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Insulin secretion from pancreatic beta cells is a fundamental physiological process, and its impairment plays a pivotal role in the development of diabetes. Mathematical modeling of insulin secretion has a long history, both on the level of the entire body and on the cellular and subcellular scale. However, little direct communication between these disparate scales has been included in mathematica
Type 1 diabetes is a chronic disease characterized by severe insulin deficiency and hyperglycemia, due to autoimmune destruction of pancreatic islets of Langerhans. A susceptible genetic background is necessary, but not sufficient, for the development of the disease. Epidemiological and clinical observations underscore the importance of environmental factors as triggers of type 1 diabetes, current
Previous research has found that weak institutions can hamper investment and alter patterns of trade. However, little is known about the impact of institutional quality on offshoring. This lack of knowledge is surprising, given that offshoring has become an important part of many firms' internationalization strategies. This study uses detailed firm-level data for the 1997-2005 period to examine th
In this study, user participation is suggested as a means, a process and role-playing between system users and developers in systems development. User participation in object-oriented contexts is observed from methodological and practical perspectives as a combined field of study. From the methodological perspective, three object-oriented methods are assessed according to NIMSAD, a method evaluati
Abstract in French Cet article pose la question de savoir s’il existe une corrélation entre le niveau grammatical et le niveau lexical dans la production écrite d’apprenants de français langue étrangère. Nous avons appliqué un certain nombre d’indices quantitatifs et lexicaux et un indice grammatical à 40 textes en français, écrits par deux groupes d’apprenants adultes suédophones se situant à des
Biomass gasification for energy or hydrogen production is a field in continuous evolution, due to the fact that biomass is a renewable and CO2 neutral source. The ability to produce biomass-derived vehicle fuel on a large scale will help to reduce greenhouse gas and pollution, increase the security of European energy supplies, and enhance the use of renewable energy. The Varnamo, Biomass Gassifica
Climatic conditions during the winter in countries situated in the north can be considered severe. This is especially true for hydraulic structures, such as hydro power structures, dams, harbours, canals and some bridge foundations. Freezing of concrete in contact with unfrozen fresh water may have a considerable impact on the deterioration process of concrete. This paper presents results obtained
In this article, we describe the integration of logistics after Mergers and Acquisitions (M&As) of firms within the same industry and, same industry level (i.e. horizontal M&As). First, we present a review of the literature on M&As and conclude that operational issues, in general, and logistics issues, in particular, have received little attention. In parallel with the literature revie
