Individuals with rapidly progressing atherosclerotic plaques are at higher risk of experiencing acute complications. Currently, we lack knowledge regarding factors in human plaque that cause rapid progression. Using the 14C bomb-pulse dating method, we assessed the physical age of atherosclerotic plaques and which biological processes were associated with rapidly progressing plaques. Interestingly

Objectives: Type I interferons (IFNs) are central and reflective of disease activity in systemic lupus erythematosus (SLE). However, IFN-α levels are notoriously difficult to measure and the type I IFN gene signature (IGS) is not yet available in clinical routine. This study evaluates galectin-9 and an array of chemokines/cytokines in their potential as surrogate markers of type I IFN and/or SLE d

Autoantigen discovery is a critical challenge for the understanding and diagnosis of autoimmune diseases. While autoantibody markers in current clinical use have been identified through studies focused on individual disorders, we postulated that a reverse approach starting with a putative autoantigen to explore multiple disorders might hold promise. We here targeted the epidermal protein transglut

Cities across the world are increasingly labelling themselves as smart in one way or another. At the same time, this smartness appears amorphous or invisible in its built urban environment. Critical researchers writing on the smart city regularly express confusion or exasperation about precisely the difficulty to locate the smart in the city. Visibility of the smart city is not a given. This artic

This review presents the status and outlook for shared energy systems (SES) and fifth-generation district heating and cooling (5GDHC). It provides an overview of the technical and functional knowledge encompassing design and development, operational and system architecture, and control and decision support systems of these technologies. The review also presents different tools and models found in

BACKGROUND: Costs and a low total number of cases may be obstacles to the successful implementation of a paediatric robotic surgery programme. The aim of this study was to evaluate a decade of paediatric robotic surgery and to reflect upon factors for success and to consider obstacles.MATERIALS AND METHODS: All children operated on with robotic-assisted laparoscopic surgery between 2006 and 2016 w

Superantigens (SAgs) are bacterial enterotoxins produced by Staphylococcus aureus. Staphylococcal enterotoxin type A (SEA), a staphylococcal superantigen, has been shown to bind to the cytokine signalling receptor glycoprotein 130 (gp130). The structural details, as well as the exact physiological role of this interaction, remain unclear. Here, we describe the structural details of the SEA–gp130 c

The “long nineteenth century” in European history, reaching from 1789 to 1914, is a chronological concept introduced by the British historian Eric Hobsbawm. The first part of this long century, described in his book The Age of Revolution, 1790-1848, was marked in the Nordic countries by conflicts between reform-oriented liberal forces and recalcitrant conservatives. This conflict played out politi

The number of seals in the Baltic Sea has increased dramatically in recent years. While growing seal populations are associated with a thriving marine environment, seals interact with coastal fisheries causing significant damages to catches and gears. One fishery that is severely affected is the coastal cod fishery where the negative impact of seals is believed by many to threaten the existence of

Spinal cord injury (SCI) challenges many aspects of life. Common secondary health conditions are sensorimotor impairments, autonomic dysfunction affecting bowel, bladder, sexual and cardiovascular function, pressure ulcers, pulmonary dysfunction, pain and psychological distress. Primary rehabilitation and lifelong follow-up from a specialized interdisciplinary rehabilitation team is needed to atta

This article proceeds from the question: how do prices in markets work? In socioeconomic theories, I find two answers to this question. The structural-coordinative approach explains prices as outcomes—coordinative effects of pricing scripts installed by exogenous, institutionalized social structures. The performative-epistemological approach explains prices as market devices—endogenous performativ

A Circular Economy (CE) calls for the value of materials and products to be maintained and recovered through narrowing, closing, and slowing loops. However, there remain challenges in moving up the waste hierarchy and not only recycling materials from products, but also capturing value through reuse of components in refurbished and repaired products. In this paper, we examine the practice of “harv