Sökresultat

PURPOSE OF REVIEW: The extracellular matrix (ECM) is critical for all aspects of vascular pathobiology. In vascular disease the balance of its structural components is shifted. In atherosclerotic plaques there is in fact a dynamic battle between stabilizing and proinflammatory responses. This review explores the most recent strides that have been made to detail the active role of the ECM - and its

Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of

Background: Adult-onset diabetes comprises subgroups differing in pathophysiology, clinical presentation, and risk of comorbidities. We investigated early phenotypic differences between individuals who later developed diabetes, stratified by subgroup at diabetes diagnosis. Methods: We conducted a pooled analysis of nine prospective European cohorts with 3309 individuals developing incident diabete

Aim: To value the importance of research on avian migration for the development and current status of Spanish ornithology. Results and Conclusions: Avian migration has always been an outstanding field in ornithology. This assertion is particularly true in Spain, as we illustrate here by discussing the contribution of migration research to both the scientific and historical development of Spanish o

OBJECTIVES: To determine whether a long-term treatment with beta-blockers influences the inflammatory activity in carotid artery disease by reducing the carotid plaque levels of lipoprotein-associated phospholipase A2 (Lp-PLA2), its enzymatic products lysophosphatidylcholine (lysoPCs), and of soluble urokinase plasminogen activator receptor (suPAR). MATERIALS AND METHODS: One hundred and thirty-fo

This paper is based on the keynote talk that I gave on the EAHIL+ICAHIS+ICLC 2015 Workshop in Edinburgh. A starting point for the talk was the theme for the Workshop: “Research-minded: supporting, understanding, conducting research”. Some features of qualitative research are presented and a number of methods are mentioned before zooming in on interviewing, discussing some aspects of that method wiThis paper is based on the keynote talk that I gave on the EAHIL+ICAHIS+ICLC 2015 Workshop in Edinburgh. A starting point for the talk was the theme for the Workshop: “Research-minded: supporting, understanding, conducting research”. Some features of qualitative research are presented and a number of methodsare mentioned before zooming in on interviewing, discussing some aspects of that method wit

To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association sign

The tourism sector declared a climate emergency in 2020. It is against this background that this Curated Collection on Climate Change and Tourism is launched. A bibliometric analysis of 1290 articles reviews the 35-year development of climate change and tourism scholarship, including major research themes, key knowledge gaps, and our capacity to deliver the enormous knowledge requirements for an e

The sharing economy emerged in the last decade as an innovative business model in response to economic fallout, societal distress, and surging awareness over the devastating effects of the climate crisis. It pledges to repudiate mass consumption in favour of a democratization of access to common resources. This thesis seeks to dissect how the Japanese government has employed the sharing economy––a

The leading cause of morbidity and mortality worldwide is atherosclerotic cardiovascular disease, most commonly caused by rupture of a high-risk plaque and subsequent thrombosis resulting in stroke, myocardial infarction or sudden death depending on the affected arterial territory. Accurate, non-invasive methods to identify such lesions known as vulnerable or high-risk plaques are currently sub-op

Background and aims: Histopathology is the gold standard for analysis of atherosclerotic plaques but has drawbacks due to the destructive nature of the method. Ex vivo MRI is a non-destructive method to image whole plaques. Our aim was to use quantitative high field ex vivo MRI to classify plaque components, with histology as gold standard.Methods: Surgically resected carotid plaques from 12 patie

Stem cell-based approaches hold much promise as potential novel treatments to restore function after stroke. Studies in animal models have shown that stem cell transplantation can improve function by replacing neurons or by trophic actions, modulation of inflammation, promotion of angiogenesis, remyelination and axonal plasticity, and neuroprotection. Endogenous neural stem cells are also potentia

High plasma levels of VLDL are associated with increased risk for atherosclerosis. Here we show that VLDL (75 to 150 microg/mL) activates nuclear factor-kappaB (NF-kappaB), a transcription factor known to play a key role in regulation of inflammation. Oxidation of VLDL reduced its capacity to activate NF-kappaB in vitro, whereas free fatty acids such as linoleic and oleic acid activated NF-kappaB

The chapter presents a new perspective that concerns reception of multimodality and emphasizes how multimodal messages are perceived by the users. This perspective is described in relation to three main production-oriented perspectives: social semiotic multimodal analysis, a systemic functional approach and multimodal interactional analysis. It is argued that eye tracking measurements, in combinat

Medverkande företag / CompaniesNSR - Nordvästra Skånes Renhållnings ABSYSAV - Sydskånes avfallsaktiebolag Relaterade projekt / Related projectsFrom waste management to waste prevention - Closing implementation gaps through sustainable action netsGoverning in Action Nets: Swedish Municipalities and their Waste Responsibilities Andra avfallsprojekt / Other waste projectsBiogas Research Center, Linkö

https://www.ses.lu.se/organisering-av-kritiska-infrastrukturtjanster-0/lankar-links - 2026-10-04

Neuropathological changes in Parkinson's disease progress slowly and spread according to a characteristic pattern. Recent papers have shed light on this progression of pathology by examining the fate of neurons grafted into the brains of patients with Parkinson's disease. Two of these studies demonstrate that grafted healthy neurons can gradually develop the same pathology as host neurons in the d