but have lower product quality. The addressed context (where a case study has been made) is disruptions due to sanctions which cause failure in the supply from the unreliable source. The important question which emerges here is how

Background: In experimental studies, the apolipoprotein D (APOD) and the sigma receptor type 1 (SIGMAR1) have been related to processes of brain damage, repair and plasticity. Methods: We examined blood samples from 3081 ischemic stroke (IS) patients and 1595 control subjects regarding 10 single nucleotide polymorphisms (SNPs) in the APOD (chromosomal location 3q29) and SIGMAR1 (chromosomal locati

We are constructing a High Resolution Tomographic Scintillation Camera System for small animal imaging. The system consists of a CsI(Tl) scintillator coupled to a military surplus image intensifier with a CCD camera focused on the output window. The system operates in photons counting mode and the spatial resolution is improved by centroid calculations for every photon interaction. The system can

Popular Abstract in Swedish Inom många områden, exempelvis inom sjukvården, blir det allt vanligare med situationer där stora mängder av bilder behöver analyseras. Ofta kan dessa bildmängder vara så stora att det tar för lång tid för en människa att gå igenom dem. Till exempel kan man med hjälp av datortomografi ta tredimensionella röntgenbilder av människor, något som görs på sjukhus idag. Att gåAt the core of many computer vision models lies the minimization of an objective function consisting of a sum of functions with few arguments. The order of the objective function is defined as the highest number of arguments of any summand. To reduce ambiguity and noise in the solution, regularization terms are included into the objective function, enforcing different properties of the solution. T

Recension av Kjell Östberg & Jenny Andersson, Sveriges historia. 1965–2012.