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Introduction: Child abuse is a global public health problem. It poses a threat to both physical and psychosocial well-being, resulting in serious consequences for the child, the family, and society. Radiographers are in a unique position to identify children at risk. In clinical practice, they may observe unusual interactions between children and their caregivers during radiographic procedures or
Epithelial-to-mesenchymal transition (EMT), driven by cues from the tumor microenvironment, is a critical initiator of metastatic progression. In breast cancer patients, elevated expression of cartilage oligomeric matrix protein (COMP) is associated with shorter survival and increased metastatic risk. Here, we investigated the role of COMP in regulating EMT in breast cancer. Breast cancer cells tr
Walking is a primary mode of transport in urban Africa, yet it remains unsafe, challenging, and unpleasant. In contrast, several European countries have implemented systematic policies to promote walking through Safe System principles. This study compares pedestrian safety in three African countries (Tanzania, Ghana, Zambia), with three European countries with excellence in road safety and Safe Sy
Denna forskningsrapport inom ramen för ett MSB uppdrag identifierar och kartlägger relevanta datamängder för att bedöma tvärsektoriella sårbarheter för samhällsviktiga verksamheter och kritiska infrastrukturer på nationell svensk nivå. Totalt identifierades 108 datamängder, varav 49 bedöms vara relevanta för analyser på nationell nivå, 54 på regional nivå och 37 på lokal nivå. Identifierad och sam
Micropollutant removal is a key component of the revised Urban Wastewater Treatment Directive (UWWTD) and can be achieved with ozonation. During ozonation, the composition of the wastewater matrix and the targeted treatment level for individual micropollutants or groups of such compounds affect ozone consumption. In this work, it was hypothesized that nitrite scavenging, the point of dosing (befor
Aims: Testing insulin resistance could help improve physician assessment of patients’ risk of prediabetes or type 2 diabetes (T2D), even among normoglycemic individuals. Methods: The longitudinal study followed 16,333 normoglycemic participants in a nation-wide employer-sponsored health assessment program starting in August 2020 with a median follow-up time of 2.9 years for incident prediabetes or
Background: Early electrocardiograph predates electronic amplification and therefore required innovative and highly sensitive instrumentation. Willem Einthoven's introduction of the string galvanometer in 1903 enabled recording of clinically useful electrocardiograms and established electrocardiography as a diagnostic method. Objectives: To describe the provenance and technical features of a uniqu
The islet β cells are the specific targets in an autoimmune process that eventually leads to the clinical onset of type 1 diabetes (T1D). The etiology is related to human leukocyte antigen (HLA) DR-DQ genetic factors that are necessary but not sufficient for disease development. The environmental etiology is related to enterovirus infection in early childhood resulting in two endotypes. In HLA DR4
In 2025, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health celebrates 75 years of leadership in diabetes research. The NIDDK serves people of the U.S. affected by or at risk for many chronic diseases, including diabetes and other endocrine, metabolic, and digestive disorders, by funding innovative research to develop better treatment
BackgroundPresence of a prosthetic joint entails a life-long risk of haematogenous periprosthetic joint infection (hPJI) during bacteraemia. For bacteraemia with Staphylococcus aureus the hPJI frequency has been described to be up to 40% and for streptococci up to 20%, with large variation among reported frequencies.ObjectivesWe aimed to investigate the hPJI frequency from bacteraemia with virulen
Objectives: Cystic fibrosis hepato-biliary involvement (CFHBI) is a common comorbidity in patients with CF and is associated with increased morbidity and mortality. The effect of the new and highly potent CF transmembrane conductance regulator modulator therapy, elexacaftor-tezacaftor-ivacaftor (ETI), on CFHBI, is still unclear. This study aimed to investigate the impact of ETI on liver stiffness
Stem cells are unique, undifferentiated cells that have the ability to both replicate themselves and develop into specialized cell types. This dual capability makes them valuable in the development of regenerative medicine. Current development in stem cell research has widened their application in cell therapy, drug discovery, reproductive cloning in animals, and cell models for various diseases.
Objective: Extremes of prepregnancy maternal BMI increase neonatal mortality and morbidity at term. They also increase the risk of extremely preterm (EP, i.e., <27 weeks' gestational age) births. However, the association between maternal BMI and outcomes for EP babies is poorly understood. Methods: We used a cross-country design, bringing together the following three population-based, prospective,
The European Union’s aim to decarbonize the building stock by 2050 requires significant reductions in the energy use for space heating and cooling. One such solution to decarbonization could be energy sharing between buildings. This paper presents the potential for energy saving and subsequent reduction in carbon emission with a low temperature district network in an energy community based in Malm
Background: Adverse skin reactions to continuous glucose monitors (CGMs) and devices for continuous subcutaneous insulin infusions (CSIIs) (“diabetes medical devices” (MDs)) are well known. However, epidemiological studies on prevalence and skin rash details are lacking. The objective of this study was to describe the prevalence and details of skin rash to diabetes MDs in adults with type 1 diabet
Alterations in mitochondrial metabolism in obesity may indicate disrupted communication between mitochondria and nucleus, and DNA methylation may influence this interplay. Here, we leverage data from the Finnish Twin Cohort study subcohort (n = 173; 86 full twin pairs, 1 singleton), including comprehensive measurements of obesity-related outcomes, mitochondrial DNA quantity and nuclear DNA methyla
Diagnosing sepsis in critical care remains a challenge due to the lack of gold-standard diagnostics. Calprotectin (S100A8/A9) has been proposed as a diagnostic marker to identify sepsis in critically ill patients. This study evaluated the diagnostic performance of calprotectin and C-reactive protein (CRP) to distinguish between sepsis and non-sepsis on intensive care unit (ICU) admission. Admissio
