Filtyp
The purpose of this study has been to investigate the social consequences of unemployment and to give a possible interpretation of unemployment experiences through the application of the economy-shame model. It intends to put forward and show the significance of economic stress in combination with the feeling of shame as a factor important for the understanding of differences in unemploy-ment expe
Parkinson's disease (PD) is the second most common neurodegenerative disease and affects 2% of the population over 65 years of age. The disease is characterized by the progressive loss of dopaminergic neurons. Over time, symptoms increase and, in particular, lead to a dramatic slowness of movements. Unfortunately, when the fi rst symptoms are discovered, more than 50% of the dopaminergic neurons a
Neurodegenerative disorders are characterized by a progressive cell-death in the brain, and loss of different functions in the patient. Today, there are no cures for any of the various diseases. Parkinson's disease is a neurodegenerative disorder with a prevalence of 0.1% and the first symptoms usually start to appear between 50-60 years of age with rigidity, tremor, bradykinesia and postural abno
This dissertation, which is an analysis of the entrepreneur at the micro level, supplements and underpins the understanding and use of the entrepreneur as an agent of social change in the analysis of economic change at the macro level. The aim of the thesis is firstly to seek out and identify businessmen of our time who claim to be innovative, and secondly to un-dertake a qualitative study and ana
In this thesis mechanisms of neuronal damage were investigated in an experimental stroke model i.e focal ischemia. The influence of SD-induced calcium transients on neuronal damage were studied in animals with reduced energy supply. The influence of bioenergetic failure on K+e concentration and Ca2+e homeostasis were also investigated in transient focal ischemia. Moreover, the free radical formati
Background - The effects of intervention can be evaluated in different ways, and objective measurements of changes in lung function are commonly used as the outcome measure. Patient-reported outcome (PRO) is an umbrella term used for all patient-based assessments. One important PRO is health-related quality of life (HRQL), which may be used as an evaluative or discriminative measure. Objectives -
Proteins carry out the instructions encoded in genes and are crucial for many important tasks in the living organism. Often the specific three dimensional structure, or fold, of a protein enables it to carry out a given task. It is an open question whether protein folds have arisen independently or whether mutations to existing protein sequences have caused switches to new folds. In the main part
This thesis deals with different aspects of fatigue crack propagation in IN718. The ultimate objective of the work is to gain understanding of the fatigue process, from the macroscopic stress-strain relations to microscopic fatigue crack growth mechanisms. First, the stress-strain relations, which are fundamental in order to understand what the material encounter, are dealt with. The high temperat
Engagement in daily activities is central for people’s health and well-being. Today, our activity arenas mostly cover great geographical areas, and to reach different activities we must travel. However, people with functional limitations are sometimes restricted in their travelling. In order to investigate accessibility problems in different travel chains, the overarching objective of this thesis
Streptomycetes are Gram-positive bacteria with a complex developmental life cycle. They form spores on specialized cells called aerial hyphae, and this sporulation involves alterations in growth, morphogenesis and cell cycle processes like cell division and chromosome segregation. Understanding the developmental mechanisms that streptomycetes have evolved for regulating for example cell division i
Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are omega-3 fatty acids, which have health promoting effects. Since they are highly prone to oxidation, they should be protected, in particular DHA. Several lipids containing DHA were evaluated with respect to the ability of the lipids to protect DHA against peroxidation using an HPLC method developed as part of this research. Furthermore,
Under Indonesia's authoritarian New Order regime of President Suharto, the role envisaged for the small nationalist-Christian coalition the Indonesian Democratic Party (PDI) was that of a pliant state corporatist party, the existence of which was meant to demonstrate the ostensibly democratic character of the regime. From the second half of the 1980s, however, the party began to develop in a criti
An efficient transfer of energy in molecular systems has proven to be of fundamental importance both in nature and industrial applications. The ability of molecules to work together forming collective excitations, so-called excitons, plays a key role in for example the extraordinary fast energy transfer involved in the first steps of photosynthesis. The characterization of excitonic states in conj
Rheumatoid arthritis (RA) is probably the most common source of treatable disability in the Western world. There are several disease-modifying antirheumatic drugs (DMARDs), which have proven to be of therapeutic efficacy in RA, but the lack of a potent, reliable treatment for early RA is a major problem in modern medicine. An obvious line of approach in the quest for better antirheumatic drugs is
Volatile agents are economically and ecologically acceptable only when administered via low-flow systems. However, sevoflurane degrades during low-flow anaesthesia to compound A, and a high carbon dioxide absorber temperature increases this degradation. This thesis suggests that there is a correlation between apparatus dead-space volume and absorber temperature during low- and minimal-flow sevoflu
Lymphocytes are important mediators of adaptive immune responses. Naive T lymphocytes circulate in the blood and lymph between different secondary lymphoid organs in search for their specific antigen. Upon activation, lymphocytes change their expression of adhesion molecules and chemokine receptors and become able to enter non-lymphoid tissues where they take part in fighting infections. Selective
The enzyme magnesium chelatase inserts magnesium into protoporphyrin IX (Proto) to produce to magnesium protoporphyrin IX, the first unique intermediate of the chlorophyll biosynthetic pathway. Magnesium chelatase is composed of three distinct proteins termed I (molecular weight ~40 kDa), D (~70 kDa) and H (~140 kDa). Defining the individual properties and structure of the magnesium chelatase comp
Based on the discovery of a new amino acid transport system in Langerhans cells (LC), various aspects concerning the L-dopa uptake mechanism into human epidermal LC and the energy metabolism of epidermis have been examined and subsequently characterised. The system lacks any characteristics of other described amino acid transport systems in other cell types. The Falck/Hillarp histofluorescence met
This thesis is a description of how knowledge of atomic physics can be used in a stellar spectrum analysis. Stellar investigations are spectroscopically performed based on wavelengths, intensities and spectral line structure. Properties such as isotopic shifts, hyperfine structure, Zeeman effect, line blending and spectral line broadening are investigated in stellar spectra to improve results of a
In higher plants photosynthesis takes place in the chloroplast. This work focuses on two different processes that effects photosynthesis. Firstly, we studied the events occurring prior to the phosphorylation of LHCII. Secondly, we also studied two novel proteases, with the potential to degrade LHCII. In oxygenic photosynthesis two different photosystems partake in the gathering of light, PSI and
