The role of the carbohydrates for the structure and functions of the plasma and tissue protein alpha1-microglobulin (alpha1m) was investigated by deletion of the sites for N-glycosylation by site-directed mutagenesis (N17,96-->Q). The mutated cDNA was expressed in a baculovirus-insect cell system resulting in a nonglycosylated protein. The biochemical properties of N17,96Q-alpha1m were compared to

BACKGROUND. Intrauterine growth retardation is one of the major causes of perinatal mortality and morbidity. To date, there are no reliable methods to detect brain damage in these patients. METHODS. We conducted a case-control study in tertiary NICUs from December 2001 to December 2003 with 42 intrauterine growth retardation infants and 84 controls. Routine laboratory variables, neurologic outcome

Abstract not available.

Annotated translation (with introduction and commentary) of Mao Zedong's three speeches at the Moscow Meeting of Representatives of Communist and Workers' Parties in November 1957.

The development of mature B lymphoid cells involves a highly orchestrated regulation of stage- and lineage-specific genes. In this study, we report an analysis of the human surrogate L chain VpreB promoter. The promoter has an overall homology of 56% to the mouse counterpart and displays a preB cell-restricted activity in transient transfections in cell lines. The promoter harbors three independen

Based upon earlier experimental work by our group, we have started a human immuno-gene therapy study. The goal is to study the effects of immunisation with autologous tumour cells expressing gene sequences for human interferon-gamma For more than two decades we have sought for efficient treatment against malignant gliomas. Our most successful treatment in the animal models is immuno-gene therapy w

BACKGROUND: Neonatal screening for alpha(1)-antitrypsin (AAT) deficiency was undertaken in Sweden between 1972 and 1974 when 129 infants with severe AAT deficiency (phenotype PiZ) were identified. The cohort has been followed up prospectively. METHODS: 124 PiZ subjects, still alive and still living in Sweden, were invited to a follow up examination at about 22 years of age. The check up included a

We conducted a cross-sectional pilot study on healthy pre-menopausal women (aged 45-50 years) living in Granada, in the south of Spain (n = 39) and Malmo, in the south of Sweden (n = 38) in order to compare their plasma carotenoid levels and to investigate the relationship between the differences in food consumption. Plasma concentrations of six carotenoids were measured using high performance liq

Chitosan was chosen as a natural polymer for dispersion of single walled carbon nanotubes (SWNT) based on its ability to efficiently solubilize SWNTs to form a stable dispersion. Moreover, chitosan films deposited on a surface of a glassy carbon (GC) electrode are mechanically stable. Further stabilisation of the chitosan film containing SWNT (CHIT-SWNT) was done by chemical crosslinking with glut

Abstract in German Es wurden die Ergebnisse von 116 Blutalkoholbestimmungen in Fällen klinisch behandelter und sämtlich überlebter Alkoholvergiftungen von Kindern bis zu 14 Jahren ausgewertet. In 84 Fällen war die nähere Untersuchung der Anamnese, der klinischen Symptomatik und des Verlaufes möglich. Jungen waren deutlich häufiger betroffen als Mädchen (Verhältnis 4:1). Das durchschnittliche AlterThis study is based on 116 blood alcohol estimations of intoxicated children up to 14 years of age; all these children recovered after several hours of clinical treatment. In 84 cases the data about the anamnesis, the neurological symptoms, and the clinical course could be evaluated in detail. The average age of children was 10 years; most of them (60%) were 11--14 years old. Sex distribution: 4 m

Based on spectra from F and G dwarf stars, we present elementalabundance trends in the Galactic thin and thick disks in the metallicityregime -0.8< [Fe/H < +0.4. Our findings can besummarized as follows. 1) Both the thin and the thick disks show smoothand distinct abundance trends that, at sub-solar metallicities, areclearly separated. 2) For the alpha -elements the thick disk showssignatures of c

Extremal control of Wiener type processes is considered. These models consists of a linear part followed by a static nonlinearity. We will consider nonlinearities having one extremum point. The purpose is to keep the output of the process as close as possible to the extremum point. The main problem in the control of this kind of processes is the non-uniqueness of the inverse of the nonlinearity. T