The role of mammalian Transient Receptor Potential Ankyrin 1 (TRPA1) as a mechanosensor is controversial. Here, we report that purified human TRPA1 (hTRPA1) with and without its N-terminal ankyrin repeat domain responded with pressure-dependent single-channel current activity when reconstituted into artificial lipid bilayers. The hTRPA1 activity was abolished by the thiol reducing agent TCEP. Thus

The incidence of acute appendicitis and the total number of appendectomies performed in the adult population admitted to our medical center are both decreasing. The cause is not clear. Better nutrition and the wide-spread use of antibiotics are two possible factors which come to mind, but we know of no scientific evidence that these are responsible. There has been a slight decrease in the mean die

Multifunctional buildings are characterized by multiple functions located within the same building. In this report specific problem areas are identified by the means of interviews and previous method development. The risks identified consider multifunctionality and antagonistic attacks. As a result from the previous method developed and the interviews, reference scenarios are suggested and conclus

A small population of Primula elatior has recently been found in a virgin swampy forest close to the southeastern shore of lake Ringsjon in Stehag parish. Here it grows in fully natural vegetation together with e.g. Anemone ranunculoides, Paris quadrifolia, Listera ovata, Ranunculus auricomus and Viola epipsila and there are no reasons to suspect that the population is anything but spontaneous. Un

OBJECTIVE- We studied differences between patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes, and classical type 1 diabetes diagnosed after age 35 years. RESEARCH DESIGN AND METHODS- Polymorphisms in HLA-DQB1, INS, PTPN22, and CTLA4 were genotyped in patients with LADA (n = 213), type 1 diabetes diagnosed at >35 years of age (T1D(>35y); n = 257) or 35y) and type 2 diabetic

Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF)

When different polling organisations conduct political party preference polls at different times, different parties might be reported. If the estimated voter shares of these polls are combined into a time series we obtain a compositional time series, but with varying number of parts, thus prohibiting the use of standard compositional time series analysis tools. We discuss the problem and suggest a

Further characterization of the post-cardiac arrest syndrome (PCAS) is essential to better understand the mechanisms resulting in injury and death. We investigated serial serum concentrations of the stress hormone c-terminal provasopressin (CT-proAVP or copeptin), the cardiac biomarker MR-proANP and a biomarker of oxidation injury, Peroxiredoxin 4 (Prx4) in patients treated with mild hypothermia (

Aortic stenosis (AS) shares risk factors with atherosclerotic vascular disease. Carotid intima-media thickness (IMT) and plaque may reflect the cumulative damage from exposure to different atherosclerotic risk factors. We examined the relationship of carotid IMT and plaque with incident AS in a prospective population-based study.