Populärvetenskaplig sammanattning: Syftet med detta arbete är att dels försöka finna dygnsvariationer i koncentrationen av fina aerosoler, dels att försöka förklara vad dessa kan bero på i den mån det är möjligt. Syftet inkluderar även att undersöka aerosolernas långväga transporter för att härigenom ta reda på varifrån partiklarna kommer ur ett regionalt perspektiv. För att lösa uppgiften utnyttj

The object of this study was to try to comprehend, how the rehabilitaion of individuals towards employment and beeing able to earn their own living, could be facilitated through co-operative actions from the concerned local authorities. This comprehension was founded on the narratives from individuals, about their needs and qualifications. In order to reach this object, I interviewed participants

Accumulating evidence shows that immune cells play an important role in atherosclerosis. Most attention has focused on the role of different T cell subsets, whereas the possible involvement of B cells has been less studied. In this study, we assessed the association of 2 different B cell subsets, CD19(+)CD40(+) and CD19(+)CD86(+) B cells, with risk for development of acute cardiovascular events.

Background-eQTL analyses are important to improve the understanding of genetic association results. We performed a genome-wide association and global gene expression study to identify functionally relevant variants affecting the risk of coronary artery disease (CAD). Methods and Results-In a genome-wide association analysis of 2078 CAD cases and 2953 control subjects, we identified 950 single-nucl

“The Future is distributed: a vision of sustainable economies” is a collection of case studies on distributed economies, a concept describing sustainable alternatives to the existing business models. The authors of this publication are international Masters students of the Environmental Sciences, Policy and Management Programme at the International Institute for Industrial Environmental Economics

Allvarliga tillbud och olyckor inom flygtrafiken är relativt ovanligt, men när de inträffar ställs höga krav på kabinpersonalens förmåga att uppträda auktoritativt och effektivt. Det är dock inte bara vid ett direkt olyckstillbud det ställs stora krav på kabinpersonalens förmåga att hantera kritiska situationer. Det finns en hel flora av incidenter som kräver professionell hantering, t ex när passAlthough serious accidents or near-accidents are relatively rare in airline traffic, when they occur cabin attendants are expected to act effectively and with authority. However, the ability of cabin attendants to intervene professionally is also called for in other critical situations, such as when incidents that are frightening for the passengers occur or when passengers suddenly become ill. The

Diabetes mellitus is a lifelong, incapacitating disease affecting multiple organs. Presently, type 2 diabetes (T2D) can neither be prevented nor cured and the disease is associated with devastating chronic complications. These complications impose an immense burden on the quality of life of patients and account for about 12% of direct health care costs in Europe. Genetic analysis will increase our

Precision medicine utilizes genomic and other data to optimize and personalize treatment. Although more than 2,500 genetic tests are currently available, largely for extreme and/or rare phenotypes, the question remains whether this approach can be used for the treatment of common, complex conditions like obesity, inflammation, and insulin resistance, which underlie a host of metabolic diseases.

Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 signi

Exocytosis is the mechanism by which a vesicle inside the cell fuses with the plasma membrane to release its contents into the extracellular environment. The process might sound trivial but reduced expression or mutations in genes involved can cause a variety of disease states. The exocytotic process is a necessary part of neurotransmitter release from the pre-synaptic side into the synaptic cleft

Genome wide association studies (GWAS) for fasting glucose (FG) and insulin (FI) have identified common variant signals which explain 4.8% and 1.2% of trait variance, respectively. It is hypothesized that low-frequency and rare variants could contribute substantially to unexplained genetic variance. To test this, we analyzed exome-array data from up to 33,231 non-diabetic individuals of European a