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Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the second most common among children. AML is characterized by aberrant proliferation of myeloid blasts in the bone marrow and impaired normal hematopoiesis. Despite the introduction of new drugs and allogeneic bone marrow transplantation, patients have poor overall survival rate with relapse as the major challeng

AIMS, PATIENTS & METHODS: Dietary factors may regulate the epigenome. We aimed to explore whether a diet intervention, including excess sugar, affects the methylome in human sperm, and to describe the sperm methylome. We used Whole Genome Bisulfite Sequencing (WGBS) to analyze DNA methylation in sperm taken at three time points from 15 males during a diet intervention; i) at baseline, ii) afte

Background: Stroke is one of the major chronic non-communicable diseases (NCDs) with high morbidity, disability and mortality. The key to preventing stroke lies in controlling risk factors. However, screening risk factors and quantifying stroke risk levels remain challenging. Methods: A novel prediction model for stroke risk based on two-level feature selection and deep fusion network (SRPNet) is

To be a caregiver while also being next of kin is emotionally charged. This article discusses narratives of care that goes beyond what Amelia DeFalco calls “caregiving at the limit”, i.e. care necessary for basic survival. In these narratives of what we call desperate care, not only is life at stake, but the care is anxious and urgent, partly done against the will of the care recipient, and the ca

Throughout adulthood and ageing our brains undergo structural loss in an average pattern resembling faster atrophy in Alzheimer’s disease (AD). Using a longitudinal adult lifespan sample (aged 30-89; 2–7 timepoints) and four polygenic scores for AD, we show that change in AD-sensitive brain features correlates with genetic AD-risk and memory decline in healthy adults. We first show genetic risk li

The building and construction sector is responsible for a significant portion of embodied and energy related carbon emissions. Efforts to reduce this are reflected in the need for improved sustainability in the design, construction, and operation of structures such as buildings and bridges. This issue has become more prominent in recent decades due to the ongoing climate crisis. A historical revie

Studies addressing patients’ experiences of person-centered care (PCC) in the context of allogeneic hematopoietic stem cell transplantation (allo-HSCT) are scarce; hence, this study aimed to explore patients’ experiences of PCC, and its associations with individual characteristics and health-related quality of life, in the context of allogeneic stem cell transplantation. It is a cross-sectional su

Understanding the impact of various factors on train arrival delays is a prerequisite for effective railway traffic operating control and management. Existing studies model the train delay prediction problems using a single, generic equation, restricting their capability in accounting for heterogeneous impacts of spatiotemporal factors on arrival delays as the train travels along its route. The pa

Background: In addition to peripheral neuropathy of various kinds, diabetes can also cause central neuropathy, which among other things can manifest itself as premature cognitive dysfunction, often linked to vascular dysfunction. Although the link between diabetes and cognitive dysfunction was discovered more than 100 years ago and has important clinical implications, this diabetes complication re

Altricial songbirds transform themselves from naked poikilotherms to fully feathered endothermic homeotherms over a matter of days from hatching to fledging. The ontogeny of endothermy is a developmental milestone for birds that not only face warmer average temperatures, but also increasingly frequent cold snaps and extreme weather. The timing of development of endothermy has been studied in altri

BackgroundPolypharmacy has been linked with social isolation and loneliness among older people. The roles of different medication groups to this association are unclear. The aim of this study was to examine associations of fall-risk-increasing drugs (FRIDs) and cardiovascular drugs with loneliness and social isolation.MethodsThis cross-sectional study included 6714 adults aged 60 years and above l

The survival rate of patients with glioma has not significantly increased in recent years despite aggressive treatment and advances in immunotherapy. The limited response to treatments is partially attributed to the immunosuppressive tumor microenvironment, in which regulatory T cells (Treg) play a pivotal role in immunologic tolerance. In this study, we investigated the impact of complement facto

Background: Women with idiopathic pulmonary arterial hypertension (IPAH) have been found to have a worse haemodynamic status at diagnosis, but better survival than men. Over the past decade, demographics have changed and new treatments have become available. The objective of this study was to investigate sex differences in an incident IPAH population diagnosed between 2008 and 2016.Methods: Differ