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Patents and entrepreneurship: The impact of opportunity, motivation and ability
Attenuation of Experimental Atherosclerosis by Interleukin-19.
Interleukin-19 (IL-19) is a putative Th2, anti-inflammatory interleukin. Its expression and potential role in atherogenesis are unknown. IL-19 is not detected in normal artery and is expressed to a greater degree in plaque from symptomatic versus asymptomatic patients, suggesting a compensatory counter-regulatory function. We tested whether IL-19 could reduce atherosclerosis in susceptible mice an
ATG16L1 Expression in Carotid Atherosclerotic Plaques Is Associated With Plaque Vulnerability.
Autophagy has emerged as a cell survival mechanism critical for cellular homeostasis, which may play a protective role in atherosclerosis. ATG16L1, a protein essential for early stages of autophagy, has been implicated in the pathogenesis of Crohn's disease. However, it is unknown whether ATG16L1 is involved in atherosclerosis. Our aim was to analyze ATG16L1 expression in carotid atherosclerotic p
TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives.
Thiazide diuretics have been recommended as a first-line antihypertensive treatment, although the choice of 'the right drug in the individual essential hypertensive patient' remains still empirical. Essential hypertension is a complex, polygenic disease derived from the interaction of patient's genetic background with the environment. Pharmacogenomics could be a useful tool to pinpoint gene varian
1C.07: PRONEUROTENSIN INDEPENDENTLY PREDICTS CARDIOVASCULAR DISEASE. THE MALMÖ PREVENTIVE PROJECT.
Neurotensin is released from the gut after fat intake and has a role in appetite regulations. Proneurotensin is a stable fragment of the neurotensin precursor hormone and fasting plasma proneurotensin levels have shown to be significantly associated with the development of cardiovascular disease in middle aged participants of the Malmö Diet and Cancer Study. Here, we aimed at replicating the initi
Evidence for altered inflammatory and repair responses in symptomatic carotid plaques from elderly patients.
Most acute cardiovascular events are caused by rupture of an atherosclerotic plaque. The incidence of cardiovascular events increases with age and inflammation is generally considered to be the main cause of increased plaque vulnerability. However, the relationship between age and plaque inflammation has not yet been fully clarified. The aim of our study was to determine if age-dependent plaque vu
Outcome of Ischemic Foot Ulcer in Diabetic Patients Who Had no Invasive Vascular Intervention.
OBJECTIVE/BACKGROUND: There is limited information regarding outcome in patients not available for revascularisation. Our aim was to identify factors related to ulcer healing in diabetic patients with severe peripheral arterial disease who were not available for revascularisation. METHODS: Diabetic patients with a foot ulcer, consecutively presenting at a multidisciplinary foot centre with systoli
Plasma level of the endogenous sodium pump ligand marinobufagenin is related to the salt-sensitivity in men.
Salt-induced elevation of the endogenous digitalis like sodium pump ligand marinobufagenin (MBG) in the Dahl salt-sensitive rats resulted in elevated blood pressure (BP). Here, we tested, in humans, whether MBG levels are related to ambulatory 24-h BP (ABP), controlled long-term increase of salt-intake induces changes in MBG and any salt-induced change in MBG is related to salt sensitivity.
Birkaborna med föremål från finska fastlandet, vilka var de?
Changing Customs in the late 1990s
The Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes: The EPIC-InterAct Study.
Observational studies show an association between ferritin and type 2 diabetes (T2D), suggesting a role of high iron stores in T2D development. However, ferritin is influenced by factors other than iron stores, which is less the case for other biomarkers of iron metabolism. We investigate associations of ferritin, transferrin saturation (TSAT), serum iron, and transferrin with T2D incidence to cla
Motivational Practice : Insights from the Classroom
Exceptions and limitations (27 UPCA)
The UPCA for the first time establishes harmonized exceptions and limitations to the effects of granted patent rights. Previously these were the sole province of national law but a with a degree of similarity.This chapter briefly analyses the historical origin, legal nature and scope of Article 27 UPCA, the future harmonizing effect of UPCA patent limitations, followed by a discussion on each limi
Advancing Archaeological Research : The Contribution of Spatial Technologies
Electric safety challenges with a conductive Electric Road System - Chassis potential modeling and measurement -
Investigating the Effects of MWE Identification in Structural Topic Modelling
Multiword expressions (MWEs) are common word combinations which exhibit idiosyncrasies in various linguistic levels. For various downstream natural language processing applications and tasks, the identification and discovery of MWEs has been proven to be potentially practical and useful, but still challenging to codify. In this paper we investigate various, relevant to MWE, resources and tools for
Alternative care practitioners: Creating commitment in an unstructured occupation
VARP
The facsimile of The Rudiments or Principles of the German flute : the first English translation of Principes de la Flute Traversiere ou Flute d’Allemagne (1707) by Jacques Hotteterre Le Romain
The present facsimile of The Rudiments or Principles of the German flute (1729)—now republished for the first time since 1729—is a separate supplement to the comparativestudy Les Traditions en Mouvement Principes de la Flute Traversiere ou Flute d’Allemagne (1707) by Jacques Hotteterre Le Romain and The Rudiments or Principles of the German flute (1729) the first English translation of Hotteterre’