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The amyloid β-protein (Aβ) is believed to play a central role in Alzheimer’s disease (AD) pathogenesis and there is great interest in understanding the process of Aβ aggregation, its underlying mechanism and the species generated during aggregation and their biological activity. Although Aβ has been studied for more than 30 years, analysis of its aggregation has been hampered by structural and che
The last decade has witnessed a revolution in genetic technology, where genome-wide analyses, covering the majority of genetic variation, were thought to explain disease-causing mechanisms in common metabolic disorders. However, these genetic data only explain a modest proportion of the estimated heritability of type 2 diabetes and obesity and hence suggest a potential role for epigenetic variatio
This study aims to examine the topic of innovation in China. The need for innovative development is of importance for the nation to keep the rapid development. A few evaluations of both Chinas indigenous innovation policy and the opportunities for the citizens to develop innovation has criticized the lack of creativity in human resources and the examination based education system to be harmful for
Objective: To identify possible suicide risk factors in a clinical sample and suicide risk in a general population, with primary focus on mental disorders, signs, symptoms and comorbidity. Methods: In the first two studies, subjects who had been admitted to a specialised psychiatric ward after a suicide attempt were investigated. Fifteen suicide completers were compared to matched survivors in te
Recent years has seen increasing interest in the concept of affordances in music performance research. Hereby, the agency of musical instruments is understood as defined by the perceived opportunities for action emerging through the sensorimotor relationship (i.e. the continuous interaction between musician and instrument). As such, it is an analytical perspective that highlights material and embo
As the field of neural organoids and assembloids expands, there is an emergent need for guidance and advice on designing, conducting and reporting experiments to increase the reproducibility and utility of these models. In this Perspective, we present a framework for the experimental process that encompasses ensuring the quality and integrity of human pluripotent stem cells, characterizing and man
Popular Abstract in Swedish Föräldrars involvering i skolan har under de senaste decennierna betonats allt mer i skoldebatten. Länge betraktades skolutbildning som enbart ett samhälleligt ansvar, vilket ofta medförde ett markerat avståndstagande från familjen och föräldrarna. Likt andra samhälleliga servicefunktioner har emellertid också skolan i sitt förhållande till sina användare undergått en fOver the last two decades, educational reforms have stimulated an enormous growth in innovative school thinking, effecting both independent schools and mainstream education. Parents and interest groups, previously excluded from general pedagogic practice and planning, are now faced with new opportunities and responsibilities. Parents “invest” in these newly won options in very different ways. Fail
The anthropological sciences have long been interested in how hunter-gatherers perceive and interact with their spatial environment. The spatially flexible and dynamic modes of subsistence and residence typical of many hunter-gatherer communities have been considered to be key factors in the social organisation and ideological framing of such communities. However, close attention to spatial repres
This study explores how insights from critical disability studies and critical disaster studies can inform more inclusive approaches to disaster risk reduction (DRR). Although disability-inclusive DRR policies call for the involvement of disabled people, structural ableism and unequal power relations can limit participation. While critical disaster studies increasingly considers marginalized popul
Denna masteruppsats har som mål att utvärdera på vilket sätt nivån av presence inom virtuell verklighet (VR) påverkar användares prestation i en miljö när de ut- för uppgifter. Den utvärderar även hur mycket ansträngning som bör läggas för att göra VR-miljöer mer realistiska i forskningssammanhang. Denna studie genom- fördes i två primära delar; först en utvecklingsfas där en gedigen informationss
The rabbit is a common laboratory animal used for research in dental implants, mainly as a screening model. It has many advantages compared to other laboratory animals. Availability, handling, cost-effectiveness, and early skeletal maturity are a few. For the model’s validity, there need to be similarities to the human. Although there are similarities between human and rabbit anatomy, there are al
This chapter gives an introduction to the European Research Infrastructure Consortium (ERIC) – a European Union (EU) policy tool introduced in 2009 with the purpose to set up and operate collaborative Research Infrastructures by granting them a legal personality and qualities of an international organization. The shared responsibility between the member states and the EU in the research and innova
