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Two specific areas of development in echocardiography are assessment of left ventricular (LV) diastolic function and myocardial ischemia. This thesis describes echocardiographic methodology in these two areas. In the first study, two new echocardiographic methods, the early diastolic flow propagation velocity (Vp) and the early diastolic atrioventricular plane downward slope (EDS), were tested as

Time-of-flight (TOF) techniques for energy analysis have been common in electron spectroscopy for many decades. TOF-based electron spectrometers benefit from higher transmission and information rate compared to their main competitor: the hemispherical analyser; the drawback being their lower energy resolution. However, the advent of angle-resolved TOF spectrometers for electron energy analysis cha

Recombinant antibody microarrays have advanced into indispensable tools for large-scale, high-throughput multiplexed serum proteomics. This thesis, based upon five original papers, deals with the development of an in-house designed antibody microarray platform, and its applications for serum profiling of pancreatic disease. Pancreatic cancer is the 4th deadliest cancer, with a 5-year survival rat

This thesis presents experimental results related to laser plasma accelerators. These rely on very different principles from conventional particle accelerators. They are able to accelerate particles over a very short distance and produce synchrotron x-rays at the same time, potentially providing a compact particle accelerator and x-ray source for many future applications. The laser pulses used in

Popular Abstract in English Low fuel consumption, and reduced exhaust emissions, as well as improved performance and durability become much more important than before for the vehicle industry. These requirements lead to a number of additional equipment installed in the vehicles. All these efforts increase the operating temperature in the engine compartment and reduce the available free space in thCross flow heat exchangers made from aluminum are common as radiators in vehicles. However, due to the increasing power requirement and the limited available space in vehicles, it is extremely difficult to increase the size of heat exchangers (HEXs) placed in the front of vehicles. Placing the heat exchanger on the roof or at the underbody of vehicles might offer opportunity to increase the size o

The aim of the present thesis was to enhance our understanding of social support for physical activity among adolescents. Earlier findings show inconsistent results with regard to the importance of social support. The present thesis includes three empirical studies examining adolescents (16-18 years) during their years in high-school. Study I was a cross-sectional quantitative study that concluded

This dissertation investigates the possibilities and limitations of time-dependent many-body perturbation theory by studying small Hubbard clusters for which the exact solution is available. The first part of the thesis is comprised of a short introduction to the concepts and methodologies used. The second part consists of an review of the main findings of the thesis and a short summary of four

As the ultimate workhorses of the living things, proteins undergo significant regulatory activity throughout the lifetime of a cell or an organism. Many complex diseases effect the protein composition, expression or modification in the cells or tissues they arise in. It is then no surprise that proteomics is a field full of promise, one which is expected to generate significant insights towards fu

Oxidative stress can cause damage to DNA, proteins and lipids and is associated with inflammation and various human diseases as cancer, atherosclerosis, and autoimmune diseases. Polyphenol-rich diet, such as fruits and berries, may act as antioxidants and prevent oxidative stress and, thereby, associated diseases. Administration of lactic acid bacteria (LAB) can affect the microflora in the gastro

The objective was to develop and validate methods for single photon emission computed tomography, SPECT, allowing quantitative physiological and diagnostic studies of lung and heart. A method for correction of variable attenuation in SPECT, based on transmission measurements before administration of an isotope to the subject, was developed and evaluated. A protocol based upon geometrically well de

The Helianthemum oelandicum complex shows considerable morphological variation across its geographic distribution in Europe and western Asia. By combining four primer pairs and four restriction enzymes I identified nine cpDNA haplotypes with distinct geographical distributions. Two haplotypes were most frequent over most of the range; one in western Europe and one in eastern Europe. Moreover, diff

The death of a parent during childhood is a major traumatic event. While there is a good understanding of the early-life effects of parental loss, the evidence regarding its impact on adult mortality is still scarce. Accordingly, the aim of this article is to study the long-term consequences of parental loss on mortality with a particular focus on differences by socioeconomic status (SES) of the f