Filtyp
CRISPRideas TEMA 2019-2020 Utvecklingen av nya genredigeringstekniker som CRISPR-Cas9 har skapat en revolution inom biologisk och medicinsk forskning. De innebär möjligheter att göra precisa och riktade förändringar i arvsmassan på alla slags organismer, från mikroorganismer till människor. Inom växtförädlingen finns förhoppningar att kunna utveckla nya grödor som är bättre anpassade till ett fram
https://www.pi.lu.se/sites/pi.lu.se/files/2021-01/CRISPR%20SVE.pdf - 2026-09-20
Species and Alien Species ASG 2019-2020 Genom den senaste tidens uppmärksamhet på "invasiva främmande arter" befinner sig växter nu i centrum för en ny samhällsdiskussion. I linje med denna utveckling publicerades den första svenska listan över främmande invasiva arter i år. Denna ASG ”Species and Alien Species” syftar till att sätta listan om invasiva främmande arter i ett samhälleligt sammanhang
https://www.pi.lu.se/sites/pi.lu.se/files/2021-01/alien_species_sve.pdf - 2026-09-20
Sweden has a long history of maintaining population-based registries and biobanks. This has resulted in large sample collections with long follow-up and large numbers of prospectively occurring disease endpoints providing an extensive resource for genetic research. However, the largest biobanks contain sample materials that have previously been considered suboptimal for genetic research. We have
Material decomposition in computed tomography is a method for differentiation and quantification of materials in a sample and it utilizes the energy dependence of the linear attenuation coefficient. In this study, a post-image reconstruction material decomposition method is constructed for a low-energy micro-CT setup using a photon counting x-ray detector. The low photon energy range (4–11 keV) al
SLA research is characterised by a striking homogeneity in the linguistic, social and geographical data we draw on. Such empirical homogeneity is a potential threat to the validity and scope of our claims and theories. This paper focuses on a particular gap in our knowledge, namely the SLA of sign languages. It outlines an argument for why the SLA of sign matters to general SLA research in terms o
The article explores the degree to which memory studies has become established as an academic field. Although we acknowledge that there are drawbacks to formal institutionalization, we contend that it is useful to think strategically about the future of memory studies. We argue that three key developments must take place in order for a field to become institutionalized. First, individual scholars
Background: Although teamwork and interprofessional collaboration arecritical to patient safety, nursing, medical, and allied health graduates oftenfeel ill-prepared to confidently communicate and collaborate with other teammembers. While interprofessional education (IPE) has been advocated as a wayof addressing this issue, there are multiple barriers to its systematic and sustained integration in
Regression testing is a means to assure that a change in the software, or its execution environment, does not introduce new defects. It involves the expensive undertaking of rerunning test cases. Several techniques have been proposed to reduce the number of test cases to execute in regression testing, however, there is no research on how to assess industrial relevance and applicability of such tec
Global warming is driving environmental change in the Arctic. However, our current understanding of this change varies strongly among different environmental disciplines and is limited by the number and distribution of field sampling locations. Here, we use a quantitative framework based on multivariate statistical modeling to present the current state of sampling across environmental disciplines
Transition metals such as copper and zinc are essential elements required for the survival of most organisms, from bacteria to humans. Yet, elevated levels of these elements are highly toxic. The Copper TRansporter protein family (CTRs) represents the only identified copper uptake proteins in eukaryotes and hence serves as key components for the maintenance of appropriate levels of the metal. More
Aims/hypothesis: Given the importance of glucagon in the development of type 2 diabetes and as a potential therapeutic agent, the aim of this study was to characterise glucagon kinetics in mice and its regulation by the nutritional state. Methods: Anaesthetised C57BL/6 mice fed normal or high-fat diets, or fasted, were injected intravenously with glucagon (0.1, 0.3, 1.0, 10.0 or 20 μg/kg); blood s
Smoking is the main risk factor for COPD (chronic obstructive pulmonary disease) but genetic factors are of importance, since only a subset of smokers develops the disease. Sex differences have been suggested both in disease prevalence and response to environmental exposures. Furthermore, it has been shown that acquisition of 'addiction' to smoking is partly genetically mediated. Disease cases and
Height is a classic complex trait with common variants in a growing list of genes known to contribute to the phenotype. Using a genecentric genotyping array targeted toward cardiovascular-related loci, comprising 49,320 SNPs across approximately 2000 loci, we evaluated the association of common and uncommon SNPs with adult height in 114,223 individuals from 47 studies and six ethnicities. A total
Malfunction and amyloid formation of the Islet Amyloid Polypeptide (IAPP) are factors contributing to Type 2 diabetes. Unravelling the mechanism of IAPP aggregate formation may forward our understanding of this process and its effect on pancreatic β-islet cell. Such mechanistic studies require access to sequence homogeneous and highly pure IAPP. Here we present a new facile protocol for the produc
